Factor VIII
Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII
... nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von ...
7
Effects of triiodothyronine induced hypermetabolism on factor VIII and fibrinogen in man
... subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < ...in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol ...
8
Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... In plasma, von Willebrand factor (vWf) associates with Factor VIII (FVIII); however, the site at which these pro- teins first interact has not been defined. Administration of 1-desamino-8- D ...
13
Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease
... plasma Factor VIII/von Willebrand factor (FVIII/vWF) molecule from 16 patients with von Willebrand's disease, and have found no evidence of a significant decrease of carbohydrate content in 15 of ...
6
Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... Comparison of the multimers produced by reduction with the multimers produced by cross- linking, demonstrated the absence of odd-numbered multimers from the reduced series. Thus, the protomeric unit appears to be the ...
9
Acquired Factor VIII Inhibitor in Juvenile Rheumatoid Arthritis
... Acquired circulating inhibitor to factor VIII (FVIII) has been reported in both hemophiliacs and nonhe- mophiliac&.. FVIII inhibitor occurs in 10% to 20% of patients with severe, cla[r] ...
6
Molecular basis of factor VIII inhibition by human antibodies Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid
... to factor VIII have recently been shown to react with discrete regions of the factor VIII light chain (within the C2 domain) and/or the factor VIII heavy chain (within the ...
8
Factor VIII/von Willebrand factor protein Galactose a cryptic determinant of von Willebrand factor activity
... asialo Factor VIII/von Willebrand factor protein with galactose oxidase resulted in a progressive loss of von Willebrand factor activity with no effect on procoagulant ...
5
Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model
... coagulation factor, factor VIII, is frequently complicated by the development of neutralizing ...tissue factor, a known initiator of coagulation, was investigated as a factor ...
7
The Properties of Immune Complexes Formed by Human Antibodies to Factor VIII
... to Factor VIII inactivate its procoagulant activity, they do not form immunoprecipitates when tested with this ...human Factor VIII with four high-titer human anti- Factor VIII, ...
11
Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes
... pig Factor VIII antigen detected Factor VIII antigen in guinea pig plasma and inhibited the von Willebrand factor activity in guinea pig ...detected Factor VIII antigen in ...
9
Treatment of Haemophilia A by Replacement Therapy using Factor VIII Inhibitors
... of factor VIII gene is spotted by the presence on the end of the lengthy arm of chromosomes ...the factor VIII is a polypeptide containing 2332 amino acids (inactivated flowing master ...
7
Detection of Factor VIII Inhibitors in Hemophilia A Patients
... Calculation of Inhibitor level was done by plotting the results of residual factor VIII activity on the y-axis vs. inhibitor units on the x-axis using log/log graph paper. In the Bethesda method, the ...
6
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
... The presence of specific Factor VIII/von Willebrand factor FVIII/vWF binding sites on human platelets has been demonstrated by using 125I-FVIII/vWF and washed human platelets.. Binding i[r] ...
10
Some Effects of Calcium on the Activation of Human Factor VIII/Von Willebrand Factor Protein by Thrombin
... When Factor VIII/von Willebrand factor (FVIII/vWF) protein is rechromatographed on 4% agarose in 0.25 M CaCl 2 , the protein and vWF activity appear in the void volume, but most of the FVIII ...
11
THE SURVIVAL OF FACTOR VIII (ANTIHEMOPHILIC GLOBULIN) AND FACTOR IX (PLASMA THROMBOPLASTIN COMPONENT) IN NORMAL HUMANS
... Half-lives and standard errors of estimate of the second components of the Factor VIII survival curves in five Figure 2 shows the survival curve for Factor normal human recipients VIII i[r] ...
9
A new recombinant factor VIII: from genetics to clinical use
... Abstract: Advances in recombinant technology and knowledge about coagulation factor VIII (FVIII) are building a platform for new therapeutic options in patients with hemophilia A. The development of ...
9
Patient preference for needleless factor VIII reconstitution device: the Italian experience
... An international multicenter postmarketing surveillance study was carried out in nine European countries (Austria, France, Germany, Greece, Hungary, Italy, Spain, Switzerland, and the United Kingdom) to compare the level ...
6
Acquired factor VIII deficiency: two case reports and a review of literature
... recombinant factor VIII is generally ...e.g., factor VIII inhibitor bypassing activity [FEIBA]) or recombinant human factor VIIa (rVIIa; ...
7
Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches?
... Abstract: Hemophilia A (HA) is a common bleeding disorder caused by the deficiency of factor VIII (FVIII) with an incidence of ~1 in 5000 male births. Replacement of FVIII is nec- essary to prevent and ...
7