Extrinsic Apoptosis
RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways
... evading apoptosis of tumor cells may result in chemotherapy ...drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and ...
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Evodiamine Induces Extrinsic Apoptosis Through P38 Mapk Pathway and Inhibits Autophagy in Gallbladder Cancer
... promoting extrinsic apoptosis with related caspases activation through p38 MAPK pathway and inhibited autophagy in a dose-dependent manner in vitro and ...
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TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells
... cell apoptosis in ...-induced extrinsic apoptosis through activating calpain/IAP/caspase3 ...cell apoptosis and suggests that increasing the level of cytosolic Ca 2+ might be an alternative ...
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The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5
... CFZ-induced apoptosis and enhancement of TRAIL-induced apoptosis and the mechanism accounting for CFZ-induced DR5 ...CFZ-induced apoptosis and enhancement of TRAIL- induced apoptosis, since ...
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So Cheong Ryong Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non small cell lung cancer A549 cells
... cell apoptosis in vitro ...intrinsic apoptosis pathway. SCRT also activates the extrinsic apoptosis pathway by increasing both TRAIL and FasL, resulting in the activation of caspase-8 and Bid ...
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PubMedCentral-PMC5328506.pdf
... necroptosis, apoptosis and NETosis defend against infection in ...cell extrinsic apoptosis, but also may trigger necroptosis, cause a lymphoproliferative disorder, and inhibit innate immune receptor ...
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Retama monosperma n hexane extract induces cell cycle arrest and extrinsic pathway dependent apoptosis in Jurkat cells
... cellular apoptosis, predominantly acting via the extrinsic apoptosis pathway, with a strong selectivity against human T cell ...induces apoptosis is likely to involve a JNK/Fas-L/caspase 8/ ...
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Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
... the extrinsic apoptosis cascade activated by death inducing ligands like TRAIL is much more ...sic apoptosis induction and the distribution of the three phenotypes was nearly equal between cell lines ...
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
... of extrinsic apoptosis driven by death receptors follows two distinct ...[310], extrinsic apoptosis requires the proteolytic cleavage of BID by CASP8 [70, 311, ...of apoptosis 1 (MOAP1) ...
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<p>6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway</p>
... the extrinsic apoptosis and endoplasmic reticulum (ER) stress pathways by PNAP-6 were analyzed by annexin-V/propidium iodide flow cytometric analysis, Hoechst 33342 fluorescent staining, and Western ...
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Necroptosis: a regulated inflammatory mode of cell death
... of extrinsic apoptotic pathway ...shift extrinsic apoptosis to necrosis mode of cell death due to activation of RIPK3 and MLKL ...activates apoptosis by blocking the necroptosis and by ...
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The effect of Astragalus polysaccharides on attenuation of diabetic cardiomyopathy through inhibiting the extrinsic and intrinsic apoptotic pathways in high glucose stimulated H9C2 cells
... process. Apoptosis is mediated mainly by the extrinsic apoptotic pathway and the intrinsic apoptotic pathway [13, ...35]. Extrinsic apoptosis is initiated through ligand-mediated activation of ...
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Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells
... drug-induced apoptosis, death receptor-dependent and mitochondria-dependent path- ways ...receptor apoptosis pathway or the extrinsic pathway had been thought to involve only the caspase cascade in ...
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CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways
... lymphocyte apoptosis with high levels of soluble Fas lig- and (sFasL) in human malaria, the involvement of the Fas/ FasL system has not been observed in experimental models of malaria ...studies, apoptosis ...
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Mechanism of metastasis suppression by luteolin in breast cancer
... Abstract: Metastatic breast cancer is typically an extremely aggressive cancer with poor prog- nosis. Metastasis requires the orchestration of homeostatic factors and cellular programs, many of which are potential ...
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Role of ceramide in diabetes mellitus: evidence and mechanisms
... Lipid rafts are specialized micro-domains of plasma membrane that contain high concentrations of lipid de- rived molecules such as cholesterol, sphingolipids and a subset of phospholipids [154]. Sphingomyelin is the most ...
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Cistanche tubulosa phenylethanoid glycosides induce apoptosis in H22 hepatocellular carcinoma cells through both extrinsic and intrinsic signaling pathways
... of apoptosis, H22 cells were treated with different concentrations of CTPG (0, 100, 200, 300 and 400 μg/ml) for 24 h and stained with PI and Annexin ...induced apoptosis of H22 cells (including early and ...
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The Human Papillomavirus Type 16 E5 Protein Impairs TRAIL- and FasL-Mediated Apoptosis in HaCaT Cells by Different Mechanisms
... As already mentioned HPV-16 belongs to the high-risk types which infect the genital mucosa. Proliferation and regression of gynecological tissues such as ovary, endometrium and cervix is hormone dependent, and Fas is ...
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Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
... death receptor pathway [32,33]. In the intrinsic pathway, many factors such as environmental changes, stimuli and drugs could induce mitochondria dysfunction. Cyto- chrome c is released from dysfunctional mitochondria ...
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Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function
... Recent studies have shown that members of the inhibitor of apoptosis (IAP) protein family are highly expressed in several classes of cancer. The primary implication of these findings is that the elevated ...
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