Fibroblast growth factor receptor 2
The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... and fibroblast growth factor receptor 2 (FGFR2) play key roles in tumor proliferation, invasion, angiogenesis, and metasta- sis, and they are considered potential therapeutic targets or ...
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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... Fibroblast growth factor receptor 2 (FGFR2) belongs to a family of four typical membrane-bound receptor tyrosine kinases (RTKs) ...FGF receptor, FGFR5, has been ...
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Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
... We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that ...
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Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer
... Fibroblast growth factor receptor 2 (FGFR2)-targeted therapy has attracted considerable attention as novel anticancer agents in gastric cancer ...several receptor tyrosine kinase ...
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Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis
... The fibroblast growth factor receptor 2 (FGFR2) gene is perhaps the most extensively studied gene that is mutated in various craniosynostotic syndromes including Crouzon, Apert, ...
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Co localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development
... During our studies of early development we observed that both NCAM and FGFR2 are expressed on mRNA level (Table 1) and this observation lead us to investigate whether the proteins were present and if so where the ...
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Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM 52PE
... the receptor, alternative splicing of exon III results in the synthesis of either the IIIb or IIIc versions of FGFR2, which differ in their ligand ...KGF receptor, has been shown to be a high-affinity ...
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Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome
... (Fig. 2 C, left panel), and (b) many relatively flat cells with a strong fluorescence signal mainly confined to a Figure ...M 2 -III-6 to detect cMOAT, showing ...
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The role of fibroblast growth factor receptor 2 (FGFR2) in differentiation of bovine spermatogonial stem cells (SSCs)
... Fibroblast growth factor receptors (FGFRs) are evolutionarily conserved trans-membrane proteins that are composed of an extracellular ligand-binding domain, a transmembrane region and a cytoplasmic ...
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The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation
... determine if loss of Y770 causes decreased tyrosine phosphorylation of PLCγ, Rat-1 cells stably-expressing a series of FGFR2 IIIb C1 mutants (Y770F, Y770F/L773A, Y770A/L773A and L773A), as well as the WT C1, C2 and C3 ...
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Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies
... A 32-year-old Radiologist presented in March 2019 with asymptomatic generalized lymphadenopathy, erythematous painful skin rash over both lower limbs with waxing and waning pattern for three months and weight loss. He ...
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Modulation of fibroblast growth factor 2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin mimicking polyanionic compound
... Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors. To mod- ulate the ...
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Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers
... Using the spontaneously metastatic 4T1 model in combination with a stable E-cad-luciferase reporter sys- tem, we quantified the dynamic regulation of E-cad ex- pression during the various steps of the metastatic cascade ...
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins
... unliganded receptor dimers [47 – ...of receptor monomers and high molecular weight band of molecular weight over 300 kDa probably reflecting recep- tor dimers and/or complexes with partner proteins ...
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Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3
... RNA isolation, cDNA synthesis and real‑time RT‑PCR Total RNA of RT112 and T24 cells was extracted using the RNeasy Mini Kit (QIAGEN), and reversely tran- scribed into cDNA using reverse transcription (RT) PCR kit (The ...
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2 induced catabolic activities in human articular chondrocytes
... immunoblotting, and quantitative real-time PCR (qPCR). The distinctive roles of FGFR1 and FGFR3 after stimulation with FGF-2 were evaluated using either pharmacological inhibitors or FGFR small interfering RNA ...
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Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes
... sample buffer (ALO, All Prep ™ kit, Qiagen, German- town, MD), incubated at 90°C for 4 min, separated on a 10% SDS-PAGE gel, and transferred to a PVDF mem- brane (Amersham, GE Healthcare, Piscataway, NJ) by ...
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Association of Fibroblast Growth Factor-2 (FGF-2) Immunoexpression with Histopathology Grade of Meningioma
... and 2, while the authors divided grade 1 and combined grades 2 and 3 based on tumor biological ...a growth factor, plays a role greater in cell proliferation and angiogenesis in higher grade ...
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The synthetic inhibitor of Fibroblast Growth Factor Receptor PD166866 controls negatively the growth of tumor cells in culture
... The TUNEL assay is an experimental protocol allowing the detection of DNA fragmentation. The specificity of this assay has been disputed but modifications done to the original method [21] improved its accuracy [22]. ...
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Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting
... (Figure 2) ...During receptor activation, the kinase domains autophosphorylate one another in the dimer, firstly at Y653 (FGFR1) of the YYKK motif in the activation loop (A-loop) ...of receptor ...
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