Extracellular matrix degradation
Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels
... Recent studies in genetically altered mice have suggested an important role for multiple proteases in the development of emphysema. Mice deficient in MMP-9, MMP-12, or NE are resistant to the development of emphysema or ...
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Imbalance in extracellular matrix degradation in urethral stricture
... function and also in the remodeling phase of the extracellular matrix. TIMPs also have antiapoptotic effects. TIMP1 serves as a potent inhibitor of MMP1 that organizes regulation of the extracellular ...
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Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1 induced extracellular matrix degradation
... continued to express transgenic protein. Chondrocytes transduced with Ad.RSV hIL-1ra and seeded onto the surface of osteoarthritic cartilage secreted high levels of biologically active IL-1 receptor antagonist. The ...
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Silencing of microRNA 101 prevents IL 1β induced extracellular matrix degradation in chondrocytes
... Collagen type II and aggrecan are chondrocyte ECM genes that are down-regulated during chondrocyte ECM degradation [12,30,31]. In the present study, IL-1 b inhibited the expression of collagen type II and aggrecan ...
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A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor
... encompasses degradation of 28S ribosomal subunit RNA and associated P proteins and fragmentation of nuclear ...collagen matrix is degraded with the ac- cumulation of three-quarter length type I collagen ...
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A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation
... ECM degradation in fibroblasts (which otherwise lack invadopodia) and breast carcinoma cells [28, 29], while treatment with Src inhibitors or expression of kinase- inactive Src mutants, inhibits invadopodia ...
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Original Article LincRNA-SLC20A1 (SLC20A1) promotes extracellular matrix degradation in nucleus pulposus cells in human intervertebral disc degeneration by targeting the miR-31-5p/MMP3 axis
... In this study, we discovered a novel SLC20A1/ miR-31-5p/MMP pathway in ECM degradation in NP cells from patients with IDD. However, the role of SLC20A1 in cell growth, cell death, and inflammation remains to be ...
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Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
... ECM degradation and cell invasion ...that degradation of type IV collagen was predominantly pericellular and that a cell impermeant cathepsin B inhibitor reduced their degradation of type IV collagen ...
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Dramatic early event in chronic allograft nephropathy: increased but not decreased expression of MMP-9 gene
... that extracellular matrix degradation should be prerequisite for the migration of mononuclear cells and other cells in the tissue, and the ability of MMP-9 to degrade components of the ...
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An In-silico Approach to Explore the Possible Multifunctional Neuroprotective Efficacy of Violacein against Ischemic Stroke
... like degradation of extracellular matrix resulting in blood brain barrier disruption, intra cranial haemorrhage, activation of astroglial cells and hence death of ...diseases. Matrix ...
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Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention
... removing matrix barriers or initiating signaling path- ways that promote or support the angiogenic ...generate extracellular matrix degradation fragments, leading to signals required for cell ...
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Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
... maintaining extracellular matrix homeostatsis and the preventing cardiac fibrosis, TGF-beta, α-SMA and TIMP-2 were determined as mar- ker of ECM synthesis, while MMP-2 was assayed as an indicator of ECM ...
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The Extracellular Matrix of Staphylococcus aureus Biofilms Comprises Cytoplasmic Proteins That Associate with the Cell Surface in Response to Decreasing pH
... biofilm matrix, we observed that even a het- erologous protein, GFP, could associate in a pH-dependent man- ner with cells when grown under biofilm-inducing conditions but not when grown under planktonic ...
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Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression
... ECM degradation in OA ...mediated degradation of fibronectin in cartilage may contribute to OA progress ...the degradation of ECM, including collagens and aggrecans, and in modulating OA progression ...
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Elevated extracellular matrix production and degradation upon bone morphogenetic protein 2 (BMP 2) stimulation point toward a role for BMP 2 in cartilage repair and remodeling
... of extracellular matrix molecules and proteoglycan (PG) synthesis Effect of bone morphogenetic protein-2 (BMP-2) overexpression on mRNA levels of extracellular matrix molecules and ...
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Role of Matrixmetalloproteinases in Periodontal Disease - A Review
... the degradation of both non mineralized and mineralized tissues of the ...the matrix metalloproteinases which are released from different cell types present in the lesion including macrophages, leukocytes ...
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Clinical evaluation of a matrix metalloproteinase 12 cleaved fragment of titin as a cardiovascular serological biomarker
... During digestion of human tissue by an array of exogenous metalloproteinases, a large number of proteo- lyzed peptides have been identified using mass spec- trometry [36]. Among these, a titin specific fragment 12670’ ...
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Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis
... the extracellular matrix (ECM), which exists in the basement membrane, tumor stroma, and blood vessel walls, to emigrate from original tumor sites and invade adjacent tissues, and to eventually form ...
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Recent Advances in Tissue Engineering and Regenerative Medicine
... In order to overcome the shortcomings of the decellularized organs and bio inkjet printing organ new technology is emerged by merging both. In this method, organs are decellularized first [82,83] and then ECM from ...
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Aggrecanases and cartilage matrix degradation
... cartilage degradation during disease ...cartilage degradation during the progression of OA and RA, selec- tive inhibitors of each enzyme and the deletion of specific proteinase genes may be ...
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