failing heart
Mitochondrial protein hyperacetylation in the failing heart
... the failing mouse heart (28) revealed a potential mech- anism whereby mitochondrial proteins may be altered at the posttranslational ...the failing heart but not in compensated cardiac ...
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Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart
... human failing heart, we have measured ANP and ANP messenger RNA (ANPmRNA) levels in left ventricular aneurysm obtained at operation, biopsy specimens of left ventricles from dilated cardiomyopathy (DCM) and ...
9
Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study
... global heart failure (HF) simulation was obtained by decreasing myocardial contractility (f,act) of the three ventricular walls to 50% of its normal value, so that LV ejection fraction was ...a failing ...
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Defective lipid metabolism in the failing heart
... the failing heart of guinea pigs with chronic constriction of the ascending ...form failing hearts exhibited (a) a decreased capacity to oxidize palmitic acid (failure = ...the heart (failure ...
9
ACE2 gene expression is up-regulated in the human failing heart
... in heart failure, ANF was studied as a pos- itive ...of heart failure, in accordance with the hypothesis that local production of Ang II is enhanced in the failing ...
7
Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
... and heart failure will require the identifica- tion of new drug targets that serve as nodal regulators to integrate and transmit stress signals to the genome of the cardiac ...and heart failure as a new ...
10
Creatine kinase–mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved
... ATP is required for normal cardiac contractile function, and it has long been hypothesized that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF). Despite experimental and ...
13
Clinically relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion
... We have previously described a cardioprotective protocol termed temperature preconditioning (TP) [3] where a few brief episodes of hypothermic perfusion (at 26°C) inter- spersed with normothermic perfusion (at 37°C) ...
13
Micro-computed tomography for high resolution soft tissue imaging; applications in the normal and failing heart
... the heart creating tangential and radial forces (Greenbaum et ...the heart), with accompanied narrowing (isovolumic phase) prior to blood ...the heart at this stage (Buckberg et ...the heart ...
340
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
... indicating that the increased myocardial expression of Bdh1 observed in HF is specific to cardiac myocytes. Increased delivery of ketone bodies to the heart ameliorates pathological cardiac remodeling and ...
20
NO/redox disequilibrium in the failing heart and cardiovascular system
... the heart and vasculature (26, 29, ...rabbit heart (17), and NO circulates in the blood stream of mam- mals as a NO-derivative of single-reactive thiols in both albumin and hemoglobin (69, ...
10
beta Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes Alteration in channel response to beta adrenergic stimulation in failing human hearts
... probability. Bath application of the purified catalytic sub-unit of PKA to inside-out patches also inhibited IK1 and the inhibition could be antagonized by alkaline phosphatase. When beta-adrenergic modulation of IK1 was ...
13
Excitation contraction coupling in heart: VII Calcium accumulation in subcellular particles in congestive heart failure
... and failing hearts of genetically dystrophic hamsters (BIO ...the failing heart were markedly ...the failing heart was similar to that of the control ...the failing heart ...
10
Syria and the indicators of a ‘manifest failing’
... ‘manifest failing’ is another ex ample of artful language which enables the UN to respond on a ‘case -by- case’ basis – this is its second strength - in that it is widely accepted that there is no ‘one -size-fits- ...
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Effects of experimental heart failure on the capacity of glucagon to augment myocardial contractility and activate adenyl cyclase
... Although glucagon exerts positive inotropic effects in patients with no or mild impairment of cardiac function, similar effects are not consistently observed in patients with chronic heart failure. Accordingly, ...
9
Decreased adrenergic neuronal uptake activity in experimental right heart failure A chamber specific contributor to beta adrenoceptor downregulation
... congestive heart failure has been thought to be caused by agonist-induced homologous ...right heart failure (RHF) produced by tricuspid avulsion and progressive pulmonary artery constriction and 23 ...
10
MyBP-C in cardiac conditions and its potential use as novel biomarker: a review
... A prompt understanding of MyBP-C in term of structure, genetics and functions is of primordial importance and can be helpful to develop therapeutic potential strategies in treatment of HCM, DCM, heart failure, AMI ...
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Changes in gene expression in the intact human heart Downregulation of alpha myosin heavy chain in hypertrophied, failing ventricular myocardium
... the failing human ...nonfailing heart and no MHC isoform changes, this decrease in myosin or myofibrillar ATPase activity has been attributed to other factors that may regulate myosin ATPase activity, such ...
11
Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts
... transcripts obtained from cloned human alpha-actin sequences, and the total amount of sarcomeric actin mRNA was evaluated as a function of total poly(A+)RNA. We found that both isogenes are always coexpressed, and that ...
9
CaMKII and a failing strategy for growth in heart
... congestive heart failure or die suddenly from cardiac ...of heart failure, but the majority of patients with myocardial hypertrophy do not develop heart ...
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