Fibroblast growth factor receptor 1
Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer
... transcription factor brachyury plays an important role in lung cancer development and ...that fibroblast growth factor receptor 1/mitogen-activated protein kinase (FGFR1/MAPK) ...
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins
... unliganded receptor dimers [47 – ...of receptor monomers and high molecular weight band of molecular weight over 300 kDa probably reflecting recep- tor dimers and/or complexes with partner proteins ...
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2 induced catabolic activities in human articular chondrocytes
... Progressive damage to articular cartilage is a hallmark of OA, and a principal cause of tissue break-down is the destruction rather than formation of the cartilage extra- cellular matrix by chondrocytes. Thus, metabolic ...
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Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies
... A 32-year-old Radiologist presented in March 2019 with asymptomatic generalized lymphadenopathy, erythematous painful skin rash over both lower limbs with waxing and waning pattern for three months and weight loss. He ...
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The structure and function of vertebrate fibroblast growth factor receptor 1
... FGF receptor genes it is likely that the human FGFR1 gene is comprised of 19 exons ...(Fig. 1; Johnson et ...secreted receptor isoforms lacking the kinase domain have been shown to result from ...
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Histamine up-regulates fibroblast growth factor receptor 1 and increases FOXP2 neurons in cultured neural precursors by histamine type 1 receptor activation: conceivable role of histamine in neurogenesis during cortical development in vivo
... lated with neuronal differentiation in telencephalic neural precursors [43]. In addition, other factors might contribute to HA-induced neurogenesis. Our recent re- sults [17] suggest that the HA neurogenic effect is at ...
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Fibroblast Growth Factor Receptor 1 Overexpression Is Associated with Poor Survival in Patients with Resected Muscle Invasive Urothelial Carcinoma
... epidermal growth factor-2 receptors (HER2) play crucial role in signal transduction pathways regarding cell pro- liferation, survival, angiogenesis, and ...
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Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma
... A total of 526 Korean patients who underwent curative esophagectomy were analyzed. The clinical characteristics of the enrolled patients are presented in Table 1. There were 489 male and 37 female with a median ...
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Targeted disruption of fibroblast growth factor receptor 1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies
... semi-thin sections of fixed EBs. We first tested if the absence of FGFR-1 interferes, under our experimental conditions, with the initial steps in the process of EB formation. In agreement with previously ...
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Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review
... include receptor tyrosine kinases vascular endothelial growth factor receptor 1–3, endothelial growth factor receptor (EGFR), fibroblast growth ...
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THE ROLE OF GENE-GENE INTERACTIONS IN THE FORMATION OF THE GENITAL ENDOMETRIOSISIrina V. Ponomarenko, Vladimir F. Kulikovskiy, Evgeniy N. Krikun, Alexander A. Dolzhikov, Olga Yu. Bushueva and Alexey V. PolonikovDOWNLOAD/VIEW
... Fibroblast growth factor receptor 1 (FGFR1) encoded by this 174 gene is a member of the FGFR family, where amino acid sequence is highly conserved between members and throughout ...
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Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study
... protein 1; ECP: eosinophil cationic protein; EGF: epidermal growth factor; EN-RAGE: protein S100-A12; ESM-1: endothe- lial cell-specific molecule 1; FABP4: fatty acid-binding protein, ...
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The fibroblast growth factor receptor is not required for herpes simplex virus type 1 infection.
... In this case, we found that a soluble FGF receptor fragment was able to bind bFGF directly and inhibited bFGF binding and receptor activation; however, the soluble receptor did not inhib[r] ...
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Expanding the mutational spectrum of monogenic hypogonadotropic hypogonadism: novel mutations in ANOS1 and FGFR1 genes
... type 1 fibroblast growth factor (FGF) ...The receptor contains an extracellular domain that has three immunoglobulin-like domains (IgI, IgII and IgIII) responsible for the receptors ...
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... FGFRs 1-3 can undergo alternative splicing during gene expression, and the IgIII domain is composed of an invariant IgIIIa exon alternatively spliced to IgIIIb or ...FGFRs 1-4 contains a juxtamembrane split ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... of 1% DNAse (until the clump of tissue dissociated) was added; the tube was inverted 2-3 times to facilitate DNA ...Approximately 1 000 000 cells were plated onto 35 mm confocal dishes (MatTek ...
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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... of fibroblast growth factors (FGFs) [1, ...bound receptor, FGFR2 contains an extracellular region, which is made up of signal peptides (SP), three immunoglobulin domains (D1, D2, and D3) and ...
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The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor
... for the DNA synthesis assay up to the addition of growth factors. At the times indicated, Rama 27 cells were washed twice with ice-cold Tris-buffered saline (TBS) contained 100 μM sodium vanadate and then lysed in ...
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ER and PR signaling nodes during mammary gland development
... its receptor (receptor activator of NF-κB) in the mammary epithelium is sufficient to induce side branching in virgin mammary Figure ...estrogen receptor (ER) alpha/ progesterone receptor ...
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Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival
... significant growth inhibition (Z-score < –2) in MDA-MB-468 ...that 1) at least two independent shRNAs targeting a specific gene exhibit a Z-score of less than -2, and 2) the P-value of Redundant siRNA ...
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