FC-RECEPTORS
Fc receptors in immune thrombocytopenias: a target for immunomodulation?
... disease, Fc receptors (FcRs) form the interface between immune effector cells and their antibody-coated targets, and as such are attractive targets for immunomodulatory ...of Fc–FcR interactions ...
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Increase of lymphocytes with Fc receptors for IgE in patients with allergic rhinitis during the grass pollen season
... Peripheral blood lymphocytes from 10 nonallergic donors and 7 patients suffering from seasonal allergic rhinitis and receiving desensitization therapy were analyzed by rosette assays for Fc receptors for ...
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Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
... Ad vectors activate both the classical and alternative com- plement pathways (5). To determine the relative contributions of the two pathways in adenovirus-neutrophil interaction, ex- periments were performed using human ...
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Antibody mediated bacterial adhesion to cytomegalovirus induced Fc receptors Potential relationship to secondary infections complicating herpesvirus infections
... Cytomegalovirus (CMV) and other viruses within the herpes group have recently been shown to induce Fc receptors in infected monolayers. We have examined the possibility that such receptors might ...
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In the absence of other Fc receptors, Fc gamma RIIIA transmits a phagocytic signal that requires the cytoplasmic domain of its gamma subunit
... of Fc gamma RIII, Fc gamma RIIIA, is found on NK cells, cultured monocytes, and tissue macrophages in association with a dimer of an accessory subunit, either gamma or ...individual Fc ...
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Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41
... of Fc ␥ Rs in determining the fate of human immunode- ficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fc ␥ receptors (Fc ␥ RI, Fc ␥ RIIa, Fc ␥ ...
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Lymphocytes with Immunoglobulin E Fc Receptors in Patients with Atopic Disorders
... bearing Fc receptors for immunoglobulin (Ig)E (Fc e ) and IgG (Fc g ), surface IgM (sIgM) and IgD (sIgD), and for T cells forming spontaneous rosettes with sheep erythrocytes ...of Fc e ...
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Macrophage Fc receptors control infectivity and neutralization of canine distemper virus-antibody complexes.
... Titration endpoints were determined by syncytia formation that was induced by free virus 4 days after inoculation with virulent CDV in DLM cultures, 3 days after inoculation in Vero cell[r] ...
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Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
... MC Fc receptor– mediated (FcR-mediated) functions, including phagocytosis and Fc-mediated oxygen burst ...augments Fc-mediated function and promotes MC ...
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Ontogeny of Fc receptors and complement receptor (CR3) during human myeloid differentiation
... of Fc gamma Rlo appearance on bone marrow cells, leukocytes of patients with chronic myelogenous leukemia (CML), and HL-60 and U937 cells induced to differentiate with agents such as dimethyl ...
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Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
... mAbs are among the most rapidly growing therapies for the treat- ment of cancer (1) and autoimmunity (2). Antibodies either fix complement or engage cells of the innate immune system to medi- ate target cell lysis. The ...
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Function and heterogeneity of human Fc receptors for immunoglobulin G
... huFcRI HuFc7RI, found predominantly on monocytes and macrophages, binds monomeric human IgG with high avidity Ka = 1-3 X 108 M-' and with a subclass specificity of IgGl > IgG3 > IgG4 > I[r] ...
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Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes
... Although recent studies suggest that interferons can increase the number of IgG Fc receptor (FcR gamma) sites on mouse macrophages, direct assessment of similar effects on human mononuclear phagocytes is lacking. ...
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Analysis of Defined Combinations of Monoclonal Antibodies in Anthrax Toxin Neutralization Assays and Their Synergistic Action
... blocking Fc ␥ receptors of the cells renders the MAbs partially neu- tralizing ...that Fc ␥ receptors I and IV may play a role in the decrease in neutralization seen at the higher MAb ...
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A Panel of IgG1 b12 Variants with Selectively Diminished or Enhanced Affinity for Fcγ Receptors To Define the Role of Effector Functions in Protection against HIV
... the Fc fragment of the broadly neutralizing antibody IgG1 b12 and cellular Fc ␥ receptors (Fc ␥ Rs) plays an important role in protection against SHIV infection in rhesus ...this ...
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Fc γ receptors and the complement system in T cell activation
... IgG Fc Receptors (Fc ␥ R) facilitate the efficient uptake of IC by dendritic ...is Fc ␥ R-dependent. To study the role of different Fc ␥ R and complement in MHC class I Ag presentation ...
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The Binding of Human Immunoglobulin G1 Monomer and Small, Covalently Cross Linked Polymers of Immunoglobulin G1 to Human Peripheral Blood Monocytes and Polymorphonuclear Leukocytes
... Covalently cross-linked dimers and oligomers composed of 2-4 subunits of monoclonal human IgG1 were prepared by incubation of purified monomeric IgG1 with glutaraldehyde followed by gelfiltration chromatography. ...
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JAM-A-Independent, Antibody-Mediated Uptake of Reovirus into Cells Leads to Apoptosis
... the Fc receptor contributes to apoptosis induction, we tested whether incubation of reovirus with irrelevant anti-Myc MAb 9E10 was capable of inducing apoptosis ...of Fc receptor cross-linking due to ...
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Fc gamma receptors: Glycobiology and therapeutic prospects
... antibody Fc region, which is critical for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, complement activation and phagocyto- ...by ...
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Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis
... Fc receptors (FcRs) bind the constant domain (Fc) of im- munoglobulins (Ig). Specific FcRs exist for each isotype class and sub-class of Ig; for example, IgA is the ligand for FcαR, IgD for FcδR, IgM ...
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