fibroblast growth factor signaling
Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... PDGF-B is an important stabilizer of blood-vessels, working as a chemotactic and proliferative agent on vas- cular smooth muscle cells (VSMCs) and pericytes [25-27]. Nissen et al. investigated the possibility of inter- ...
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The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model
... Several pioneering experiments with cells cultured in or on hydrogels comprised of natural ECM proteins or synthetic biomaterials investigated the effect of matrix stiffness on valve cell phenotype. For instance, it was ...
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Fibroblast growth factor-2 stimulates proliferation of human adipose-derived stem cells via Src activation
... four signaling tyrosine kinase FGF receptors (FGFRs) and a class of low affinity receptors, the hepa- ran sulfate proteoglycans ...their signaling receptors is regulated by protein or proteoglycan ...
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Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis
... the fibroblast growth factor (FGF) family coupled with an accessory molecule of heparin sulfate proteoglycan ...intracellular signaling of multiple signal transduction pathways including the ...
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... More recently, second-generation inhibitors targeting FGFRs with high selectivity have been developed (Table 5, Figure 4). For example, Debio 1347, developed by Debiopharm Group, a Swiss-based global biopharmaceutical ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... FGF signaling, it was of interest to investigate whether it interacted with the receptor during ...FGF signaling, Flg is found in the membrane fraction, as it is a membrane-associated protein (Meyers et ...
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Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers
... out- growth is stimulated specifically by the expression of FGFR1-β and, conversely, is inhibited by that of ...cell growth (Additional file 10: Figure ...
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The importance of antiangiogenic effect in multiple myeloma treatment
... vessel growth and formation in cancer ...or signaling function involved in angiogenesis, such as growth factors ...VEGF, fibroblast growth fac- tor – FGF, epidermal growth ...
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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
... (Cell Signaling Technology, Danvers, MA, USA), anti-phospho-FGFR antibody (Cell Signaling Technology), and anti- γ -tubulin anti body (Sigma-Aldrich) as a loading ...
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Alveologenesis: key cellular players and fibroblast growth factor 10 signaling
... endothelial growth factor receptor 2 (Vegfr2 or Flk-1) as an early marker ...endothelial growth factor (VEGF) signaling with three dif- ferent VEGF receptor inhibitors (SU5416, Ki8751, ...
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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
... Multiple genetic aberrations in FGFR2 triggering the activation of up and/or downstream FGFR2 signaling pathways have been identified in breast cancer. For instance, 6 out of 165 (3.6%) of triple-negative breast ...
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Intrauterine growth restriction and placental angiogenesis
... vascular growth begins early in pregnancy and continues throughout gestation ...vascular growth changes from branching to non-branching angiogenesis due to the for- mation of mature intermediate villi that ...
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Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
... Somatic mutations in FGFR2 have been associated with a number of human cancers (Jang et al., 2001; Pollock et al., 2007; Dutt et al., 2008; Byron et al., 2010), whereas missense germline mutations of the fgfr2 gene are ...
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Caries Induced FGF 2 Expression in Human Dental Pulp
... angiogenic growth factor (FGF-2) has shown its presence in pulp tissue and its potentiating and synergistic effects on other major angiogenic inducers (VEGF and TGF- β ) (Derringer et ...
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Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
... GFs: growth factors; GF: growth factor; NTFs: neurotrophic factors; bFGF: basic fibroblast growth factor; NGF: nerve growth factor; DPN: diabetic peripheral ...
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The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
... The growth factors and angiopoietins determined were summarized by using geometric means and interquartile ranges ...compare growth-factor concentrations between groups, by using log-transformed ...
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Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
... platelet-derived growth factor (PDGF)/PDGF receptor pathway is thought to play a critical role in fibrogenesis of the ...Other growth factors, including fibroblast growth factor ...
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Sleeve gastrectomy attenuates high fat diet-induced non-alcoholic fatty liver disease
... Fibroblast growth factor 21 (FGF21), a member of the fibroblast growth factor family, has emerged as a leading candidate in the regulation of energy homeostasis, glucose-lipid ...
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Antiangiogenic Effect of Tridax procumbens(L.) Leaf Extract By Chick Chorioallantoic Membrane (CAM) Assay
... Cancer is the life threatening and dreadful disease characterized by the abnormal and uncontrolled proliferation and migration of cells leading tumor formation. Conventional treatment chemotherapy could cause adverse and ...
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Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
... pro-angiogenic factor (VEGF) and anti-angiogenic factor (TSP-1) between N/R and I primary ...pro-angiogenic factor which acts early in angiogenesis inducing an increase in blood vessel per- meability ...
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