Fcγ receptor
Helicobacter pylori eradication shifts monocyte Fcγ receptor balance toward inhibitory FcγRIIB in immune thrombocytopenic purpura patients
... Immune thrombocytopenia purpura (ITP) is a bleeding disorder in which platelet-specific autoantibodies cause a loss of platelets. In a subset of patients with ITP and infected with Helicobacter pylori, the number of ...
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Monocyte surface expression of Fcγ receptor RI (CD64), a biomarker reflecting type I interferon levels in systemic lupus erythematosus
... (Fcγ receptor I) expression on monocytes can be used to assess IFN-I levels rapidly and reliably in clini- cal samples and may be well suited to monitoring disease activity and response to ...
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Modulation of tumor growth by inhibitory Fcγ receptor expressed by human melanoma cells
... The efficacy of anti-tumor IgG reflects the balance between opposing signals mediated by activating and inhibitory Fcγ receptors (FcγRs) expressed by effector cells. Here, we show that human malignant melanoma ...
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Developing recombinant HPA 1a–specific antibodies with abrogated Fcγ receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia
... Fetomaternal alloimmune thrombocytopenia (FMAIT) is caused by maternal generation of antibodies spe- cific for paternal platelet antigens and can lead to fetal intracranial hemorrhage. A SNP in the gene encod- ing ...
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Fcγ receptor mediated influx of S100A8/A9 producing neutrophils as inducer of bone erosion during antigen induced arthritis
... Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that primarily affects the joints [1]. Along with inflammation, excessive bone erosion is one of the central hallmarks of this disease [2, 3]. Next ...
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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
... different receptor properties ...toll-like receptor 9 and FcγRIIIA polymorphisms ...anchored receptor, exclusively expressed on neutrophils with three characterized allo- types ...
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Divergent Requirement of Fc-Fcγ Receptor Interactions for In Vivo Protection against Influenza Viruses by Two Pan-H5 Hemagglutinin Antibodies
... In the present study, we demonstrated that a single injection of 1 or 2 mg/kg (minimum protective doses) of 65C6/IgG2a, 65C6/D265A, or 100F4/IgG2a, but not 100F4/D265A, completely or almost completely protected mice from ...
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Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B
... The Fc γ receptors (Fc γ Rs), which bind these IgG autoantibod- ies and IgG-containing immune complexes, have been shown to play important roles in the initiation and regulation of many immunological and inflammatory ...
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Enhancement of Splenic-Macrophage Fcγ Receptor Expression by Treatment with Estrogens
... macrophage receptor Fc␥R1- Fc␥R2 in our experiments appears to be more responsive to such estrogen-induced modulatory signals than the other mac- rophage Fc␥R, ...
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Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B
... The FcγRs play important roles in the initiation and propaga- tion of many different immunological and inflammatory proc- esses. Consequently, they may act as susceptibility factors for RA through a variety of ...
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Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B
... The Fcγ receptors (FcγRs), which bind these IgG autoantibod- ies and IgG-containing immune complexes, have been shown to play important roles in the initiation and regulation of many immunological and inflammatory ...
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Genetic Variants in Toll-Like Receptor 2 (TLR2), TLR4, TLR9, and FCγ Receptor II Are Associated with Antibody Response to Quadrivalent Meningococcal Conjugate Vaccine in HIV-Infected Youth
... Fc receptor (FC ␥ RII)-A484T, interleukin-10 (IL-10)-A1082G, -C819T, and -C627A, IL-4-C589T, mannose binding lectin-2 (MBL2)-A/O, -H/L, -P/Q, and -X/Y, toll-like receptor 2 (TLR2)-G2408A, TLR4-A12874G and ...
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The involvement of PKD in Fcγ receptor activation of the NADPH oxidase in human neutrophils
... on the membrane upon Fey receptor dimérisation. It was shown that these vesicles contained rhodamine-labelled S. aureus, which were encircled by PKD. Furthermore, using rhodamine-conjugated phalloidin we showed ...
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Discrepancy in Dengue Virus Neutralizing Antibody Titers between Plaque Reduction Neutralizing Tests with Fcγ Receptor (FcγR)-Negative and FcγR-Expressing BHK-21 Cells
... Dengue virus (DENV), a member of the family Flaviviridae, represents a major health problem in tropical and subtropical regions of the world. There are four serotypes, dengue virus types 1 to 4 (DENV-1 to DENV-4). DENV ...
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Poorly Neutralizing Cross-Reactive Antibodies against the Fusion Loop of West Nile Virus Envelope Protein Protect In Vivo via Fcγ Receptor and Complement-Dependent Effector Mechanisms
... Here, we show that while passive transfer of poorly neutralizing monoclonal antibodies MAb and polyclonal antibodies against the DII-FL epitope protect against lethal WNV infection in wi[r] ...
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A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti glucose 6 phosphate isomerase antibodies
... Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/B×N mice, although some groups have reported that few healthy humans retain these antibodies. The expression of ...
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Fcγ Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages
... receptor CCR5 or CXCR4 (2), suggesting that Fc␥R-mediated HIV-1 suppression in MDM involves a postentry level of re- striction. HIV-1 entry into macrophages can occur either by a classical fusion process at the ...
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Early Steps of Clathrin-Mediated Endocytosis Involved in Phagosomal Escape of Fcγ Receptor-Targeted Adenovirus
... integrin coreceptors. In the absence of CAR, they can be directed to the Fc ␥ receptor 1 of hematopoietic cells by an adaptor comprising the extracellular CAR domain and the Fc portion of a human immunoglobulin G ...
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Identification and Expression of Human Cytomegalovirus Transcription Units Coding for Two Distinct Fcγ Receptor Homologs
... . Identical residues are shaded in dark grey; residues showing similarity, defined as acidic (D or E), basic (H, K, or R), hydrophobic (A, F, I, L, M, P, V, or W) or polar (C, G, N, Q, S, T, or Y) are shaded in light ...
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A Study of Differential Glycosylation of IgG on Fcγ Receptor Mediated Neutrophil Recruitment Model of SLE Nephritis
... classical Fcγ Receptors (FcγRs): FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, and FcγRIIIB and a single receptors can possess high and low affinity interactions, where the low affinity characteristic can bind IgG ...
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