Fetal hemoglobin
BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations
... from fetal hemoglobin (HbF) to adult hemoglobin (HbA) expression that occurs during the months following birth is of considerable therapeutic interest, since elevated HbF ame- liorates the clinical ...
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The role of epigenetics in the induction of fetal hemoglobin: a combination therapy approach.
... Material and Methods:We used thalidomide and sodium butyrate for increasing the level of fetal hemoglobin in erythroid progenitors. Briefly, after isolation of CD133+ stem cells from umbilical cord blood ...
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Induction of human fetal hemoglobin expression by adenosine 2’,3’ dialdehyde
... reactivates fetal hemoglobin expression ...of fetal globin by Adox may be through a mechanism involving inhibition of PRMT5 in both K562 and human bone marrow erythroid progenitor ...reactivating ...
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Balanced Globin Chain Synthesis in Hereditary Persistence of Fetal Hemoglobin
... In two black families with the hereditary persistence of fetal hemoglobin (HPFH) gene there are eight A-F heterozygotes and two double heterozygotes for sickle cell trait and HPFH. These patients are ...
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Production of Erythrocytes that Contain Fetal Hemoglobin in Anemia: TRANSIENT IN VIVO CHANGES
... Serial microscopic immunodiffusion assays of F cells, i.e., erythrocytes that contain fetal hemoglobin HbF, in four individuals recovering from anemia demonstrate initial increases in th[r] ...
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Nature of fetal hemoglobin in the Greek type of hereditary persistence of fetal hemoglobin with and without concurrent β thalassemia
... The fetal hemoglobin in the affected members of three Greek families with the hereditary persistence of fetal hemoglobin has only g-chains of the type with alanine in position ...their ...
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Aggregation of adult and fetal hemoglobin by ingested nitrate anions
... terminal residue of the β -subunit in HbA is Val, which has a pKa of 6.6, but the corresponding Gly on the γ -subunit of HbF has a much higher pKa of 8.1 (35). Because protonated amino group of Gly in HbF tends more bind ...
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Further studies of the frequency and significance of the Tgamma chain of human fetal hemoglobin
... human fetal hemoglobin that is synthesized in increased amounts in persons with the hereditary persistence of fetal ...human fetal globulin from determinants in cis and in trans, the ...
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Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
... 2.0%. Fetal hemoglobin increased from ...II. Hemoglobin of patient I increased from ...the fetal hemoglobin of patient I t ...total hemoglobin at ...
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Role of XmnIgG Polymorphism in Hydroxyurea Treatment and Fetal Hemoglobin Level at Isfahanian Intermediate β-Thalassemia Patients
... γ-globin gene expression and the severity of clinical symptoms of β-thalassemia. Methods: In the present study, 51 β- thalassemia intermediate patients were studied. Xmn1γ G polymorphism genotype was determined using ...
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Cellular Mechanisms for Increased Fetal Hemoglobin Production in Culture: EVIDENCE FOR CONTINUOUS COMMITMENT TO FETAL HEMOGLOBIN PRODUCTION DURING BURST FORMATION
... containing fetal hemoglobin (FNRBC) and the mean picograms of fetal or adult hemoglobin per nucleated erythrocyte (picograms HbF/NRBC, picograms HbA/NRBC) were assayed in 14-d-old colonies ...
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FACTORS INFLUENCING RELATIVE RATES OF SYNTHESIS OF ADULT AND FETAL HEMOGLOBIN IN VITRO
... Effect of hypoxia on the relative rates of synthesis of adult and fetal hemoglobin by cord blood reticulocytes in vitro Per cent increase.. As hemet: 2nd crystallization 3rd crystallizat[r] ...
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Elevated Levels of Fetal Hemoglobin Synthesis in Infants With Bronchopulmonary Dysplasia
... levels of fetal hemoglobin (HbF) synthesis are elevated in infants with bronchopulmonary dysplasia (BPD) when compared with the levels of HbF synthesis found in normal control infants.. [r] ...
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Chronic Myelogenous Leukemia in an Infant: Serial Cytogenetic and Fetal Hemoglobin Studies
... The persistently normal levels of fetal hemoglobin in the young infant reported in this article confirm the previous. observations in the adult type of CML[r] ...
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Mutant Fetal Hemoglobin Causing Cyanosis in a Newborn
... have a mutant -y-globin chain, leading to a functionally abnormal fetal hemoglobin.. A single amino acid substi- tution was found in a site consistent with known adult M hemoglobins.[r] ...
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Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia
... Abstract: The natural history of severe hemoglobinopathies like sickle cell disease (SCD) is rather variable, depending on the circumstances, but the main influence on such variability is the level of fetal ...
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Relative Rates of Fetal Hemoglobin and Adult Hemoglobin Synthesis in Cord Blood of Infants of Insulin-Dependent Diabetic Mothers
... Relative Rates of Fetal Hemoglobin and Adult Hemoglobin Synthesis in Cord Blood of. http://pediatrics.aappublications.org/content/75/6/1143[r] ...
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Control of the Simian Fetal Hemoglobin Switch at the Progenitor Cell Level
... This investigation was designed to define the cellular level at which the gamma to beta globin switch is established in the developing simian fetus in order to determine whether the switch is controlled by environmental ...
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Effect of fetal hemoglobin on microvascular regulation in sickle transgenic knockout mice
... The low hematocrit level in BERK mice (28.7% ± 4.0% vs. 48% ± 1.0% for C57BL mice) was associated with high reticulo- cyte counts (39.5% ± 4.3% vs. 1.4% ± 0.4% for C57BL) and increased plasma hemo- globin levels ...
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Fetal hemoglobin accumulation in vitro Effect of adherent mononuclear cells
... of fetal and adult hemoglobins (Hb F and Hb A) was measured by radioligand ...mean hemoglobin content, or the asynchrony of the production of the two ...
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