Fab Fragments
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
... 8 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Recognition Properties of a Panel of Human Recombinant Fab Fragments to the CD4 Binding Site of gpl20 That Sho[r] ...
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Preparation of Recombinant Human Monoclonal Antibody Fab Fragments Specific for Entamoeba histolytica
... DNA fragments were ligated with a plasmid vector and were introduced into Escherichia ...three Fab fragments with different DNA sequences were found to react with all nine strains and another ...
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Recognition by recombinant autoimmune thyroid disease derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase
... SP Fab fragments are present in all 11 patients studied, constitute a high proportion (36- 72%) of serum TPO autoantibodies in individual patients and interact with a conformational epitope on ...
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Localization of 131I labeled p97 specific Fab fragments in human melanoma as a basis for radiotherapy
... 131I-labeled Fab fragments specific for p97, an oncofetal glycoprotein of human ...131I-labeled Fab specific for p97, and an 125I-labeled Fab not specific for ...p97-specific Fab was ...
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Dissection of Epitope-Specific Mechanisms of Neutralization of Influenza Virus by Intact IgG and Fab Fragments
... (Fab) fragments in complex with soluble, isolated antigen constructs ...of Fab-HA complexes, it is usually inferred that the blockage of receptor binding sites or inhibition of conformational changes ...
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Effects of sheep digoxin specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs
... their Fab fragments have both been found to exert profound effects on digoxin pharmacokinetics in [3H] digoxin-treated ...in Fab-treated dogs, with significant quantities of digoxin being excreted ...
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Reversal of Advanced Digitoxin Toxicity and Modification of Pharmacokinetics by Specific Antibodies and Fab Fragments
... specific Fab fragments intravenously over 3 min, followed by a 30-min infusion of one-third of the initial ...initial Fab infusion, and stable normal sinus rhythm was present at 54±16 ...initial ...
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Neutralizing Human Fab Fragments against Measles Virus Recovered by Phage Display
... soluble Fab fragments. To screen for antigen-specific Fab clones, 20 colonies each from the first and second pannings of library A, 30 colonies from the panning of library B, and 80 and 120 colonies ...
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Fab Fragments of Digoxin-Specific Antibodies Used to Reverse Ventricular Fibrillation Induced by Digoxin Ingestion in a Child
... Fab Fragments of Digoxin-Specific Antibodies Used to Reverse Ventricular. http://pediatrics.aappublications.org/content/70/3/468[r] ...
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HIV 2 neutralization by intact V3 specific Fab fragments
... on the potent neutralization effect of Fabs compared to mAbs [16,17] prompted us to study the effect of the size of mAbs on HIV-2 neutralization capacity. Both 7C8 and 3C4 were digested using papain, and the different ...
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Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody
... 2H2 Fab fragment was fitted into the cryoEM difference map (see Materials and ...the Fab molecule was on top of the pr peptide and consisted primarily of highly exposed a and c strands belonging to two ...
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Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragments.
... The importance of studying several neutralizing monoclonal antibodies became apparent when we found that antibody binding to NImIB, NImIl, and NImlll sites resulted in the polymerization[r] ...
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Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody.
... As predicted in this article, this complex clearly shows MAb17-IA bivalently bound across icosahedral twofold axes, no significant conformational changes in the capsid structure, the con[r] ...
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Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies
... one Fab molecule bound to the same spike ...the Fab molecules, which was only about one-third of the density of the virus capsid (Table ...a Fab fragment one-third of the time, the fitting process ...
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Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria
... antibody Fab fragments (rFabs) reactive to herpes simplex virus (HSV) antigens were selected from a human combinatorial antibody library constructed in a phage-display vector by a panning procedure against ...
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Immunoinhibition of ristocetin induced platelet aggregation
... Monovalent Fab fragments obtained from the isolated gamma-globulin fractions of the antisera blocked ristocetin-induced aggregation of fixed washed platelets in buffer and normal platelets in platelet-rich ...
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Capturing the Natural Diversity of the Human Antibody Response against Vaccinia Virus
... of Fab fragments was performed in 384 deep-well plates essentially as described previously ...The Fab-containing supernatants were cleared by centrifugation and used for screen- ing of individual ...
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Comparative analyses of the specificities of anti-influenza hemagglutinin antibodies in human sera.
... However, since they indicate that sera differ in their abilities to inhibit the binding to virus of different Fab fragments from monoclonal antibodies, they allow the simple conclusion t[r] ...
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Impact of Valency of a Glycoprotein B-Specific Monoclonal Antibody on Neutralization of Herpes Simplex Virus
... and Fab fragments and a recombinant single-chain variable frag- ment (scFv) as valuable tools for studying the hypothesized mechanism mediated by MAb ...
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Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection
... The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective an- tibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly ...
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