Fas-Ligand
Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor α in periarticular tenocytes from patients with knee joint osteoarthritis
... Apoptosis of tenocytes. (a) As determined by the levels of cytoplasmic histone-associated DNA fragments, tenocytes from osteoarthritis (OA) patients (n= 5) exhibited a 1.6-fold higher rate of spontaneous apoptosis than ...
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Herpes simplex virus type 2 inhibition of Fas ligand expression.
... Because Fas ligand is expressed in T lymphocytes and be- cause HSV-2 is known to be able to infect T cells (4, 20, 29, 32), we tested whether the virus could inhibit Fas ligand activity in ...
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Reduced Fas ligand expressing splenic CD5+B lymphocytes in severe collagen induced arthritis
... the Fas death receptor (CD95) by Fas ligand (FasL, CD95L, or CD178) [17] and is dependent on activation of the target ...in Fas or FasL lead to severe lymphoproliferative disease in mice, ...
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Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis
... pannus. Fas ligand is critical to the homeostatic regulation of the immune response, but its role in the angiogenic process of RA remains to be ...soluble Fas ligand (sFasL) induces ...
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Antigen presenting cells expressing Fas ligand down modulate chronic inflammatory disease in Fas ligand–deficient mice
... that Fas-FasL interactions are required for down- modulation of an inflammatory response after the clearance of ...of Fas, as the inflam- matory response in MCMV-infected B6-lpr/lpr mice (18) cannot be ...
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Proinflammatory consequences of transgenic Fas ligand expression in the heart
... of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues can result in severe neutrophil infiltration and tissue ...of Fas and FasL in Tg hearts, neither ...
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... of Fas (CD95 / APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lympho- cytes resident within the intestinal lamina propria, a major site of ...
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Elimination of rheumatoid synovium in situusing a Fas ligand 'gene scalpel'
... Surgical synovectomy to remove the inflammatory synovium can temporarily ameliorate rheumatoid inflammation and delay the progress of joint destruction. An efficient medically induced programmed cell death (apoptosis) in ...
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Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice
... of Fas-mediated cytotoxicity in the pathogenesis of mice infected with ...of Fas on the target cell by Fas ligand (FasL) (for a review, see reference ...the Fas gene (lpr) or a point ...
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Species Difference in the Expression of Fas and Fas Ligand in Mature Mammalian Spermatozoa
... the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported ...
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The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft versus host disease
... Thymic graft-versus-host disease (tGVHD) can contribute to profound T cell deficiency and repertoire restric- tion after allogeneic BM transplantation (allo-BMT). However, the cellular mechanisms of tGVHD and inter- ...
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Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
... genes, fas and fas ligand ( fasL ), are candidate contributory genes in human SLE, as mutations of these genes result in autoim- munity in several murine models of this ...humans, fas ...
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Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?
... of Fas ligand (FasL/CD95L) by human astrocytoma and the efficient killing of Fas-bearing cells by astrocytoma lines in vitro and by tumor cells ex ...to Fas 1 cells which include infiltrating ...
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Roles of Fas and Fas ligand during mammary gland remodeling
... both Fas and FasL had a primarily mem- branous ...for Fas and FasL was not homogeneous, even in the same gland or duct (Figures 4 and ...(e.g., Fas/FasL) trigger graded PCD and decreased milk pro- ...
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Serum neutrophil gelatinase associated lipocalin and resistin are associated with dengue infection in adults
... soluble Fas [sFas], sol- uble Fas ligand [sFasL], soluble vascular cell adhesion molecule 1 [sVCAM-1], and total plasminogen activator inhibitor-I [tPAI-I]) (Millipore, Billerica, MA, USA), MILLIPLEX ...
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γδ T Cells Promote a Th1 Response during Coxsackievirus B3 Infection In Vivo: Role of Fas and Fas Ligand
... soluble Fas (CD95) and Fas ligand (FasL) predict disease course in pa- tients with acute myocarditis, with the highest levels of these factors occurring in patients with a fatal outcome ...(11). ...
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The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection
... a Fas susceptible peripheral T lymphocyte is depleted by a FasL-expressing immune cell is unknown ...to Fas-medi- ated signaling and FasL expression by the lymphocyte within hours resulting in its death by ...
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The contrasting roles of IL 2 and IL 15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases
... in Fas-mediated activation-induced cell death (AICD) of CD4 T cells ...molecule Fas ligand (FasL). The interaction of FasL with Fas then leads to death of the self-reactive T cells ...
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Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression
... Whereas this experiment confirmed that mFasL augmenta- tion could enhance cell killing via physiologic pathways of cellular interaction, we also sought to demonstrate the conse- quences of Fas and FasL ...
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Essential roles of the Fas Fas ligand pathway in the development of pulmonary fibrosis
... the Fas-FasL pathway, appear to be required to dam- age the ...the Fas-FasL pathway is an important contributor to the patholog- ical grade, apoptosis, and pulmonary fibrosis induced by ...
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