Fas/APO-1/CD95
The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo 1) mutations
... receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoim- ...defective ...
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Expression of Fas (CD95/APO-1) Ligand by Human Breast Cancers: Significance for Tumor Immune Privilege
... Fas ligand (FasL) induces apoptotic death of sensitive lym- phoid cells expressing its cell surface receptor, FasR (CD95/ APO-1) (25). FasL-mediated apoptosis of activated lympho- cytes ...
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Screening of Single Nucleotide Polymorphism in CD95 (APO 1/FAS) Promoter Region (G 1377A) in Children with Acute Leukemia
... The CD95 (Apo-1/Fas) receptor-ligand system is one of the key regulators of apoptosis and is particularly important for the maintenance of lymphocyte ho- ...The CD95 receptor (also ...
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Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)
... (1994a) Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. Darnay BG, Singh S, Chaturvedi MM, Ag-[r] ...
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Involvement of the CD95 (APO 1/Fas) receptor and ligand system in Helicobacter pylori induced gastric epithelial apoptosis
... for CD95 im- munohistochemistry or stored at 2 80 8 C until ...infiltration; 1, mild; 2, moderate; and 3, marked infiltration) and mononuclear cells (0, no infiltration; 1, mild; 2, moderate; 3, ...
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Drug induced apoptosis in hepatoma cells is mediated by the CD95 (APO 1/Fas) receptor/ligand system and involves activation of wild type p53
... the CD95 system is complex and involves expression of membrane-bound or soluble CD95 receptor or ligand, a sensitive CD95 receptor signaling pathway and a bal- ance of pro-apoptotic and ...
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Inhibition of Tumor Necrosis Factor Alpha by an Adenovirus-Encoded Soluble Fusion Protein Extends Transgene Expression in the Liver and Lung
... or Fas (APO-1, CD95) have prolonged expression of an Ad transgene expressing a foreign protein in the ...or Fas would have the same effect in normal mice, we created transgenes that ...
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Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
... presence or absence of an agonistic anti-Fas IgM antibody. Apoptosis of B-CLL cells was quantified by morphologic criteria (Figure 4). Spontaneous apoptosis at 24 hours ranged from less than 0.5% to 39%. Different ...
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Regression of basal cell carcinoma by intralesional interferon alpha treatment is mediated by CD95 (Apo 1/Fas) CD95 ligand induced suicide
... express CD95 ligand, but not the recep- tor, which may allow tumor expansion by averting the at- tack of activated CD95 receptor–positive lymphoid effector ...The CD95 ligand of BCC cells is ...
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Amelioration of collagen induced arthritis by CD95 (Apo 1/Fas) ligand gene transfer
... factor Fas/Apo-1 and its ligand (FasL) play pivotal roles in maintaining self-tolerance and immune ...privilege. Fas is ex- pressed constitutively in most tissues, and is dramatically ...
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TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas mediated liver damage and lethality
... in Fas-induced (CD95/Apo-1–induced) hepatocyte apoptosis and liver ...amplified Fas-induced cell ...anti- Fas–induced hepatocyte apoptosis through the activation of JNK and its ...
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... of Fas (CD95 / APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lympho- cytes resident within the intestinal lamina ...
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An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
... The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor ...Both Fas and Fas ligand (FasL) are ...
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VEINCTR-N, an Immunogenic Epitope of Fas (CD95/Apo-I), and Soluble Fas Enhance T-cell Apoptosis in vitro. II. Functional Analysis and Possible Implications in HIV-1 Disease
... of Fas-L, resulting in the autocrine activation of Fas ...of Fas were able to up-regulate both Fas-L ex- pression and release by chronically activated Fas-positive T-cell lines, it is ...
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Immunogenicity of an Eight Amino Acid Domain Shared by Fas (CD95/Apo-I) and HIV-1 gp120. I. Structural and Antigenic Analysis
... of Fas in sera, supporting the hypothesis that excessive solubilization of the receptor can prime the production of autoanti- ...of Fas; whereas, no correlation is observed (Fig. 1) for its adjacent ...
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Fas/CD95 Induced Chemokines Can Serve as "Find Me" Signals for Apoptotic Cells
... implicated Fas receptor stimulation as a trigger for the production of chemokines and cytokines from vascular smooth muscle cells, macrophages, neutrophils, and dendritic cells (Schaub et ...of Fas ligand ...
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Molecular Basis of Cytotoxicity of Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) in EBV Latency III B Cells: LMP1 Induces Type II Ligand-Independent Autoactivation of CD95/Fas with Caspase 8-Mediated Apoptosis
... by Fas or by cytotoxic compounds, such as etoposide and cisplatin (61, ...receptor Fas, as demonstrated in LMP1-transfected Burkitt lymphoma cell lines (24) or in LCLs (11, ...EBV-induced Fas ...
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Molecular Docking of 4 Tert buthyl bis (2,6 thiomorpholin 4 ylmethyl) 1 phenol (LQM319) on Fas Receptor (CD95)
... of Fas-induced apoptosis in a human lung epithelial cell line, and therefore it is also known as a possible lung fibro- genesis blocker ...in Fas-induced apoptosis by ACE ...and Fas re- ceptor with ...
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The high affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes
... exhibit a similar function, whereas the Bcl-xS isoform has the opposite effect (26–28). In transgenic mice expressing human Bcl-2 in monocytes, these do not undergo apoptosis in the absence of serum and M-CSF (2). Thus, ...
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Original Article Expression and prognostic value of c-Myc and Fas (CD95/APO1) in patients with pancreatic cancer
... of Fas was a negative independent prognostic factor in ...between Fas expression and prognosis [29, ...of Fas expression was correlated with a worse ...of Fas, Fas ligand (FasL) and ...
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