Extracellular ATP
Allosteric modulation of GABAA receptors by extracellular ATP
... of ATP on mIPSCs. ATP at a concentration of 2 mM, but not 100 μ M, potentiated ...lines) ATP application illustrating a specific increase in the mIPSC amplitude without alteration of its ...of ...
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Extracellular ATP Is Cytotoxic to Mononuclear Phagocytes but Does Not Induce Killing of Intracellular Mycobacterium avium subsp. paratuberculosis
... ruminants. ATP has been reported to induce cell death of macrophages and killing of Mycobacterium species in human and murine ...of ATP on the viability of ...mM ATP to ...)-O-(4-benzoylbenzoyl) ...
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Evidence for Extracellular ATP as a Stress Signal in a Single-Celled Organism
... ume recovery, also block NO production during cell swelling. Moreover, NO donation can rescue cell volume recovery in the presence of apyrase or Gd 3⫹ . These data strongly suggest that NO production lies downstream of ...
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Extracellular ATP reduces HIV 1 transfer from immature dendritic cells to CD4+T lymphocytes
... of ATP on DC biology, ...Because ATP is released from activated T lymphocytes, activated platelets, or necrotic cells, its presence is a hallmark of inflamed ...of ATP ranging from 5 to 10 mM, any ...
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Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation
... degraded extracellular ATP to <1% of control levels within 2 minutes; continuous exposure to apyrase maintained this inhibition for up to 14 ...endogenous ATP in stimulating cell ...the ATP ...
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Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites
... 1 Extracellular ATP triggers intracellular protease activity in ...of ATP (200 μ M) and the control in isolated (saponin treated) free mixed blood stages of ...hydrolysis. ATP (200 μ M) ...
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Potential Role of Extracellular ATP Released by Bacteria in Bladder Infection and Contractility
... of ATP from erythrocytes and other cells but do not directly involve GABA, which was shown here to mitigate the calcium influx and myofibroblast contraction ...of ATP, such as by use of the enzyme apyrase, ...
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The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading
... Wang, N., Rumney, R.M.H., Yang, L. et al. (4 more authors) (2013) The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading. Journal of Bone and Mineral ...
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Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium
... the extracellular compart- ment in response to tissue damage or inflammation, extracellular ATP has been shown to act as a potent inducer of inflammation [4, ...Although ATP is known to be ...
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Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control
... Cell death plays a key role in regulating the number of neurons in the brain from its earliest stages of development. Death has been described among proliferating neuroblasts, early postmitotic cells and in many ...
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Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation
... that extracellular ATP alone induced a transient contractile response in airways is in agreement with previ- ous studies that have evidenced such a response profile in mouse IPB [8] and guinea-pig trachea ...
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The inhibitory effects of extracellular ATP on the growth of nasopharyngeal carcinoma cells via P2Y2 receptor and osteopontin
... by extracellular nucleotides, to the processes of several diseases ...[1]. Extracellular nucleo- tides, particularly ATP, are important transmitters that mediate various biological effects via ...
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Effects of Extracellular ATP on Bovine Lung Endothelial and Epithelial Cell Monolayer Morphologies, Apoptoses, and Permeabilities
... of extracellular ATP on bovine lung endo- thelial and epithelial ...of ATP ( ⱖ 1 mM) induced rapid and reversible changes in the permeability of the cell monolayers that did not involve increased ...
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Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
... with increased expression of different purinergic recep- tors. Therefore, we propose that such change in P2R levels observed in both APAP-treated cells and in liver biopsies from acute hepatitis patients may be a ...
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GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3
... Extracellular ATP is a ubiquitous molecule in the extracellular matrix and is involved in diverse cellular responses by binding to P2 receptors ...[21]. Extracellular ATP was first ...
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The P2X7 receptor is an important regulator of extracellular ATP levels
... released ATP at all times, although levels were highest at the beginning of the culture period (day ...in extracellular ATP levels was accompanied by a large decrease in cell viability and is ...
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Extracellular ATP selectively modulates a high voltage activated calcium conductance in salivary gland cells of the leech Haementeria ghilianii
... Extracellular ATP appears to have a widespread role as a neurotransmitter or neuromodulator in mammals (Gordon, 1986; Burnstock, 1990), but little is known about any similar functions in ...an ...
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Inhibition of voltage dependent Ca2+influx by extracellular ATP in salivary cells of the leech Haementeria ghilianii
... figure). ATP (1 m mol l 21 ) reduced the number of action potentials to two without affecting the depolarization ...of ATP) elicited four action potentials, and in the presence of adenosine (10 m mol l 21 ) ...
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Extracellular ATP can activate autonomic signal transduction pathways in cultured equine sweat gland epithelial cells
... with ATP and this was blocked by staurosporine, an inhibitor of protein kinase C, and augmented by a phorbol ester which acts as an exogenous activator of this ...with ATP. ATP and related compounds ...
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The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes
... ATP release in cartilage is modulated by mechanical stimuli such as tissue compression and by changes in os- motic pressure. These stimuli are linked by similar ef- fects on membrane tension, and often share ...
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