Extracellular calcium-sensing receptor
A role for the extracellular calcium sensing receptor in cell cell communication in pancreatic islets of Langerhans
... CaR activation has been associated with increased proliferation in a variety of cell types, including fibroblasts [8], astrocytoma cells [30], and osteoblasts [31], and our results are consistent with a role for the CaR ...
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The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells
... Intracellular calcium, a secondary messenger, plays a key role in various physiological ...that extracellular calcium can act as a first messenger through the calcium-sensing ...
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Extracellular calcium sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
... was significantly lower (p<0.01) than in control siRNA-A transfected cells. Similarly, we observed a dramatic reduction in ERK1,2 activation in cells treated with either PD98059 or U73122 and neomycin, when compared ...
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Homology Modeling of the Calcium Sensing Receptor Extracellular Domain
... The extracellular calcium-sensing receptor (CaR) on the parathyroid cell surface negatively regulates secretion of parathyroid hormone ...this receptor was approved by FDA in 2004 for ...
8
Calcium sensing receptor activation increases cell cell adhesion and ß cell function
... The extracellular calcium sensing receptor (CaR) plays a central role in maintaining systemic Ca 2+ -homeostasis by regulating the secretion of parathyroid hormone and urinary calcium ...
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Expression of the calcium sensing receptor on human antral gastrin cells in culture
... the extracellular calcium-sensing receptor on human antral gastrin cells was ...cell calcium-sensing ...the extracellular region of the receptor immunostained all ...
7
Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption
... decreased net Ca 2+ absorption across intestinal preparations acutely. Conversely, Ca 2+ absorption increased with decreasing extracellular Ca 2+ concentration. These responses were absent in mice expressing a ...
14
Diseases associated with calcium-sensing receptor
... 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium- binding ...
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SINGLE NUCLEOTIDE POLYMORPHISMS OF CALCIUM SENSING RECEPTOR ENCODING GENE ASSOCIATED WITH CALCIUM KIDNEY STONE DISEASE IN BABYLON PROVINCE
... urine calcium levels, calcium supplements, certain foods, obesity, hyperparathyroidism, gout, some medications, and not drinking enough ...The calcium-sensing receptor (CASR) is a ...
5
Apical extracellular calcium/polyvalent cation sensing receptor regulates vasopressin elicited water permeability in rat kidney inner medullary collecting duct
... and calcium homeostasis in hu- mans that contribute to the pathogenesis of renal stone forma- ...minal calcium have also been reported to alter potassium transport ...
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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium sensing receptor deficient mice
... The calcium-sensing receptor (CaR; CASR – Mouse Genome Informatics) is a plasma membrane G-protein-coupled receptor that is activated by extracellular ...systemic calcium ...
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Successful treatment of neonatal severe hyperparathyroidism with cinacalcet in two patients
... The calcium-sensing receptor (CASR) is a 1078 amino acid cell surface protein with a large extracellular domain that tightly regulates calcium homeostasis ...increasing ...
7
Protein-induced satiation and the calcium-sensing receptor
... in both rats and mice, and a chronic reduction in food intake and body weight in diet-induced obese mice. This affect was also seen when L-Phe was given via the ileum. Pharmaco- logical blockade of the CaSR attenuated ...
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PTH independent regulation of blood calcium concentration by the calcium sensing receptor
... that extracellular, luminal Ca, or polycations are able to decrease the permeability of the collecting duct epithelium to water; ...high extracellular Ca concentration is able to induce poly- uria has ...
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Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
... the calcium sensing receptor ...the extracellular domain of the Ca-SR, whereas none of the AH patients sera reacted to the intracellular ...
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Quorum Sensing Extracellular Death Peptides Enhance the Endoribonucleolytic Activities of Mycobacterium tuberculosis MazF Toxins
... removing the anti-Shine-Dalgarno (aSD) sequence required for the initiation of the translation of canonical mRNAs (12). Moreover, the term “mRNA interferase” was also challenged by Woychik and colleagues (13, 14), who ...
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The calcium sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
... spine. Since multiple hypotheses were tested in the course of the various studies described in this paper, we acknowledge the possibility that this result may repre- sent a “false positive,” particularly given the P ...
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A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations
... in calcium homeostasis and is widely expressed in tissues including kidney, parathyroid glands and bone cells which are involved in calcium metabolism ...
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Biological Function of Calcium-Sensing Receptor (CAS) and Its Coupling Calcium Signaling in Plants
... plant. However, the underlying mechanism regulating this process is lacking. Furthermore, recent evidence suggests that CAS may perform additional roles in the plant. Here, we provide an update covering the multiple ...
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Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae
... well-studied extracellular glucose sensors Snf3 and Rgt2 exhibited a novel role in cellular ATP homeostasis partially through the major plasma membrane ATPase ...of extracellular glucose sensors (Snf3 and ...
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