Fibroblast like synovial cells
Osteogenic differentiation of fibroblast like synovial cells in rheumatoid arthritis is induced by microRNA 218 through a ROBO/Slit pathway
... pathogenesis, fibroblast-like synovial cells (FLS) are ...hyperplastic synovial tissue, also called the pannus, destroys cartilage and ...
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Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast like synovial cells through high mobility group box chromosomal protein 1
... FLS: fibroblast- like synovial cells; HMGB1: high mobility group box chromosomal protein 1; LC3: microtubule-associated protein 1 light chain 3; LC3-II: microtubule- associated protein 1 light ...
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Interleukin 34 produced by human fibroblast like synovial cells in rheumatoid arthritis supports osteoclastogenesis
... FLS: fibroblast-like synovial cells; HRP: horseradish peroxidase; IL-34: interleukin-34; JNK: c-Jun N-terminal kinase; MAPK: mitogen-activated protein kinase; M-CSF: macrophage colony- ...
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Anti-DR5 mAb inhibits proliferation of human fibroblast-like synovial cells and reduces their cytokine secretion in vitro
... The synovial cells were obtained from synovial tissue using trypsin combined with type ii ...collagenase. synovial cells included types a, B, and ...cultured synovial ...
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Effects of hyaluronan treatment on lipopolysaccharide challenged fibroblast like synovial cells
... The fibroblast-like synovial cells used in this study are the largest proportion of cells found in the synovium, but are not the only ...the fibroblast-like ...
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Fibroblast like synovial cells from normal and inflamed knee joints differently affect the expression of pain related receptors in sensory neurones: a co culture study
... FLS cells isolated from the knee joint of normal adult rats, a similar proportion of DRG neurones ...FLS cells from the inflamed knee of AIA rats, the proportion of neurones expressing NK1 ...
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Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast like synovial cells
... AGEs extensively accumulate in cartilage collagen with age [27]. In a canine model of OA it has been shown that higher cartilage AGE levels increase the severity of OA and thus pro- vide evidence for a molecular ...
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Fibroblast-Like Synovial Cells in Rheumatoid Arthritis – the Impact of Infliximab on Hexosaminidase Activity
... Lysosomal exoglycosidases belong to the group of lysosomal enzymes that catalyzes oligosaccha- ride chains of glycoproteins, glycolipids and pro- teoglycans in acid medium [7]. Among them is N-acetyl-β-D-hexosaminidase ...
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NF κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony stimulating factor
... RA fibroblast-like synovial cells (FLS) were prepared from the synovial tissues as described previously [22], and were cul- tured in DMEM with heat-inactivated 10% FCS (Sigma- ...
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Connexin43 enhances the expression of osteoarthritis associated genes in synovial fibroblasts in culture
... in synovial cells is sufficient to enhance the ex- pression of OA-associated catabolic and inflammatory genes in both rabbit and human synovial ...and synovial cells in OA [13,22], as ...
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Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis
... of synovial membrane were obtained from patients with knee OA undergoing joint replacement ...on fibroblast-like synovial cells (FLS) and synovial ...
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Transcriptional profiles discriminate bone marrow derived and synovium derived mesenchymal stem cells
... stem cells (MSC) may be isolated from the synovial membrane by the same protocol as that used for synovial fibroblast cultivation, suggesting that MSC correspond to a subset of the adherent ...
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Functional analysis of an arthritogenic synovial fibroblast
... on fibroblast proliferation and structural remodeling [57,58], were found to be elevated in the syn- ovial fluid of RA patients ...on synovial biology ...transformed cells that contribute to the ...
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Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... + cells in RA synovium. We found that chemerin was expressed on synovial lining and sub- lining cells and on endothelial ...the synovial fluid was much higher in RA than that in OA (358 ng/ml ...
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The tumour associated glycoprotein podoplanin is expressed in fibroblast like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis
... reticular cells of lymphoid organs and alveolar type I cells ...interstitial cells in human endolymphatic tissue of the inner ear ...epithelial cells induced a dentritic cell morphology and ...
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Fibroblast biology Signals targeting the synovial fibroblast in arthritis
... Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface ...
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The synovial proteome: analysis of fibroblast like synoviocytes
... examine cells and tissues from normal and pathologic ...in synovial tissues derived from osteoarthritis patients and RA patients recently highlighted this problem ...
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Parallel comparison of fibroblast like synoviocytes from the surgically removed hyperplastic synovial tissues of rheumatoid arthritis and osteoarthritis patients
... MTX also inhibited up-regulated inflammatory markers [18]. TNF-α significantly induced RA FLS [19–21] and modulated a panel of pro-inflammatory cytokines that act as an essential promoter of inflammation [22]. TNF-α ...
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p53 predominantly regulates IL 6 production and suppresses synovial inflammation in fibroblast like synoviocytes and adjuvant induced arthritis
... Our preliminary research revealed that the p53 activa- tor (Nutlin) ameliorated adjuvant-induced arthritis (AIA) in Lewis rats, although the effect of p53 did not appear to be mediated by inducing apoptosis in FLS, and ...
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Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
... immune cells, leading to a considerable improvement in the management of RA ...stem cells (MSCs) with the ability to differentiate into cartilage are present in joint tissues raises an opportunity for ...
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