Fibroblast growth factor (FGF2)
Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells
... (CNS). Fibroblast growth factor-2 (FGF2) belongs to the FGF superfamily and functions as a potential oncoprotein in ...GBM. FGF2 has low molecular weight (18K) and high molecular weight ...
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Action of fibroblast growth factor 2 on the intervertebral disc
... Fibroblast growth factor 2 antagonizes BMP7-mediated stimula- tion of proteoglycan accumulation in the cell-associated ...ng/ml fibroblast growth factor 2 (FGF2), 100 ...
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... Fibroblast growth factor (FGF) signaling is essential for normal and cancer ...affinities. FGF2 is the prototype member of the FGF family and interacts with its receptor to mediate receptor ...
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The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model
... transforming growth factor-β1 (TGF-β1) activity which in turn caused increased synthesis of extracellular matrix (ECM) proteins (collagen and GAGs) as seen in heart valves of carcinoid syndrome patients [4, ...
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Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Hemodialysis Patients
... risk factor for cardiovascular death in hemodialysis (HD) ...that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in HD ...
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Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... Sections were deparaffinized with xylene and rehy- drated with ethanol. Antigen retrieval was performed by placing the specimen in 0.01 M citrate buffer at pH 6.0 and exposed to microwave heating of 10 minutes at 250 W ...
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Fibroblast growth factor receptors and skeletogenesis
... The sequential formation of the active signalling complex is still controversial (Ornitz, 2000). The binding of FGFs to HSPGs was thought to be responsible for FGFR dimérisation and activation (Spivak-Kroizman et al., ...
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Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants
... of FGF2. Unlike VEGFA expression, excessive FGF2 does not give rise to a reverse effect but cannot fully exert its ...main factor regulating ITGB expression after Day ...
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Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus
... I), fibroblast growth factor (FGF2) solution (positive control; group II) and hyperosmotic dextran solutions (10 KD and 40 KD as experimental solutions: groups III and IV) for 12 days at ...
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Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells
... cells; FGF2: Fibroblast growth factor 2; FGFR: Fibroblast growth factor receptor; FPKM: Fragments per kilobase of transcript per million fragments mapped; GO: Gene ...
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Malondialdehyde mediates oxidized LDL-induced coronary toxicity through the Akt-FGF2 pathway via DNA methylation
... prosurvival fibroblast growth factor 2 (FGF2) were significantly reduced (P < ...the FGF2 promoter that was responsible for the transcriptional repression of FGF2 by ...of ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... the cortex. Synaptogenesis is the formation of synapses between neurons and occurs as an integration of signaling, recognition, adhesion and protein targeting. This process begins with axonal guidance to the correct ...
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Effects of platelet derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat storing cells
... platelet-derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth factor (TGF)-alpha and TGF-beta, and basic fibroblast growth factor ...
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Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model
... basic Fibroblast Growth Factor (bFGF) (Peprotech), 20 ng/ml Epidermal Growth Factor (EGF) (Peprotech), 5 μg/ml Insu- lin (Sigma), 2% B27 supplements (Invitrogen) and 4% base- ment ...
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Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors
... epidermal growth factor; FGF: fibroblast growth factor; VEGF: vascular endothelial growth factor; PDGF: platelet‑derived growth factor; RCC: renal cell ...
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The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
... BRG1-associated factor 60; Cdc42: cell division control protein 42; CDK: cyclin-dependent kinase; Cdo: cell adhesion molecule-related/downregulated by oncogenes; CIP/KIP: cyclin- dependent kinase-interacting ...
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Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH
... PTH: fibroblast growth factor, epidermal growth factor, and insulin stimulated chondrocyte proliferation irrespective of cartilage ...
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Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
... GFs: growth factors; GF: growth factor; NTFs: neurotrophic factors; bFGF: basic fibroblast growth factor; NGF: nerve growth factor; DPN: diabetic peripheral ...
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Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice
... basic fibroblast growth factor; bFGFR: basic fibroblast growth factor receptor; BMSC: bone marrow-derived mesenchymal stem cell; BSA: bovine serum albumin; CCK-8: Cell Counting ...
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The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
... endothelial growth factor (VEGF), a dimeric 46-kDa gly- coprotein, is an endothelial cell-specific, multifunctional ...Platelet-derived growth factor (PDGF) has angiogenic effects and stimu- ...
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