Fatty acid amide hydrolase (FAAH)
Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells
... of fatty acid amide hydrolase (FAAH) which catalyzes the degradation of endocannabinoids (anandamide [AEA], 2-arachidonoylglycerol [2-AG]) and endocannabinoid-like substances ...
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The Biochemical Fundamental Biomarkers of The Status of Health Against Cancer and Cardiovascular Diseases: Presence of Cortisol and Melatonin Circadian Rhythms, Normal Blood Levels of Fatty Acid Amide Hydrolase (FAAH) and Transforming Growth Factor-Beta (TGF-Beta), and Normal Values of Lymphocyte-to-Monocyte Ratio (LMR) and Atrial Natriuretic Peptide (ANP)-to-Endothelin-1 (Et-1) Ratio
... of fatty acid amide hydrolase (FAAH), whose increase is associated with an endocannabinoid system deficiency, normal lymphocyte-to-monocyte ratio (LMR) values, normal blood levels of ...
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The fatty acid amide hydrolase inhibitor URB597 exerts anti inflammatory effects in hippocampus of aged rats and restores an age related deficit in long term potentiation
... by fatty acid amide hydrolase (FAAH) and 2-arachido- noylglycerol (2-AG), which is hydrolyzed by FAAH and monoacylglycerol lipase (MAGL) ...[3,4]. FAAH also catalyzes the ...
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Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end stage osteoarthritis pain and peripheral neuropathy in mice
... as fatty acid amide hydrolase (FAAH) which renders them physiologically ...of FAAH bioactivity could reduce OA-associated inflammation and joint ...the FAAH inhibitor ...
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Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice
... The potent regulatory properties of NKT cells render this subset of lipid-specific T cells a promising target for immunotherapeutic interventions. The marine sponge glycolipid a- galactosylceramide (aGalCer) is the proto ...
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The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans
... of FAAH mRNA expression in human adipose tissue have been measured by multiple laboratories and conflicting findings have been ...studies, FAAH mRNA is reported to be higher in the subcuta- neous adipose ...
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Emmerdinger, Dominik (2009): Die Rolle des Enzyms Fatty Acid Amide Hydrolase (FAAH) und von Varianten des FAAH Gens bei chronisch entzündlichen Darmerkrankungen. Dissertation, LMU München: Medizinische Fakultät
... In mehreren Untersuchungen konnte ein Zusammenhang zwischen dem FAAH C385A Polymorphismus und dem Vorhandensein einer Adipositas belegt werden. Daher kam für einige Forscherteams auch die Überlegung auf, ob es ...
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Fatty acid amide hydrolase deficiency limits early pregnancy events
... of FAAH, we examined the expres- sion profiles of Cdx2, Nanog, and Oct3/4, known key transcription factors involved in lineage specification in early embryos ...
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3D-QSAR on a series of pyrimidinyl-piperazine- carboxamides based Fatty Acid Amide Hydrolase (FAAH) inhibitors as a useful tool to obtain novel endocannabinoid enhancers
... Endogenous FAAH substrates such as anandamide serve key regulatory functions in the body and have been implicated in a variety of pathological conditions, including pain, anxiety, depression and vascular ...as ...
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Morinda citrifolia (Noni) Fruit Juice Inhibits Endocannabinoid Degradation Enzymes
... both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) in a concentration-dependent manner, suggesting that it may help maintain anandamide and 2-arachidonoylglycerol ...
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Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
... Additional file 2: Figure S1. Sequence comparison of selected amidase signature family members. The sequences of Bacillus subtilis Glu-tRNAGln amidotransferase subunit A, Pseudomonas putida mandelamide hydrolase, ...
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Synthesis and Characterization of Urethane Modified Polyestreamide
... The fatty acids composition of the oil is given in Table-1. Phthalic acid, oxalic acid, acetic acid glacial, pyridine, methanol, carbon tetrachloride, sodium hydroxide, were used of analytical ...
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Tannase enzyme: The most promising biocatalyst for food processing industries
... Many Bacterial species have found to produce both the intracellular and extracellular tannase enzyme which can hydrolyze natural tannic acid very efficiently. It has been showed that strains of Bacillus pumilus, ...
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Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering
... In order to confirm that ELO use saturated sub- strates, we analyzed the elongation products of the strains ∆pox ∆fas and ∆pox ∆fas ∆elo1 grown with mC16:0 (Fig. 3a). Elongation of C16:0 will lead to C18:0, further ...
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Exploring the Role of Fatty Acid on Transcription Factors Regulating Fatty Acid Metabolism with Emphasis on Trans Fatty Acid
... of fatty acid in adipose tissue expressed as median and intraquartile range is given in Table ...Saturated fatty acid was the most abundant fatty acid with palmitic acid ...
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Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise
... CB1, FAAH, IL- 6 and TNF-a gene expression among the intervention groups (CR, CRM and CRV) at baseline and over-time changes were determined using one-way ...and FAAH gene expression between the diet alone ...
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FATTY ACID PROFILING IN DIPLOID (n = 12) AND TETRAPLOID CYTOTYPES (n = 24) OF PHYSALIS ANGULATA LINN FROM RAJASTHAN BY GAS CHROMATOGRAPHY
... the fatty acids obtained from the whole plant of diploid and tetraploid Physalis angulata ...The fatty acid analysis was carried out by gas chromatography-flame ionization detector ...the ...
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An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
... Various approaches are under investigation for the microbial synthesis of higher unbranched alcohols with respect to the origin of the saturated carbon chain and the formation of the terminal hydroxyl group. They are ...
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A STUDY ON PROXIMATE CONTENT, FATTY ACID AND AMINO ACID PROFILE OF SEA CUCUMBER STICHOPUS NOCTIVAGUS
... glutamic acid and glycine were the major component. The major essential amino acid was phenylalanine ...amino acid namely threonine was the major essential amino acid in Thelenota ananas, ...
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SYNTHESIS OF AMIDE-BASED SURFACTANTS FROM FATTY ACID METHYL ESTER: EFFECT OF SOLVENT RATIO AND STIRRING SPEED
... ester fatty acids used are obtained from the coconut oil trans-esterification ...free fatty acid should use a trans-esterification process using an alkaline catalyst ...
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