extravillous trophoblast
Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
... in trophoblast cells includ- ing the HTR8/SVsno have been demonstrated [31,32], it is therefore possible that activin-A may regulate its receptor expression at the level of gene ...
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IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells
... Background: Adverse gestational outcomes such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are associated with placental insufficiency. Normal placental development relies on the insulin-like growth ...
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S100P enhances the motility and invasion of human trophoblast cell lines
... the extravillous populations of the anchoring columns, with an overall expression seen to be at its highest during the early stages of implantation in the first trimester of ...HTR8/SVneo extravillous ...
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Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model
... The HPA-1a epitope is formed by only one amino acid change, L33P, in integrin β3, and, therefore, all anti- HPA-1a antibody epitopes overlap reacting with the L33 residue. Yet, anti-HPA-1a antibodies are reported to be ...
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Isolation and characterization of human placental trophoblast subpopulations from first-trimester chorionic villi.
... the extravillous trophoblast population ex- presses mesenchymal-type integrins a 1, a 3, and a 5, high levels of b 1, and vitronectin receptors, as has also been reported by others (5, 13) and which has ...
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Vol 68, No 4 (2016)
... pathway, extravillous trophoblast cells undergo a change in phenotype ...[2]. Trophoblast cells invading from the anchoring chori- onic villi of the placenta into the uterus lose the adhe- sion ...
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Copper Nanoparticles Show Obvious in vitro and in vivo Reproductive Toxicity via ERK Mediated Signaling Pathway in Female Mice
... human extravillous trophoblast cells and in the reproductive organs of ...human extravillous trophoblast cells and caused cell cycle arrest at the G2/M phase in a time-and dose-dependent ...
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Control of human trophoblast function
... The trophoblast, ...distinct trophoblast cell types begins, namely the villous and the extravillous trophoblast, the former of which is devoted to fetal-maternal exchanges and the latter binds ...
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Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
... by extravillous trophoblast, may thus be to fine- tune innate immunity by modulating macrophage func- tion and indirectly inhibiting the activity of maternal NK and NK-like cells via HLA-E ...
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Immunohistochemical Expression of Myeloperoxidase in Placental Samples of Systematic Lupus Erythematosus Pregnancies
... Our findings proposed that an elevated MPO expression level in placenta tissue probably could be a key factor that triggers PE in pregnant SLE patients. Finally, we concluded that the immunohistochemical expression ...
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Human cytomegalovirus infection inhibits CXCL12 mediated migration and invasion of human extravillous cytotrophoblasts
... The human extravillous trophoblast cell line SGHPL-4 (kindly provided by Drs. Guy Whitley and Judith Cartwright, St. George’s University, London, England) was used for these studies. This cell line was ...
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Original Article CUL4A enhances human trophoblast migration and is associated with pre-eclampsia
... In human placenta, degradation of ECM is involved during extravillous trophoblast cells migration/invasion. In this study, CUL4A siRNA was demonstrated to be able to decrease the gelatinolytic activities of ...
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Application of Trophoblast in Noninvasive Prenatal Testing
... Collecting Trophoblast Cells from Maternal Peripheral Blood: As early as 1893, Schmorl [4] discovered trophoblast cells in the lungs of corpse pregnant women with ...of trophoblast cells can be found ...
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Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high and low quality human embryos
... a trophoblast spheroid, the migration of decidualized H-EnSCs from women with RM was significantly more extensive compared to the decidualized H-EnSCs of normally fertile women ...a trophoblast spheroid was ...
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The umbilical cord, preeclampsia and the VEGF family
... MMP1 was positive and very specific in the trophoblast beneath the basal plate 20 × (Figure 5A). The expression was frequent but weak in the smooth muscle of chorionic vessels and in chorionic stromal cells ...
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Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA C2
... miscarriage, trophoblast invasion is most severely deficient and the placenta is subjected to over- whelming oxidative stress, with fetal loss late in the first ...alone, trophoblast invades much further ...
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11ß HSD2 dependent and independent signalling pathways in trophoblast biology and glucocorticoid responsiveness
... In order to monitor the fusion process of BeWo cells, three different methods (brightfield microscopy with nuclei staining, fluorescent membrane staining, fluo- rescent cell tracker staining) were used since the ...
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Inhibition of TGF β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies
... architecture is maintained. Placental villous explants in culture preserve the topology of intact villi and mimic closely the formation of anchoring villi occurring in vivo during the first trimester of pregnancy (27, ...
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Aberrantly Up-regulated miR-20a in Pre-eclampsic Placenta Compromised the Proliferative and Invasive Behaviors of Trophoblast Cells by Targeting Forkhead Box Protein A1
... of trophoblast cell proliferation, migration and inva- sion(14, 15, ...of trophoblast cells by suppressing the expression of Ephrin-A3 and Home- obox-A9, which related with cell migration and vas- cular ...
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Original Article Expression of uPAR in human trophoblast and its role in trophoblast invasion
... in trophoblast syncytializa- ...regulate trophoblast cell fusion [6, 29, ...in trophoblast syncytial- ization, the detailed mechanism needs further ...
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