fibroblast growth factor receptor
Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types ...
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Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis
... The fibroblast growth factor receptor 2 (FGFR2) gene is perhaps the most extensively studied gene that is mutated in various craniosynostotic syndromes including Crouzon, Apert, Pfeiffer, ...
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The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... c-MET, fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their clinical significance in clinical therapy ...
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Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer
... transcription factor brachyury plays an important role in lung cancer development and ...that fibroblast growth factor receptor 1/mitogen-activated protein kinase (FGFR1/MAPK) signaling ...
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Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3
... Fibroblast growth factor receptor 3 (FGFR3) plays an important regulatory role in tumor cell proliferation and drug resistance. FGFR3 is often constitutively active in many tumors. To deliver ...
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Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival
... cell growth, we identified fibroblast growth factor receptor 4 (FGFR4) as a potential mediator of cell ...secrete fibroblast growth factor 19 (FGF19), a canonical ...
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Original Article Fibroblast growth factor receptor 4 is not an independent prognostic biomarker in patients with lung adenocarcinoma
... Received March 2, 2016; Accepted August 15, 2016; Epub November 15, 2016; Published November 30, 2016 Abstract: The aim of this study was to evaluate the clinical significance of fibroblast growth ...
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Original Article Altered expression of fibroblast growth factor receptor 2 isoform IIIc: relevance to endometrioid adenocarcinoma carcinogenesis and histological differentiation
... Abstract: Fibroblast growth factor receptor 2 (FGFR2) is activated in many cancers and considered as a potential therapeutic molecular target including for endometrial endometrioid carcinoma ...
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The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor
... for the DNA synthesis assay up to the addition of growth factors. At the times indicated, Rama 27 cells were washed twice with ice-cold Tris-buffered saline (TBS) contained 100 μM sodium vanadate and then lysed in ...
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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
... effect is specific to FGFR-expressing cells, we employed a model system of U2OS and U2OS FGFR1 cells (stably transfected with the FGFR1) in which otherwise identical osteosarcoma cells lacking and expressing FGFRs can be ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... the receptor during transport. As a receptor involved in FGF signaling, Flg is found in the membrane fraction, as it is a membrane-associated protein (Meyers et ...
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The structure and function of vertebrate fibroblast growth factor receptor 1
... to respond to signals in their environment must be able to be transmit these signals across the cell membrane and initiate signal transduction events, whereas other cells in the local environment must remain ...
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2 induced catabolic activities in human articular chondrocytes
... Progressive damage to articular cartilage is a hallmark of OA, and a principal cause of tissue break-down is the destruction rather than formation of the cartilage extra- cellular matrix by chondrocytes. Thus, metabolic ...
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The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation
... reports showed that FGFR2 IIIb functions as a tumor suppressor. For example, ectopic expression of FGFR2 IIIb in human prostate tumor PC-3 cell lines (64) or salivary adenocarcinoma cells (65) resulted in reduced cell ...
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Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer
... To elucidate the underlying EGFR-TKI resistance mech- anisms in PC-9/PEM, we assessed Akt and Erk signaling downstream of EGFR in both PC-9 and PC-9/PEM cells after treatment with erlotinib or DMSO. As shown in Fig. 2c, ...
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Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B ...
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Absence of Poly(ADP-ribose) Polymerase-1 Alters Nuclear Factor-κB Activation and Gene Expression of Apoptosis Regulators after Reperfusion Injury
... other growth factors and cell death regulators that participate in tissue regeneration and wound repair (such as amphiregulin, fibroblast growth factor receptor 3, and early ...
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Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice
... basic fibroblast growth factor; bFGFR: basic fibroblast growth factor receptor; BMSC: bone marrow-derived mesenchymal stem cell; BSA: bovine serum albumin; CCK-8: Cell ...
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Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review
... multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1–3, fibroblast growth factor receptor (FGFR) 1–4, ...
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STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
... Epidermal growth factor receptor; ER: Estrogen receptor; EZH2: Enhancer of zeste homolog 2; FAK: Focal adhesion kinase; FGFR: Fibroblast growth factor receptor; ...
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