Fc gamma receptors
Fc gamma receptors: Glycobiology and therapeutic prospects
... antibody Fc region, which is critical for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, complement activation and phagocyto- ...by ...
11
The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer
... the Fc gamma receptors (Fc γ Rs) that trigger cell-mediated cytotoxic effector functions such as antibody dependent cellular cytotoxicity (ADCC) and phagocytosis ...for Fc γ R ...
10
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
... complement receptors and MHC class I proteins has spurred significant research interest in the role of immune molecules in CNS development and disease ...the Fc gamma receptors (FcγR) ...
23
In vivo glucocorticoid modulation of guinea pig splenic macrophage Fc gamma receptors
... affected Fc gamma R2, whereas dexamethasone inhibited the function of both guinea pig Fc gamma ...both receptors to bind IgG-sensitized ...
10
Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal
... Fc gamma receptors are important components in the binding and phagocytosis of IgG- sensitized ...these receptors have been limited by the fact that most hematopoietic cells express more than ...
7
Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells
... HIV-1 has evolved several mechanisms to evade the humoral response elicited against its envelope glycoproteins, including conformational masking of vulnerable epitopes, high sequence variability in the variable loops, ...
17
Defect in the membrane expression of high affinity 72 kD Fc gamma receptors on phagocytic cells in four healthy subjects
... different receptors for the Fc portion of IgG (FcR) have been characterized on human ...the Fc portion of mouse (m)-IgG2a and of monomeric human IgG, and they were unreactive with two anti-FcRI ...
9
Effect of gamma interferon on expression of Fc gamma receptors in monocytes of newborn infants and adults.
... identify Fc g RI and Fc g RII, respectively, and murine MAbs to irrelevant antigens (immunoglobulin G1 [IgG1], IG2a, and IG2b) served as isotype ...of Fc g R surface expression was accomplished by ...
7
Novel Fc gamma receptor I family gene products in human mononuclear cells
... second Fc gamma RI family gene, termed Fc gamma ...hFc gamma RIb1, encodes a surface molecule that is not recognized by Fc gamma RI specific monoclonal antibodies when ...
9
Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA
... Fc receptors for immunoglobulins are found on many cells and are important in host ...transfected Fc gamma RIIIA, present on macrophages and natural killer (NK) cells, into COS-1 cells to ...
8
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB Independent mechanisms for differences in human phagocyte function
... human Fc gamma receptors have been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma RIIA expressed on both PMN and monocytes and the NA1-NA2 polymorphism of the ...
9
A Panel of IgG1 b12 Variants with Selectively Diminished or Enhanced Affinity for Fcγ Receptors To Define the Role of Effector Functions in Protection against HIV
... human Fc ␥ Rs. To explore the Fc ␥ receptor bind- ing specificities of the b12 variants, we carried out ELISAs specific for Fc ␥ RI, H131-Fc ␥ RIIa, and F158-Fc ␥ ...to Fc ␥ RI ...
10
Lymphocytes with Immunoglobulin E Fc Receptors in Patients with Atopic Disorders
... bearing Fc receptors for immunoglobulin (Ig)E (Fc e ) and IgG (Fc g ), surface IgM (sIgM) and IgD (sIgD), and for T cells forming spontaneous rosettes with sheep erythrocytes ...of Fc e ...
8
Fc γ receptors and the complement system in T cell activation
... Activating Fc␥R are expressed by most effector cells of the immune system, particularly monocytes, macrophages, NK cells, mast cells, eosinophils, and neutrophils, while absent from lymphoid ...receptor Fc ...
88
Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis
... Over the last decade, advances have been made in un- derstanding the signal transduction pathways involved in the expression of proinflammatory molecules in AD. Phosphorylation and activation of specific intracellular ...
14
Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology?
... candidate receptors for HCV, namely the scavenger receptor class B type 1 (SR-B1) (139), dendritic cell-specific intracellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) (84, 126), and low-density ...
13
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
... Activin A regulates multiple biological functions such as hormonal homeostasis, inflammation, and bone homeo- stasis by stimulating osteoclastogenesis and inhibiting the formation of osteoblasts. Activin A is produced by ...
7
Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
... tions uncovered in the absence of liver resident macrophages (Kupffer cells) suggests that adenovirus-leukocyte interactions oc- cur independent of the traditional paradigm involving CAR and integrins (20). Recently, ...
10
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
... mAbs are among the most rapidly growing therapies for the treat- ment of cancer (1) and autoimmunity (2). Antibodies either fix complement or engage cells of the innate immune system to medi- ate target cell lysis. The ...
11
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
... MC Fc receptor– mediated (FcR-mediated) functions, including phagocytosis and Fc-mediated oxygen burst ...augments Fc-mediated function and promotes MC ...
11