Extracellular matrix remodeling factor
Cardiac remodeling in postischemic end stage human hearts: Involvement of extracellular matrix and angiogenesis related molecules
... Background: Extracellular matrix (ECM) partici- pates in heart growth and influences cardiac stem-cell differentiation and ...growth factor (VEGF)-A and VEGF ...
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Fibroblast growth factor 2 regulates human cardiac myofibroblast mediated extracellular matrix remodeling
... However, human 3D cell culture models have a number of distinct advantages over traditional cell culture experiments that may allow for improved translation to the human con- dition. First, we used cardiac myofibroblasts ...
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Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
... Given the multiplicity of MMP substrates, TIMPs should be viewed as molecules that mediate both ECM-dependent and ECM-independent events. TIMP-1 and TIMP-2 have been shown to stimulate growth of cells in culture, includ- ...
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MicroRNAs and Their Role in Bone Remodeling and Pathogenesis
... calcified matrix and are responsive to mechanical stresses (Bonewald et ...multiple extracellular signalling molecules, including macrophage colony-stimulating factor (MCSF), receptor activator for ...
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Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling
... Fgf10 also cooperates with the homeobox transcription factor Pax6, which is expressed in LG epithelium (Makarenkova et al., 2000). Pax6 is one of the earliest factors required for LG development, as shown by the ...
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Consequences of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Hepatic Stellate Cell Activation and Extracellular Matrix Remodeling During Chronic Liver Injury
... response to injury and unresolved inflammation (Friedman, 2000). Liver fibrosis is mediated by hepatic stellate cells (HSCs), which are non-parenchymal cells that normally function in vitamin A storage. Upon injury, HSCs ...
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Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction
... Other considerations for experimental design are sam- ple collection and storage conditions and potential solu- bility issues. With many clinical cohorts, samples were collected before we understood the importance of ...
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Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor κB ligand
... nuclear factor B ligand, also known as TRANCE, TNFSF11, OPGL, and ODF) is a member of the tumor necrosis factor family of signal- ing molecules, which functions in promoting osteoclast ...of ...
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Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans
... growth factor (EGF)–Ras– extracellular signal regulated kinase pathway; however, our genetic analyses suggested that LPR-1 and EGF act in parallel, and that LPR-1 protects duct lumen integrity through an ...
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Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells
... infarct matrix at 1 week did not negatively influence the expression of either transcription factor, the increased stiffness charac- teristic of the infarct significantly abrogated the differenti- ation ...
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Elevated extracellular matrix production and degradation upon bone morphogenetic protein 2 (BMP 2) stimulation point toward a role for BMP 2 in cartilage repair and remodeling
... growth factor-beta (TGF-β) superfamily, consist- ing of TGF-βs, growth differentiation factors, BMPs, activins, inhibins, and glial cell line-derived neurotrophic factor ...
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Expression of CD147 and matrix metalloproteinase 11 in colorectal cancer and their relationship to clinicopathological features
... the extracellular matrix (ECM) and some other ...cellular matrix component, instead, it catalyzes the deg- radation of serine protease inhibitors, a 1-antitrypsin and insulin-like growth ...
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Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma
... Obesity is a rising issue in the modern world that does not only threaten industrial countries but has developed to a worldwide problem. Obesity leads to several comorbidities and can increase the mortality of many acute ...
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The extracellular matrix in myocardial injury, repair, and remodeling
... Although each matricellular protein has a unique function- al profile, several unifying themes have emerged regarding their actions in the infarcted heart. First, the strikingly selective local- ization of prototypical ...
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The Extracellular Matrix of Staphylococcus aureus Biofilms Comprises Cytoplasmic Proteins That Associate with the Cell Surface in Response to Decreasing pH
... the matrix, elimination of just one such protein might have little effect on matrix ...for extracellular DNA (eDNA), which, along with protein, is required for biofilm ...
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Disorders of lung matrix remodeling
... of chronic fibrotic disorders (Table 1) have a persistent alveolitis (12, 13). This was found to be true whether or not any evidence of edema or inflammation was detectable on the plain radiograph, leading to the par- ...
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Clinical evaluation of a matrix metalloproteinase 12 cleaved fragment of titin as a cardiovascular serological biomarker
... Extracellular matrix (ECM) components are degraded by a number of different proteases including matrix metalloproteinases ...ECM remodeling in a number of different pathologies and can be ...
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Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... bers. All contain a conserved 120 amino acid core re- gion and act extracellularly through four tyrosine ki- nase FGF receptors (FGFRs 1–4) with various affinities (93). The extracellular region consists of two or ...
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Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study
... ECM: Extracellular matrix; EGFR: Epidermal growth factor receptor; FSH: Follicle-stimulating hormone; H&E: Hematoxylin and eosin; HC: Hip circumference; IGFIR: Insulin-like growth factor ...
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Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004
... catabolic factor, IL-1 might also be anabolic (as discussed by ...factors, extracellular matrix synthesis, assembly and degradation, all of which may be affected by the genetic background and ...
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