Fc receptor for IgG
A major histocompatibility complex class I related Fc receptor for IgG on rat hepatocytes
... I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral ...this receptor beyond the neonatal period within the ...of IgG, we sought to determine whether the FcRn ...
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The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular Cytotoxicity In Vivo
... an IgG Fc receptor (Fc ␥ R) that blocks the Fc domain of antibody targeting the virus or infected ...HSV-1 Fc ␥ R in vivo have been hampered by difficulties in preparing an ...
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Improved tumor imaging and therapy via i v IgG–mediated time sequential modulation of neonatal Fc receptor
... of IgG, while allowing for enhanced tumor uptake of tumor-targeted IgG conjugates, also results in increased background activity and normal-tissue ...of IgG antibodies via pharmaco- logical ...
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Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
... luminal IgG/oral antigen (OVA) com- plexes into the intestinal mucosa, which activate antigen-specific immune responses systemically by transport of immune com- plexes to regional lymphatic tissues via ...cific ...
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Antigen targeting to myeloid specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice
... high-affinity Fc receptor for IgG (Fc g RI; CD64), which is exclusively present on myeloid ...of Fc g RI in antigen presenta- tion in vivo, we generated human Fc g RI transgenic ...
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Autoregulatory circuits in myeloma Tumor cell cytotoxicity mediated by soluble CD16
... with IgG-secreting ...the Fc receptor (sFcR, sCD16) that can bind to surface Ig on cultured human IgG-secreting myeloma cells and effect suppression of tumor cell growth and Ig ...
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An abnormality of the gene that encodes neutrophil Fc receptor III in a patient with systemic lupus erythematosus
... of Fc receptor III was limited to the patient's neutrophils (her natural killer cells reacted normally with anti-Fc receptor III antibodies), and was associated with abnormal recognition and ...
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Expression of neonatal Fc receptor in the eye
... of IgG after intravitreally injection is therefore not a naturally occurring situation and the biological mecha- nisms that affect the fate of intravitreally injected antibodies are not well ...
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Ecto 5′ Nucleotidase Activity in Human T Cell Subsets DECREASED NUMBERS OF ECTO 5′ NUCLEOTIDASE POSITIVE CELLS FROM BOTH OKT4+ AND OKT8+ CELLS IN PATIENTS WITH HYPOGAMMAGLOBULINEMIA
... We have previously shown 21 that Ty cells T cells with Fc receptors for IgG have only one-third the ecto-5'-NT activity of T$ cells T cells with Fc receptor for IgM; however, little is k[r] ...
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Measuring disease activity and predicting response to intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy
... Following the results of the Intravenous Immuno- globulin CIDP Efficacy (ICE) trial which established IVIg as an effective therapy for CIDP, the standard approach to initiating treatment has been to commence with an ...
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Antibody Recognition of Cell Surface-Associated NS1 Triggers Fc-γ Receptor-Mediated Phagocytosis and Clearance of West Nile Virus-Infected Cells
... and Fc- ␥ receptor III ⫺/⫺ but not Fc- ␥ receptor I ⫺/⫺ , III ⫺/⫺ , and IV ⫺/⫺ peritoneal macrophages ...an Fc- ␥ receptor-depen- dent mechanism ...given IgG subclass that ...
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Blocking Antibody Access to Neutralizing Domains on Glycoproteins Involved in Entry as a Novel Mechanism of Immune Evasion by Herpes Simplex Virus Type 1 Glycoproteins C and E
... with IgG Fc-mediated ...an IgG Fc receptor on the gC/gE mutant virus or to enhanced neutralization of the mutant virus by antibodies that target only gB, gD, or gH/gL, which are the ...
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Immunoregulation in Sjögren's Syndrome: INFLUENCE OF SERUM FACTORS ON T CELL SUBPOPULATIONS
... immunoglobulin (Ig)G (T G ) which was explained by a factor that blocked the expression of the IgG Fc receptor on T G cells. This blockage was reversible since the factor could be removed by ...
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Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae
... the Fc-fusion that potentially can be imparted to some antibody fragments is a decrease in their propensity to aggregate ...the Fc-fused antibodies increase from ap- proximately 12, 25, or 50 kDa (sdAb, ...
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Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.
... Studies of platelet activation by murine antiplatelet monoclonal antibodies via the platelet Fc-yRIIA receptor reveal three distinct patterns of behavior most likely corre-.. sponding to[r] ...
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CD226 opposes TIGIT to disrupt Tregs in melanoma
... Tregs, which express the transcription factor Foxp3, regulate innate and adaptive immune cells and main- tain self-tolerance (1). In preclinical cancer models, Tregs potentially abrogate T cell responses to tumors (2). ...
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Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens [see comment]
... In the present study the ability of pooled IgG to inhibit Staph-toxin elicited T cell activation was not mediated nonspecifically through the Fc region of IgG, as shown by the lack of in[r] ...
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Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
... IgG Fc glycosylation was analyzed in a subclass-specific way for 60 pediatric patients with a meningococcal infection admitted to the PICU, as well as for 46 age- and sex-matched healthy controls (Table 1; ...
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Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
... immobilized IgG to ligate the unblocked activating FcγRs, instead of relying on circulating immune complexes in serum that were diluted 100-fold in culture ...lized IgG, and we did not find a statistically ...
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Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity
... with Fc effector activity is crucial for optimal in vivo activity for protection against microbial pathogens and their toxins ...of IgG interaction with FcγRs is governed by the affinity of the Fc ...
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