Fibrin(ogen)olysis
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification
... Hypo- fibrinolysis in the absence of plasmin(ogen) did not affect devel- opment of chondroid soft-tissue callus or expression of VEGF-A in hypertrophic chondrocytes, but instead resulted in persistent fibrin ...
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Time course of thrombosis and fibrinolysis during total hip surgery
... In this study, markers of thrombosis and fibrinolysis were measured during the different phases of THA. We found that intravascular thrombin formation originated at the start of surgery, and that activation was at ...
5
Regulation of the Activation and Function of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
... Background: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a human plasma zymogen that provides a molecular connection between coagulation and fibrinolysis. TAFI is activated through proteolytic ...
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Significance of Cross Linking of α2 Plasmin Inhibitor to Fibrin in Inhibition of Fibrinolysis and in Hemostasis
... underwent fibrinolysis at similar rates, regardless of the concentrations of a 2 PI in the ...of fibrinolysis was also inversely proportional to the amount of a 2 PI cross-linked to ...spontaneous ...
8
Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... leading to extravascular fibrin deposition, using two well- established mouse models of RA: AIA and CIA. The kinetics of gene expression was first analyzed in mice with AIA, because this model allows for an accurate, ...
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Bleeding Complications after Basilar Artery Fibrinolysis with Tissue Plasminogen Activator
... before fibrinolysis had no stent placed, but had no residual stenosis, and did not bleed ...during fibrinolysis for basilar artery thrombosis and successful recanali- zation further predispose patients to ...
5
Thrombin activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life
... In summary, we have generated and characterized TAFI-deficient mice. The current study demonstrated that TAFI deficiency is compatible with murine life. TAFI-deficient mice did not exhibit any abnormal phe- notypes ...
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Warfarin and fibrinolysis - a challenging combination: an observational cohort study
... Pre-hospital fibrinolysis is an effective alternative in the treatment of acute ST-segment elevation myocardial infarction ...to fibrinolysis is related to reduced mortal- ity ...
6
Reduced thrombin formation and excessive fibrinolysis are associated with bleeding complications in patients with dengue fever: a case–control study comparing dengue fever patients with and without bleeding manifestations
... to show some differences in coagulation and fibrinolysis markers, particularly the profound differences in platelet counts observed between bleeding and non-bleeding patients. On the other hand, the careful ...
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Regulation of expression of CPB2, the gene encoding human thrombin activatable fibrinolysis inhibitor (TAFI): the role for post-transcriptional regulation
... and fibrinolysis, preventing excessive blood loss following vascular injury while maintaining the fluidity of the blood at sites remote from the ...the fibrinolysis cascade is to convert insoluble fibrin to ...
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Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
... attenuates fibrinolysis and hence promotes clot ...attenuates fibrinolysis through a threshold- dependent mechanism ...threshold, fibrinolysis is successfully ...accelerating fibrinolysis. ...
244
Thrombin mediated activation of factor XI results in a thrombin activatable fibrinolysis inhibitor dependent inhibition of fibrinolysis
... Recently, it has been shown that Factor XI can be activated by thrombin, and that Factor XIa significantly contributes to the generation of thrombin via the intrinsic pathway after the clot has been formed. This ...
6
Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury
... and fibrinolysis, and can trigger an inflammatory response ...and fibrinolysis independent of injurious ventila- tion, we studied patients at two hospitals that routinely use a low-tidal-volume ...
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Enhancement of fibrinolysis in vitro by ultrasound
... The effect of ultrasound on the rate of fibrinolysis has been investigated using an in vitro system. Plasma or blood clots containing a trace label of 125I fibrin were suspended in plasma containing plasminogen ...
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Clinical review: Intrapericardial fibrinolysis in management of purulent pericarditis
... Th ree complications of fi brinolysis can theoretically occur. Even if allergy is a well-known side eff ect of fi brinolysis after repeated instillation of SK, treatment with UK or tPA greatly reduces this risk [50]. Th e ...
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The Case for a Phase III Trial of Cerebral Intraarterial Fibrinolysis
... Among a number of issues raised in their paper about the efficacy of directed intraarterial delivery of a fibrinolytic agent, several demand closer scrutiny: a Does cerebral arterial rec[r] ...
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Intrathecal Fibrinolysis with Streptokinase in Tuberculous Meningitis
... It has been shown that the customary dose of streptokinase used for intrathecal treatment 100 Christensen Units will usually be insufficient to produce free fibrinolytic enzyme.. The var[r] ...
9
Local intraarterial fibrinolysis in the carotid territory
... B, Right carotid angiogram, anteroposterior projection, early arterial phase, shows occlusion of internal carotid at its bifurcation large straight arrow, occlusion of origin of middle a[r] ...
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Spontaneous fibrinolysis in pulmonary embolism
... Two patients, who both had 61% occlusion of their pulmonary vascular bed, had fibrin split products detectable in their serum for only 2 and 3 days yet had complete resolution of their f[r] ...
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Platelets, coagulation and fibrinolysis in breast cancer progression
... Platelet roles in breast cancer progression, including increased survival of disseminated cancer cells within the circulation, tumor cell adhesion to the endothelium, extravasation into [r] ...
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