Factor VIIa
Pediatric Off-label Use of Recombinant Factor VIIa
... recombinant factor VIIa for off- label ...recombinant factor VIIa were disseminated intravascular coagulation/sepsis (28), surgical bleeding (19), proce- dural prophylaxis (16), and trauma ...
9
An in vitro evaluation of standard rotational thromboelastography in monitoring of effects of recombinant factor VIIa on coagulopathy induced by hydroxy ethyl starch
... 25. Poon MC, d'Oiron R, Hann I, Negrier C, de Lumley L, Thomas A, Karafoulidou A, Demers C, Street A, Huth-Kuhne A, Petrini P, Fressi- naud E, Morfini M, Tengborn L, Marques-Verdier A, Musso R, Deve- cioglu O, Houston ...
6
Use of human factor VIIa in the treatment of two hemophilia A patients with high titer inhibitors
... with Factor VIIa the circumference of the muscle decreased and joint mobility increased ...given Factor VIIa concurrent with tranexamic acid in association with the extraction of two primary ...
7
The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor
... via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participation of tissue factor in this ...recombinant Factor VIIa (approximately ...
7
Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients
... coagulation factor concentrates ineffective, and alternative means must be used to achieve ...Recombinant factor VIIa (rFVIIa) was developed to control bleed- ing episodes in hemophilic patients with ...
11
Overview of the use of recombinant factor VIIa in children
... prothrombin complex concentrate (aPCC) is produced from pooled, donated, virally inactivated plasma, and contains activated factors II, VII, IX, and X. The other bypassing agent is recombinant factor VIIa ...
8
Inhibitor of the factor VIIa tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease
... Inhibition of Factor VIIa-tissue factor activity by a plasma component(s) that requires factor Xa has been described recently. In this communication, we have developed a specific radiometric ...
6
Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
... tissue factor (TF) expression in neutrophils contributes to respiratory burst, trophoblast injury, and pregnancy loss in mice treated with ...TF/Factor VIIa (FVIIa) signaling through PAR2, inhibited ...
10
Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review
... Introduction: Anticoagulants are used as preventive agents in deep vein thrombosis to prevent blood clots, venous and arterial thromboembolism, but the current therapy of anticoagulants have several limitations like ...
8
Use of Recombinant Factor VIIa in Obstetrics
... activated factor VIIa to stabilize haemodynamics has been reported as a temporary measure while awaiting vascular embolization which finally stopped the bleeding ...
14
Cost effectiveness of recombinant factor VIIa for treatment of intracerebral hemorrhage
... Recombinant factor VIIa (rFVIIa) is currently FDA- approved for the treatment of patients with hemophilia. Given its thrombogenic effects, it was hypothesized that it might be useful for limiting clot ...
9
Failure of recombinant factor VIIa in a patient with severe polymicrobial sepsis and postoperative uncontrolled intraabdominal bleeding
... of factor VII or VIIa in plasma after the administration of rFVIIa only proves the exist- ence of factor VII and its successful administration, but it does not predict any effect on haemostasis ...
6
Recombinant activated factor VIIa and hemostasis in critical care: a focus on trauma
... To date, in the USA the largest series is that reported by Dutton and colleagues [18], with more than 80 patients studied, including a previous study of five patients [17]. In their series the indications for use of ...
6
Requirement for binding of catalytically active factor VIIa in tissue factor dependent experimental metastasis
... Experimental metastasis assay. Female C.B-17 severe combined immunodeficient (SCID) mice were purchased from Taconic Farms Inc. (Germantown, NY). Mice were housed under specific pathogen– free conditions and kept on 40 ...
8
Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin Reversal
... 4 factor PCC product available in Europe has completed clinical trials and has recently been ap- proved by the FDA (Kcentra®) for warfarin reversal in patients with acute major ...4 factor PCC product was ...
7
Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage in Children
... abstract Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders, and it has a high mortality rate. The current treatment options ...
7
Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings
... congenital factor VII deficiency undergoing surgery or invasive procedures; and in patients with Glanzmann’s ...In factor VII deficient patients doses of 15–20 µ g/kg have been given every 2–3 hours, ...
8
The utility of recombinant factor VIIa as a last resort in trauma
... additional factor that must be considered is the impact of other variables, such as rate of bleeding and baseline physiologic factors on rFVIIa, particularly tem- ...
6
Off-Label Use of Recombinant Factor VIIa in Pediatric Patients
... WHAT THIS STUDY ADDS: This is the largest reported case series of off-label rFVIIa in pediatric patients from a well-designed, representative, and rigorously audited registry of rFVIIa u[r] ...
10
Critical appraisal of the role of recombinant activated factor VII in the treatment of hemophilia patients with inhibitors
... Abstract: Hemophilia patients with inhibitors faced the constraint of inadequate treatment for several years before the era of recombinant factor VIIa (rFVII). Initially, rFVIIa was used in the ...
12