Fas Ligand (CD178)
Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway
... cells. Fas (DR2/CD95/Apo-1) is a type I cell membrane protein with an extracellular domain that binds Fas ligand (Fas-L) and a cytoplasmic domain that transduces the death signal ...[19,20]. ...
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Amelioration of collagen induced arthritis by CD95 (Apo 1/Fas) ligand gene transfer
... encoding Fas or FasL lead to lymphocytic proliferation and autoimmune in- flammatory diseases ...(3–5). Fas is expressed constitutively in most tissues (5) and is dramatically upregulated at the site of ...
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Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?
... of Fas ligand (FasL/CD95L) by human astrocytoma and the efficient killing of Fas-bearing cells by astrocytoma lines in vitro and by tumor cells ex ...
7
Antigen presenting cells expressing Fas ligand down modulate chronic inflammatory disease in Fas ligand–deficient mice
... that Fas-FasL interactions are required for down- modulation of an inflammatory response after the clearance of ...of Fas, as the inflam- matory response in MCMV-infected B6-lpr/lpr mice (18) cannot be ...
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Herpes simplex virus type 2 inhibition of Fas ligand expression.
... assess Fas ligand surface expression, we used a biotinylated mouse monoclonal antibody specific for human Fas ligand, NOK-1 (19), and biotinylated control immuno- globulin G1 (IgG1) antibodies ...
5
Elimination of rheumatoid synovium in situusing a Fas ligand 'gene scalpel'
... Surgical synovectomy to remove the inflammatory synovium can temporarily ameliorate rheumatoid inflammation and delay the progress of joint destruction. An efficient medically induced programmed cell death (apoptosis) in ...
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Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
... genes, fas and fas ligand (fasL), are candidate contributory genes in human SLE, as mutations of these genes result in autoimmunity in several murine models of this ...humans, fas mutations ...
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Proinflammatory consequences of transgenic Fas ligand expression in the heart
... of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues can result in severe neutrophil infiltration and tissue ...of Fas and FasL in Tg hearts, neither ...
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γδ T Cells Promote a Th1 Response during Coxsackievirus B3 Infection In Vivo: Role of Fas and Fas Ligand
... soluble Fas (CD95) and Fas ligand (FasL) predict disease course in pa- tients with acute myocarditis, with the highest levels of these factors occurring in patients with a fatal outcome ...(11). ...
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Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis
... pannus. Fas ligand is critical to the homeostatic regulation of the immune response, but its role in the angiogenic process of RA remains to be ...soluble Fas ligand (sFasL) induces ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... [10]. Fas ligand (FasL CD95L), a membrane molecule, belonging to the TNF family, interacts with Fas (CD95/Apo-1)—a cell surface receptor that is regulated by their soluble forms sFasL and sFas, ...
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Neutrophil Suppresses Tumor Cell Proliferation via Fas /Fas Ligand Pathway Mediated Cell Cycle Arrested
... the Fas ligand /Fas signal transduction leads to tumor cell cycle arrest with using Fas receptor antagonist and Fas knock out cell ...
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Status of FAS and FAS Ligand Gene Polymorphisms in Patients wi th Breast Cancer in Northeastern IRAN
... L. FAS and FAS- Ligand Promoter Polymorphisms in Hepatitis B Virus ...al. FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case– control ...of FAS and FASL gene ...
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Oxidative stress increases Fas ligand expression in endothelial cells
... soluble Fas ligand retains its capacity to interact with Fas, and serum concen- trations of soluble FasL are related to the development of vascular ...
8
Decitabine immunosensitizes human gliomas to NY ESO 1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway
... of Fas and possibly other death receptors [38]. Fas/FasL is an extrinsic death pathway that induces apoptosis upon tri- merization of Fas after binding to FasL leading to the recruitment of ...
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Soluble Fas Ligand as a Potential Marker of Severity of Dengue Infection
... soluble Fas ligand level in DHF patients compared to DF patients, and a significant difference (P = ...soluble Fas ligand level in DF patients compared to the control ...of Fas ...
5
Posttranslational regulation of Fas ligand function
... member Fas ligand acts as a prototypic death ...in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential effector functions of the immune ...addition, Fas ...
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The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection
... Fas/Fas Ligand (FasL) interactions play a significant role in peripheral T lymphocyte homeostasis and in certain patho- logical states characterized by T cell ...
13
Species Difference in the Expression of Fas and Fas Ligand in Mature Mammalian Spermatozoa
... the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported ...
8
Scholl, Nina (2009): Sekretion und Oberflächenexpression von CD137L (4-1BBL) und CD178 (Fas-Ligand) und deren prognostische Relevanz bei Patienten mit MDS, AML und NHL. Dissertation, LMU München: Medizinische Fakultät
... Um die Menge an l¨ oslichem Faktor CD178 nachzuweisen, wurden 96 well Plat- ten ¨ uber Nacht bei 4 ◦ C mit 100 µl des capture Ab Klon 4H9 mit 1,0 µg/ml pro well bebr¨ utet. Nach abgeschlossener Inkubation f¨ ugten ...
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