Extracellular HMGB1
Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer
... Extracellular HMGB1 acts through binding to several cell surface receptors, including RAGE [8, ...of HMGB1 to RAGE is thought to stimulate proliferation and differentiation of cancer cells ...
9
Mechanistic regulation of HMGB1 function in drug-induced liver injury
... reduced HMGB1 (C23, C45 and C106 as thiols) also plays a key role in inflammatory signalling by acting as a chemoattractant for immune cells through interaction with CXCL12 and signalling via CXCR4 (Venereau et ...
228
Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β
... Secreted HMGB1 can reduce DENV replication in DCs, accompanied with the increased expression of IFN-α ...and extracellular HMGB1 play opposite roles in HCV ...propagation. Extracellular ...
17
Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype
... bind HMGB1, preventing its release during this form of programmed cell death ...secrete HMGB1, via a dedicated pathway, and thus produce a damage signal without associated cell death ...released, ...
9
Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain
... marked HMGB1 accumulation in CSF and serum after transient MCAO, and its aggravation of brain damage via autocrine and paracrine mechanisms [13, 14, ...whether HMGB1 induces NETosis in the ischemic brain, ...
14
Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
... by extracellular HMGB1 to mediate inflammation (reviewed by Andersson et ...addition, extracellular HMGB1 augments inflamma- tory responses by binding other pro-inflammatory me- diators ...
13
HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells
... the extracellular space upon the cell dam- age, it becomes an immune-inflammatory factor [11– ...enables HMGB1 export from nucleus to cytoplasm or the extracellular space, and acetylation of ...
11
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II induced arthritis
... nuclear HMGB1 sequestration coincided with beneficial therapy outcome sup- port this ...with extracellular HMGB1 ...the extracellular release of HMGB1 from activated macrophage-like ...
9
Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis
... of HMGB1 in pancreatic cancer are complicated and paradoxical depending on the intracellular or extracellular locations ...extracellularly. HMGB1 is actively secreted by inflammatory cells or ...
15
Original Article Expression of HMGB1/RAGE protein in renal carcinoma and its clinical significance
... human HMGB1 gene is located on chromo- some 13q12, and it encodes a protein with a molecular weight of approximately 30 ...kD. HMGB1 is widely distributed in the human body, including in the heart, liver, ...
7
Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... Measuring HMGB1 in whole-cell protein extracts showed ele- vated levels of HMGB1 protein in the spinal cord after the induction of nerve ligation (75), diabetic neuropathy (80) and bone cancer (79) (Table ...
10
Bench to bedside review: High mobility group box 1 and critical illness
... identified HMGB1 as a cytokine-like mediator of lipopolysaccharide (LPS)-induced mortality in ...that HMGB1 is also a mediator of lethality in mice rendered septic by the induction of polymicrobial ...
8
High Mobility Group Protein Bl (HMGB1) in Asthma: Comparison of Patients with Chronic Obstructive Pulmonary Disease and Healthy Controls
... with HMGB1 levels in the sputum from COPD ...release HMGB1 upon activation with granulocyte-macrophage colony- stimulating factor (GM-CSF), tumor necrosis factor (TNF)-α or interferon (IFN)-γ (26), we found ...
9
Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... which HMGB1 and IL-1β directly ...that HMGB1 is able to interact with a diverse range of endogenous and exogenous molecules to mediate a range of biological activities (Dintilhac and Bernués 2002; Ivanov et ...
191
High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study
... To our knowledge, blood lactate monitoring is widely used as a primary biomarker of tissue hypoxia in the as- sessment of the traumatized patient and the critically ill patient admitted to Emergency Department (ED). Sev- ...
7
Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)
... anti-human HMGB1 antibodies were purchased from Abcam (Cat #ab18256, Cambridge, ...UK). HMGB1 enzyme-linked immunosorbent assay (ELISA) kit was purchased from Shino-Test Corporation (Tokyo, ...
10
HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors
... circulating HMGB1 increased after d 7 and remained elevated for at least 28 d (Figure 1I), a pattern consistent with previous observations that HMGB1 is a lateoccurring mediator of ...for HMGB1 in ...
8
PubMedCentral-PMC5235959.pdf
... if extracellular levels of HMGB1 increased with longer RBC storage, HMGB1 levels were measured in supernatants of stored RBC over ...mean HMGB1 level was determined to be ...of HMGB1 ...
20
HMGB1 is negatively correlated with the development of endometrial carcinoma and prevents cancer cell invasion and metastasis by inhibiting the process of epithelial-to-mesenchymal transition
... of HMGB1 protein was detected in normal endometrial stroma and the endo- metrial glandular epithelial cell nucleus (Figure 1A and ...of HMGB1 was very ...of HMGB1 was detected at very low levels in ...
14
Original Article High-mobility group box 1-induced epithelial-mesenchymal transition of ovarian cancer through Smad3/Snail/NF-κB pathways
... 1999. HMGB1 dyregulation is associated with a large range of cellular functions including pro- liferation, metastasis, and invasion resulting in progressive and uncontrolled tumor ...that HMGB1 is ...
10