extracellular domain
Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain
... TF extracellular domain mutant to rescue mTF null embryos may be due to a lack of hTF expression at ...TF extracellular domain mutant, and both failed to rescue mTF null ...the ...
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Targeting Adenoviral Vectors by Using the Extracellular Domain of the Coxsackie-Adenovirus Receptor: Improved Potency via Trimerization
... the extracellular domain of CAR fused to peptide-targeting ...receptor-binding domain of apolipoprotein E ...trimerization domain was introduced, and trimerization was verified by ...
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The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread
... of extracellular virions (10) and (ii) gE/gI accumulates specifically at epithelial cell junctions and is absent from those lateral surfaces not in contact with another cell ...the extracellular ...
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Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human α4β2 Nicotinic Acetylcholine Receptor
... the extracellular domain of the human α4β2 nAChR (hereafter referred to as human α4β2 nAChR) using the X-ray crystal structure of Ct-AChBP that was deter- mined at a high resolution ...
60
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian pPeptide transport
... this extracellular domain (ECD) is unknown; however, its presence would suggest the requirement for additional functionality to assist peptide uptake in ...annotated extracellular ‘‘loop’’ in early ...
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<p>Identification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab</p>
... Recombinant fusion proteins for enzyme-linked immuno- sorbent assay (ELISA) and surface plasmon resonance (SPR) analysis were produced in HEK293F cells. Brie fl y, DNA encoding the human WT (HER2-ECD-WT) or S310F-mutant ...
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Construction and Expression of Transmembrane and Secretory Recombinant Human CD4 Extracellular Domain in HEK293F Cell
... It needs to solve the problem of immunogenic- ity when making CD4 ECD as the tumor protein vaccine. CD4 ECD has weak immunogenicity, which must be used in combination with immune adjuvant, so to be uptaken and processed ...
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Effect of compounds on the purification and antibody preparation of the extracellular domain fragment of the receptor CD163
... an extracellular protein, consists of a signal peptide, 9 scavenger receptor cysteine-rich (SRCR) tan- dem repeats numbered 1-9, a transmembrane (TM) region, and an intracellular cytoplasmic tail (Figure ...the ...
6
Nephritogenic mAb 5 1 6 is directed at the extracellular domain of rat nephrin
... the extracellular domain of nephrin, thereby documenting the importance of the slit- diaphragm and its component, nephrin, in the regulation of glomerular ...
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The non-small cell lung cancer EGFR extracellular domain mutation, M277E, is oncogenic and drug-sensitive
... kinase domain, the human epidermal growth factor receptor 2 kinase domain, as well as the KRAS, BRAF, ALK, ROS1 and RET ...EGFR extracellular domain ...
9
Enhanced immuno detection of shed extracellular domain of HER 2/neu
... shed extracellular domain (sECD-HER 2/neu) is indicative of the potential presence and as- sociated progression of this ...“shed extracellular domains”, in general, and the role of these “proteolytic ...
5
Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation
... small extracellular domain and one large extracellular domain (EC2) which has 2, 3 or 4 pairs of cysteine residues, with one pair in a highly conserved ‘CCG’ ...
17
Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89 Zr-imgatuzumab
... HER2 extracellular domain (ECD) and trastuzumab are known to form complexes, which are swiftly cleared by the liver ...EGFR extracellular domain (sEGFR) in patients and healthy volunteers ...
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The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation.
... predicted extracellular domain of the BZLF2 protein was constructed ...the extracellular domain of the BZLF2 protein was positioned carboxy proximal to optimize the po- tential for binding to ...
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Functional Analysis of Vaccinia Virus B5R Protein: Essential Role in Virus Envelopment Is Independent of a Large Portion of the Extracellular Domain
... In conclusion, this work provides evidence that the majority of the extracellular domain is required for induction of actin bundles, while it is dispensable for normal envelopment and egress of enveloped ...
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Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein.
... 5 0022-538X/93/052747-09$02.00/0 Copyright X 1993, American Society for Microbiology Effects of Amino Acid Changes in the Extracellular Domain of the Human Immunodeficiency Virus Type 1 [r] ...
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Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function
... protein extracellular domain (ECD) [33,34] has been used to build a model of the HRSV F pro- tein ECD ...the extracellular domain of the F protein of human parainfluenza virus 3 (hPIV3) has ...
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Entry of Amphotropic Murine Leukemia Virus Is Influenced by Residues in the Putative Second Extracellular Domain of Its Receptor, Pit2
... five extracellular domains, A for those derived from the A-MuLV receptor (Pit2) and G for those derived from the GALV receptor ...second extracellular domain of Pit1 with that of Pit2 between the ...
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Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
... Acquired hypoparathyroidism (AH) has been considered to result from an autoimmune process but the self-antigens have not been identified. We studied 25 patients with AH, of which 17 had type I autoimmune polyglandular ...
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Homology Modeling of the Calcium Sensing Receptor Extracellular Domain
... The human homologue of the CaR is a G protein-coupled receptor (GPCR) consisting of 1078 amino acid residues. The first 612 amino acids are included in a large extracellular domain (ECD), which is a feature ...
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