Factor IXa
Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse Role of the endothelium and the plasma proteinase inhibitors
... 125I-Factor IXa was bound to ATIII by 1 min. The distribution of 125I-Factor IXa in mouse plasma was ...125I-Factor IXa was rapid (50% clearance in 2 min) and biphasic and was ...
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3D QSAR and Pharmacophore Modelling of Selected Benzimidazole Derivatives as Factor IXa Inhibitors
... worldwide. Factor IXa (FIXa) is also known as Christmas factor, which is a serine protease family enzyme of coagulation cascade discovered in 1952 by Christmas [3] ...
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Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives
... Abstract: Factor IXa (FIXa), a blood coagulation factor, is specifically inhibited at the initiation stage of the coagulation cascade, promising an excellent approach for developing selective and ...
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3D QSAR, PHARMACOPHORE INDENTIFICATION STUDIES ON SERIES OF 4- SUBSTITUTED BENZOTHIOPHENE ANALOGS AS FACTOR IXA INHIBITORS
... the factor IXa inhibition, these features are contributed by the benzothiophene nucleus, which are separated by ...for factor IXa inhibition, in present data set the amidine group is ...
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Active site blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model
... of Factor IX/IXa, to intravascular thrombosis, a canine coronary thrombosis model was ...glutamyl-glycyl-arginyl-Factor IXa (IXai), a competitive inhibitor of Factor IXa assembly ...
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Characterization of the clotting activities of structurally different forms of activated factor IX Enzymatic properties of normal human factor IXa alpha, factor IXa beta, and activated factor IX Chapel Hill
... human Factor IX (Factor IXa alpha and IXa beta) have been previously reported to have essentially identical clotting activity in ...activated Factor IX Chapel Hill, an abnormal ...
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Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review
... Introduction: Anticoagulants are used as preventive agents in deep vein thrombosis to prevent blood clots, venous and arterial thromboembolism, but the current therapy of anticoagulants have several limitations like ...
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Platelet receptor mediated factor X activation by factor IXa High affinity factor IXa receptors induced by factor VIII are deficient on platelets in Scott syndrome
... studied factor IXa binding and factor X activation with normal platelets and with platelets obtained from a patient with a bleeding disorder and an isolated deficiency of platelet procoagulant ...
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Protease nexin 2/amyloid beta protein precursor A tight binding inhibitor of coagulation factor IXa
... When the ability of recombinant KPI domain to inhibit the coagulant activity of pooled normal human plasma was compared to purified whole PN-2/A3PP, which was only available at concentra[r] ...
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Role of human factor VIII in factor X activation
... of Factor Xa, which had no inhibitory activity against Factor IXa, markedly prolonged this lag, whereas specific thrombin inhibitors did not prolong the ...unactivated Factor VIII has no ...
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Kinetics of the Factor XIa catalyzed activation of human blood coagulation Factor IX
... human Factor IX by human Factor XIa was studied by measuring the release of a trichloroacetic acid-soluble tritium-labeled activation peptide from Factor IX by a modification of a method described ...
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A Comparison of Domain based Word Polarity Estimation using different Word Embeddings
... A Comparison of Domain based Word Polarity Estimation using different Word Embeddings Aitor Garc??a Pablos, Montse Cuadros, German Rigau Vicomtech IK4, Vicomtech IK4, IXA research group agarciap@vicom[.] ...
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Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells
... the IXa, reduced the mRNA level of BDNF in psychotic ...BDNF IXa under OGD/R. To validate the methylation status of the BDNF IXa, we designed specific PCR primers for bisulfite sequencing PCR ...the ...
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Towards Semantic based Hybrid Machine Translation between Bulgarian and English
... In order to adapt the semantic processing, we incorporated a Linked Open Data resource (DB- Pedia) in the en ↔ bg experiments via a mapping of the DBpedia ontology to WordNet. Our goal was to use again the IXA ...
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Annotating Abstract Meaning Representations for Spanish
... Annotating Abstract Meaning Representations for Spanish Noelia Migueles Abraira, Rodrigo Agerri, Arantza Diaz de Ilarraza IXA NLP Group, University of the Basque Country UPV/EHU noeliamigueles@gmail c[.] ...
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Syntactic Features for High Precision Word Sense Disambiguation
... Syntactic features for high precision Word Sense Disambiguation Syntactic features for high precision Word Sense Disambiguation David Mart?nez, Eneko Agirre IxA NLP Group University of the Basque Coun[.] ...
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Semiautomatic Labelling of Semantic Features
... Semiautomatic labelling of semantic features Semiautomatic labelling of semantic features Arantza D?az de Ilarraza, Aingeru Mayor and Kepa Sarasola IXA Group Computer Science Faculty University of the[.] ...
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A Multilingual Predicate Matrix
... A Multilingual Predicate Matrix Maddalen Lopez de Lacalle3, Egoitz Laparra?, Itziar Aldabe?, German Rigau? 3 Elhuyar Foundation ? IXA group, University of the Basque Country, UPV/EHU m lopezdelacalle@[.] ...
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Biomedical term normalization of EHRs with UMLS
... Biomedical text mining technologies are becoming a key tool for the efficient exploitation of information contained in unstructured data repositories, including scientific litera- ture, Electronic Health Records (EHRs), ...
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Ixazomib for relapsed or refractory multiple myeloma : review from an evidence review group on a NICE single technology appraisal
... for IXA-LEN-DEX over LEN-DEX calculated from data for the “observed” period of about 30 months would be maintained throughout the further 23 years of the economic model; the ERG suggested this could be an ...
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