Fibroblast growth factor receptor 3
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein
... responsible factor, we tested several candidate tyrosine kinases that are highly expressed in keratinocytes for binding to BPV-1 ...E2. Fibroblast growth factor receptor 3 ...
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Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3
... Fibroblast growth factor receptor 3 (FGFR3) plays an important regulatory role in tumor cell proliferation and drug resistance. FGFR3 is often constitutively active in many tumors. To ...
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Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma
... the fibroblast growth factor receptor 3 ( FGFR3 ) are well described in UC and have led to ex- tensive clinical investigations evaluating FGFR3 inhibi- tors ...
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Original Article Nuclear translocation of fibroblast growth factor receptor 3 and its significance in pancreatic cancer
... Fibroblast growth factor receptor 3 (FGFR3) belongs to a high affinity cell surface-associat- ed receptor family that is highly conserved throughout evolution ...chemoresistance, ...
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In situ imaging of quantum dot-AZD4547 conjugates for tracking the dynamic behavior of fibroblast growth factor receptor 3
... Flexstation 3 microplate reader (Molecular Devices LLC, Sunnyvale, CA, ...M, 3 μ M, 1 μ M, 300 nM, 100 nM, 30 nM, 10 nM, 3 nM, 1 nM, 300 pM, 100 pM, 30 pM, and 10 pM) of test compounds in the ...
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Fibroblast Growth Factor Receptor 3 Deficiency Does Not Impair the Osteoanabolic Action of Parathyroid Hormone on Mice
... Tibiae and femora were fixed in 4% paraformaldehyde in 0.1 M phosphate buffer at 4°C overnight, decalcified in 0.5M EDTA-PBS for 10 days and embedded with paraffin. Five μm thick sections were stained with ...
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Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes
... [15,16]. Growth plate chondrocytes have active telomerase [43], yet exhibit senescence at an earlier age relative to most somatic cells [23] undergoing only 3 to 5 rounds of mi- tosis before differentiation ...
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Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers
... Parental (that is, scrambled shRNA) and FGFR1- manipulated D2.A1 cells were injected into the lateral tail veins of 5-week-old female BALB/C mice (The Jackson Laboratory, Bar Harbor, ME, USA). Where indicated, mice ...
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The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... Total RNA from tumor tissues was extracted using Trizol (Thermo Fisher Scientific, Waltham, MA, USA) according to the manufacturer’s instructions. Real-time quantitative poly- merase chain reaction (qPCR) was carried out ...
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Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting
... Additional structural features of the kinase domain, including Asp-Phe-Gly (DFG)-motif conformation and kinase hydrophobic spines, are indicators of kinase activity status [59,60]. The DFG-motif, located at the start of ...
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Original Article Expression of fibroblast growth factor receptor 1, fibroblast growth factor 2, phosphatidyl inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma of the lung
... which lead to cancer development [5, 6]. FGF2 is a potent stimulator of angiogenesis, and has a high-affinity for binding to FGFR1. Increased levels of FGF2, FGFR1, and FGFR2 proteins have been demonstrated in NSCLC cell ...
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Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells
... that, fibroblast growth factor 2 (FGFR2), signalling via ribosomal S6 kinase 2 (RSK2), promotes progression of breast cancer ...progesterone receptor (PR), whose activity in BCa cells can be ...
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Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer
... When patients were grouped according to FGFR4 staining intensity, no significant association was observed between FGFR4 expression and gender or age. Analysis with regard to the pre-treatment or post-treatment tumor ...
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins
... cells. Cells were incubated on cold with streptavidin- AF550 to label cell surface SBP-FGFR1 and then shifted for 1 h to 37 °C to allow for receptor endocytosis. SBP-FGFR1 was internalized at these conditions and ...
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Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies
... chromatin) and scanty cytoplasm. Immunohistochemistry also showed cells positive for CD3 and CD99. Immunophenotyping suggested T-cell lymphoblastic lymphoma with B lymphoid subset (Figure 1, Table 1). Conventional ...
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Analysis of fibroblast growth factor-heparin interactions
... of fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF ...
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Prognostic roles for fibroblast growth factor receptor family members in malignant peripheral nerve sheath tumor
... Materials and Methods: We performed microarray‑based comparative genomic hybridization (aCGH) profiling of two cohorts of primary MPNST tissue samples including 25 patients treated at The University of Texas MD Anderson ...
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Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures
... Fibroblast growth factors (FGFs) are involved in controlling a variety of biological functions including mitogenesis, differentia- tion, chemotaxis, angiogenesis, and wound healing (Burgess et ...related ...
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Original Article Fibroblast growth factor receptor 4 is not an independent prognostic biomarker in patients with lung adenocarcinoma
... ponatinib [AP24534], and nintedanib [BIBF 1120]) could exert growth inhibi- tion effect in FGFR1 overexpressed NSCLC cells in vitro and xenograft mod- els in vivo [16, 17]. Moreover, FGFR1/3 gene fusions ...
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Basic Fibroblast Growth Factor (bFGF), Fibroblast Growth Factor Receptor 1 (FGFR1), Transforming (Growth Factor Beta (TGF-) and Chromogranin A (CgA) Appearance in Congenital Intra-abdominal Adhesions in Children under One Year of Age
... the 3 divisions of the GI tract (foregut, midgut, hindgut) herniate out from the abdominal cavity, where they then undergo a 270º counterclockwise rotation around the superior mesenteric ...
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