Fibroblast-like synoviocyte
Adrenomedullin increases fibroblast like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
... receptor- like receptor; ...FLS: fibroblast-like synoviocyte; HUVEC: human umbilical vein endothelial cell; ICAM: intercellular adhesion molecule; IP: immunoprecipitation; OA: osteoarthritis; ...
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Cia5dregulates a new fibroblast like synoviocyte invasion associated gene expression signature
... The fibroblast-like synoviocyte (FLS) is a key player in this process, and its numbers are markedly increased in the hyperplastic synovial pannus of RA and rodent models of arthritis ...
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Liver X Receptor Regulates Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness, Matrix Metalloproteinase 2 Activation, Interleukin-6 and CXCL10
... Fibroblast-like synoviocyte (FLS) invasiveness correlates with articular damage in rheumatoid arthritis (RA), yet little is known about its ...
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Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6
... RA-FLSs represent severe factors associated with joint cartilage erosion, as a consequence of RA-FLSs tumor-like behavior such as increased cell number, inflammatory re- sponse mediation, and aggressive phenotypes ...
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The involvement of follistatin like protein 1 in osteoarthritis by elevating NF κB mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation
... Previous work suggests that activation of the NF-κB signaling pathway is associated with synovial fibroblast hyperplasia, and thus contributes to OA progression [30]. Thus, we wondered if FSTL1 promotes the pro- ...
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Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation
... Targeting fibroblast-like synovi- ocytes (FLS), the cells that form the synovial intimal lining of diarthrodial joints, represents an approach that could address this unmet medical need ...
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Fibroblast like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis
... (RA), fibroblast-like synoviocytes (FLS) are the most common cell type at the pannus – cartilage junction and contribute to joint destruction through their production of cytokines, chemokines, and matrix- ...
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Building the synovium: cadherin 11 mediates fibroblast like synoviocyte cell to cell adhesion
... Cadherin-11 mediates lining layer-like formation. Discrete regions of tissue culture dishes were coated with fibronectin (FN), followed by blocking of the entire dish with bovine serum albumin (BSA). L-cells were ...
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Effect of a small molecule inhibitor of nuclear factor κB nuclear translocation in a murine model of arthritis and cultured human synovial cells
... Using fibroblast-like synoviocyte (FLS) cell lines established from patients with rheumatoid arthritis (RA), NF- κ B activity was examined by electrophoretic mobility shift ...
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Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... FLS: fibroblast-like synoviocyte; IFN: interferon; IL: interleukin; JNK: c-Jun N- terminal kinase; mAb: monoclonal antibody; MAPK: mitogen-activated protein kinase; MEK: mitogen-activated protein ...
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Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast like synoviocytes from nitric oxide induced apoptosis
... Effect of Hsp70 knock-down on nitric oxide-induced apoptosis in rheumatoid arthritis fibroblast-like synoviocyte After treatment with SNP 1 mM for 24 hours, cell blebbing and cytoplasmic[r] ...
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Regeneration of full-thickness skin defects by differentiated adipose-derived stem cells into fibroblast-like cells by fibroblast-conditioned medium
... into fibroblast cells in order to stimulate wound healing in a skin defect ...into fibroblast-like cells, we performed FACS analysis and verified that both F-CM- treated hADSCs and HS27 cells ...
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The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro
... We first evaluated the effect of PFD on fibroblast prolif- eration. PFD decreased the number of fibroblasts after 24 h and 72 h of culture without causing detachment of cells as evaluated by light microscopy (Fig. ...
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Original Article Directed differentiation of skin-derived precursors into fibroblast-like cells
... basic fibroblast growth factor (bFGF; 40 ng/ml, Peprotech EC LTD); Hank’s balanced salt solu- tion (HBSS; Invitrogen); trypsin (Gibco BRL, Rockville, MD); recombinant human CTGF (Gibco BRL); collagen I antibody ...
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Human alveolar macrophages produce a fibroblast like collagenase and collagenase inhibitor
... Collagenase inhibitory activity was also present in the macrophage-conditioned medium, and was accounted for by an antigen that showed immunologic and functional identity with the collag[r] ...
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Ecotropic murine leukemia virus-induced fusion of murine cells.
... Cell lines used in this study Cell line B559 Mouse fibroblast Mouse, transformed fibroblast Mouse fibroblast Mouse fibroblast Mouse fibroblast Mouse fibroblast Mouse fibroblast Mouse fib[r] ...
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In Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
... equine fibroblast-like synoviocytes viability, using the 3-(4,4-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) reduction assay and trypan blue ...
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Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
... FLS: fibroblast-like synoviocytes; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IgG: immunoglobulin G; IL: interleukin; PDGF: platelet-derived growth ...
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PUMA mediated apoptosis in fibroblast like synoviocytes does not require p53
... Several therapeutic approaches to RA have focused on induc- ing apoptosis in the synovium, especially the intimal lining [2,4]. This region is populated by macrophage-like and fibrob- last-like synoviocytes ...
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Fibroblast-Like Synovial Cells in Rheumatoid Arthritis – the Impact of Infliximab on Hexosaminidase Activity
... well known that glycosidases play a role in cartilage degradation similarly to matrix metalloproteinases. Carbohydrate cleavage products, generated by gly- cosidases including HEX, are released from degrad- ing cartilage ...
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