Fibroblast growth factor receptor 4
Original Article Fibroblast growth factor receptor 4 is not an independent prognostic biomarker in patients with lung adenocarcinoma
... Received March 2, 2016; Accepted August 15, 2016; Epub November 15, 2016; Published November 30, 2016 Abstract: The aim of this study was to evaluate the clinical significance of fibroblast growth ...
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Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival
... cell growth, we identified fibroblast growth factor receptor 4 (FGFR4) as a potential mediator of cell ...secrete fibroblast growth factor 19 (FGF19), a ...
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Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer
... (CRC), fibroblast growth factor receptor 4 (FGFR4) is upregulated and acts as an ...this receptor on the response to neoadjuvant radiotherapy by analyzing its levels in rectal ...
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The prognostic significance of fibroblast growth factor receptor 4 in non-small-cell lung cancer
... at 4 ° C for 30 minutes, the supernatant was transferred into another tube and protein concentration was tested by Bradford method, followed by mixing with 2 × loading buffer and boiling for 10 minutes for protein ...
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Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures
... In this study we examined the in vivo and in vitro expression and localisation of FGFR4 and osteopontin in 1-day-old murine calvaria and primary osteoblast cultures. Unlike previous studies that failed to show FGFR4 ...
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Lepidopteran Ortholog of Drosophila Breathless Is a Receptor for the Baculovirus Fibroblast Growth Factor
... Previous studies have reported that after occluded-derived virus infection of the midgut cells, tracheal epithelial cells become infected, and then budded viruses appear in the he- molymph, followed by the infection of ...
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Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor
... Basic fibroblast growth factor (bFGF) has been shown to stimulate cell proliferation after vascular ...affinity receptor and a cell-surface heparan sulfate ...platelet factor 4 ...
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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... of rs2981582 is strongly associated with ER-positive but not ER-negative breast cancer [60]. Indeed, further analysis revealed that rs2981582 is associated with all breast cancer tumor types except ER-/PR- tumors [61, ...
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Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer
... The paraffin-embedded human lung tumor tissue array containing 61 different lung tumors (22 adenocarcinoma, 28 squamous cell carcinoma, 6 alveolar carcinoma, 1 large cell carcinoma and 4 small cell carcinoma) were ...
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The structure and function of vertebrate fibroblast growth factor receptor 1
... FGF receptor genes it is likely that the human FGFR1 gene is comprised of 19 exons ...secreted receptor isoforms lacking the kinase domain have been shown to result from alternative splicing involving ...
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Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study
... epidermal growth factor; EN-RAGE: protein S100-A12; ESM-1: endothe- lial cell-specific molecule 1; FABP4: fatty acid-binding protein, adipocyte; FAS: tumor necrosis factor receptor superfamily ...
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2 induced catabolic activities in human articular chondrocytes
... Progressive damage to articular cartilage is a hallmark of OA, and a principal cause of tissue break-down is the destruction rather than formation of the cartilage extra- cellular matrix by chondrocytes. Thus, metabolic ...
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The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... A total of 143 patients with GC with complete medical records from the First Affiliated Hospital of Zhengzhou University from 2011 to 2012 were enrolled. All of them had received total or subtotal gastrectomy with ...
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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
... fibroblast cell line (BJ) with a physiological FGFR level. The FGFR-dependent conjugate toxicity in U2OS FGFR1/U2OS cell lines confirms the specificity of the drug delivery via the FGF1–FGFR interaction. The cell ...
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The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor
... for the DNA synthesis assay up to the addition of growth factors. At the times indicated, Rama 27 cells were washed twice with ice-cold Tris-buffered saline (TBS) contained 100 μM sodium vanadate and then lysed in ...
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The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation
... in growth medium supplemented with puromycin (2 ...in growth medium for 2-3 ...anchorage-independent growth potential, Rat-1 cells stably expressing either the pBabe-puro empty vector or encoding ...
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The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
... BRG1-associated factor 60; Cdc42: cell division control protein 42; CDK: cyclin-dependent kinase; Cdo: cell adhesion molecule-related/downregulated by oncogenes; CIP/KIP: cyclin- dependent kinase-interacting ...
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STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
... Epidermal growth factor receptor; ER: Estrogen receptor; EZH2: Enhancer of zeste homolog 2; FAK: Focal adhesion kinase; FGFR: Fibroblast growth factor receptor; ...
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Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review
... multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1–3, fibroblast growth factor receptor (FGFR) ...
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Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH
... PTH: fibroblast growth factor, epidermal growth factor, and insulin stimulated chondrocyte proliferation irrespective of cartilage ...
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