Fas/Apo-1
Anti Fas/APO 1 antibody mediated apoptosis of cultured human glioma cells Induction and modulation of sensitivity by cytokines
... to Fas/APO-1-dependent apoptosis. Sensitivity to Fas/APO-1 antibody-mediated cell killing correlated with cell surface expression of ...of Fas/APO-1 as well ...
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The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo 1) mutations
... Heterozygous mutations of the receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoim- ...
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Protooncogene bcl 2 gene transfer abrogates Fas/APO 1 antibody mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation
... gliomas. Fas/APO-1 antibody-sensitive human glioma cell lines stably transfected with a murine bcl-2 cDNA acquired resistance to Fas/APO-1 antibody-mediated ...
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Amelioration of collagen induced arthritis by CD95 (Apo 1/Fas) ligand gene transfer
... factor Fas/Apo-1 and its ligand (FasL) play pivotal roles in maintaining self-tolerance and immune ...privilege. Fas is ex- pressed constitutively in most tissues, and is dramatically ...
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Lack of cell surface Fas/APO 1 expression in pulmonary adenocarcinomas
... The Fas receptor and ligand initiate an apoptotic ...ated Fas protein expression in 42 primary pulmonary ade- nocarcinomas, and Fas expression and function in the lung adenocarcinoma cell lines A549 ...
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Expression of Fas (CD95/APO-1) Ligand by Human Breast Cancers: Significance for Tumor Immune Privilege
... Fas ligand (FasL) induces apoptotic death of sensitive lym- phoid cells expressing its cell surface receptor, FasR (CD95/ APO-1) (25). FasL-mediated apoptosis of activated lympho- cytes contributes ...
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Screening of Single Nucleotide Polymorphism in CD95 (APO 1/FAS) Promoter Region (G 1377A) in Children with Acute Leukemia
... [1] Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., Trauth, B.C., et al. (1992) Purification and Molecular Cloning of the APO-1 Cell Surface ...
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APO 1/FAS Promoter ( 670A/G) Polymorphisms and Risk of Lupus Nephritis in SLE Egyptian Female Patients
... the APO-1/FAS Promoter gene was digested by MvaI restriction enzyme (provided by Fermentas), the reaction conditions were, ...and 1 μl (2 units) ...
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An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
... whereas Fas ligand (FasL) expression is tightly regulated and restricted to activated T cells, NK cells, and at sites of immune privilege ...[3]. Apo-1/Fas is considered to have an important ...
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Drug induced apoptosis in hepatoma cells is mediated by the CD95 (APO 1/Fas) receptor/ligand system and involves activation of wild type p53
... Upregulation of the CD95 system might therefore be a ma- jor cause of apoptosis in anticancer therapy. We could show that anticancer drugs with different mechanisms of action, like cisplatin and methotrexate, do also ...
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Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)
... (1994a) Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. Darnay BG, Singh S, Chaturvedi MM, Ag-[r] ...
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Regression of basal cell carcinoma by intralesional interferon alpha treatment is mediated by CD95 (Apo 1/Fas) CD95 ligand induced suicide
... of 1:100 for 25 ...of 1:15 at room temperature for 1 h, washed in PBS, and incubated either with a 1:200 dilution of peroxidase-conjugated goat anti–rabbit IgG (Sigma Chemie AG, Buchs, ...
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Inhibition of Tumor Necrosis Factor Alpha by an Adenovirus-Encoded Soluble Fusion Protein Extends Transgene Expression in the Liver and Lung
... or Fas (APO-1, CD95) have prolonged expression of an Ad transgene expressing a foreign protein in the ...or Fas would have the same effect in normal mice, we created transgenes that expressed ...
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Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
... NaCl, 1 mM EDTA, 1% Triton X-100, 20% glycerol, 5 mM 2-mercaptoethanol, 1 mM phenylmethylsulfonyl fluoride, 100 U/mL aprotinin, 15 mM NaF, and 3 mM sodium ...used: Fas (polyclonal C-20; Santa ...
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Involvement of the CD95 (APO 1/Fas) receptor and ligand system in Helicobacter pylori induced gastric epithelial apoptosis
... In situ hybridization of CD95L mRNA in gastric biopsies Paraformaldehyde-fixed cryosections were dehydrated through an ascending series of ethanol and air dried. Digoxigenin-labeled anti- sense RNA corresponding to the ...
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... of Fas (CD95 / APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lympho- cytes resident within the intestinal lamina propria, a ...
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The apoptosis 1/Fas protein in human systemic lupus erythematosus
... of APO-1 on freshly isolated blood mononuclear cells and on lymphocytes activated in vitro using flow cytometry and the monoclonal antibody ...of APO-1 expression were detected on freshly ...
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Five year financial analysis of two commercial farms converting to organic: 2000 2005
... the FAS average through the whole period, with the reduction in medicine costs being offset by a high level of herd monitoring for health and quality ...the FAS scheme, although income was greatly reduced ...
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Serum neutrophil gelatinase associated lipocalin and resistin are associated with dengue infection in adults
... Infection with any dengue serotype causes a wide spectrum of symptoms, ranging from a mild flu-like syn- drome (dengue fever) to a severe syndrome (dengue hemorrhagic fever and dengue shock syndrome) [2]. On- set of ...
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Prolonged postprandial responses of lipids and apolipoproteins in triglyceride rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele
... an apo E3/3 and E4/3 phenotype were confirmed by the second challenge meals given on day 29 when one-half of each group was given the PUFA-rich or the SFA-rich challenge meal ...the apo E3/3 ...phenotype ...
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