Fas (CD95) ligand, i.e. CD95L
Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum
... scar. CD95 (Fas, APO-1), which was initially identified as a death receptor, and its cognate ligand (CD95L, Fas-L) are both expressed in the ...of CD95L on peripheral myeloid ...
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Sunlight induced basal cell carcinoma tumor cells and ultraviolet B irradiated psoriatic plaques express Fas ligand (CD95L)
... of CD95L is beneficial in maintaining immune privi- lege such that inflammatory and immune-mediated T cell as- saults in the eye are kept to a minimum ...of CD95L to escape from a local immune response that ...
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Regression of basal cell carcinoma by intralesional interferon alpha treatment is mediated by CD95 (Apo 1/Fas) CD95 ligand induced suicide
... via CD95 receptor–CD95 ligand interaction (21–24). CD95 receptor (CD95), a cell sur- face molecule belonging to the TNF receptor superfamily, is expressed on a variety of cell types, ...
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T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.
... of CD95 and its ...Thus, CD95-CD95L (Fas-FasL) interactions are not necessary for either the antigen-specific expansion of T cells, the decline in T-cell numbers, or the induction of apoptosis ...
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Vitamin E inhibits CD95 ligand expression and protects T cells from activation induced cell death
... its ligand (CD95L), a type II transmem- brane protein of the TNF family, is more restricted to a few cell types, such as T cells, macrophages, and cells of the testis (2, ...3). CD95L is not present ...
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Involvement of the CD95 (APO 1/Fas) receptor and ligand system in Helicobacter pylori induced gastric epithelial apoptosis
... of CD95L mRNA in gastric biopsies Paraformaldehyde-fixed cryosections were dehydrated through an ascending series of ethanol and air ...human CD95L was generated by in vitro transcription with T7 polymerase ...
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The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo 1) mutations
... of CD95 function in P6 and 11 could be explained by lack of expression of the mutant proteins and that defective CD95 function of the P4 mutant resulted from failure to bind CD95 ligand ...
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Drug induced apoptosis in hepatoma cells is mediated by the CD95 (APO 1/Fas) receptor/ligand system and involves activation of wild type p53
... the CD95 system is complex and involves expression of membrane-bound or soluble CD95 receptor or ligand, a sensitive CD95 receptor signaling pathway and a bal- ance of pro-apoptotic and ...
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<p>Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies</p>
... The CD95 (Fas or APO-1) receptor is a member of the tumor necrosis factor receptor superfamily and interaction with its natural ligand (CD95L) has been implicated in several pathways of cancer ...
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Pro- and anti-apoptotic CD95 signaling in T cells
... member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune ...by CD95 ligation in activated T cells or other “CD95-sensitive” cell ...inducible ...
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Fas/CD95 Induced Chemokines Can Serve as "Find Me" Signals for Apoptotic Cells
... implicated Fas receptor stimulation as a trigger for the production of chemokines and cytokines from vascular smooth muscle cells, macrophages, neutrophils, and dendritic cells (Schaub et ...of Fas ...
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Species Difference in the Expression of Fas and Fas Ligand in Mature Mammalian Spermatozoa
... Immunofluorescence microscopy. All the pro- cedures were conducted at room temperature unless otherwise specified. Indirect immunofluo- rescence staining for Fas and FasL was performed as described by Perticarari ...
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The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis.
... binding buffer at 4°C. Cells were incubated with 10 m g of anti-human Fas antibody (UB2; Kamiya Biomedical Company), anti-LT b receptor (anti-LT b R) antibody (BDA8; a gift from J. Browning, Biogen), or ...
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... that Fas cross-linking activates an acidic sphingomyelinase in promye- locytic leukemia U937 cells, resulting in ceramide production and apoptotic cell death ...T-PBL, Fas cross-linking induces apoptosis in ...
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Essential roles of the Fas Fas ligand pathway in the development of pulmonary fibrosis
... of Fas and FasL expression in bronchiolar and alveolar epithelial cells and in infiltrating lymphocytes or granulocytes, respec- tively, in lung tissue from patients with IPF ...
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Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)
... (1994a) Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. Darnay BG, Singh S, Chaturvedi MM, Ag-[r] ...
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Posttranslational regulation of Fas ligand function
... receptor Fas results in an increased recruitment of FasL to these membrane micro- domains [64] and chemical disruption of rafts reduces the cytotoxic potential of the cells tested ...effective Fas signal ...
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VEINCTR-N, an Immunogenic Epitope of Fas (CD95/Apo-I), and Soluble Fas Enhance T-cell Apoptosis in vitro. II. Functional Analysis and Possible Implications in HIV-1 Disease
... activation pathway, we included a parallel cell suspension incubated with TNF at the func- tional dose of 10 ng/ml as a positive control to look for any discrepancy in expression be- tween the Fas and the TNF ...
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Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats
... detect Fas, tissue sections were initially treated with 1% SDS in TBS (100 mM Tris-HCl, pH ...anti-human Fas/CD95/APO-1 (Transduction Lab- oratories, Lexington, Kentucky), ...human Fas ...
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Antigen presenting cells expressing Fas ligand down modulate chronic inflammatory disease in Fas ligand–deficient mice
... Thus, Fas-mediated apop- tosis is not a limiting factor in viral clearance and is not the underlying cause of the persistent inflammation exhibited by the MCMV-infected B6-gld/gld ...
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