Fibroblast-like synoviocytes (FLSs)
Resistin upregulates chemokine production by fibroblast like synoviocytes from patients with rheumatoid arthritis
... Rheumatoid arthritis (RA) is characterized by chronic polyarthritis. Inflammatory mediators, such as cytokines and chemokines, contribute to the pathogenesis of RA. The immunomodulatory properties of adipokines in RA ...
10
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... with fibroblast-like synoviocytes (FLSs) derived from patients with ...surgery. FLSs were isolated and grown in Dulbecco's modified essential medium (low glucose) (Gibco-BRL, now part ...
10
Evaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study
... Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, ...
6
Characterisation of fibroblast like synoviocytes from a murine model of joint inflammation
... FLS: fibroblast-like synoviocytes; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IgG: immunoglobulin G; IL: interleukin; PDGF: platelet-derived ...
15
Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1β-stimulated fibroblast-like synoviocytes
... Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [17,18] that secretes various substances (adipo- kines) including tumor necrosis factor-a (TNF-a), ...
7
RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast like synoviocytes
... Rheumatoid arthritis (RA) is an immune-mediated disorder induced by chronic and refractory autoimmunity in the synovial joints, which leads to the damage of the cartilage and bone. RA affects approximately 1% of the ...
10
PUMA mediated apoptosis in fibroblast like synoviocytes does not require p53
... PUMA (p53-upregulated modulator of apoptosis) is a pro- apoptotic gene that can induce rapid cell death through a p53- dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in ...
7
Glutaminase 1 plays a key role in the cell growth of fibroblast like synoviocytes in rheumatoid arthritis
... FLS: Fibroblast-like synoviocytes; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GC/MS: Gas chromatography-mass spectrometry; GLS: Glutaminase; HK: Hexokinase; IL: Interleukin; LPS: ...
10
Anti inflammatory and antiarthritic effects of piperine in human interleukin 1β stimulated fibroblast like synoviocytes and in rat arthritis models
... In this study, the anti-inflammatory effects of piperine were tested in IL1β-stimulated rheumatoid arthritis fibroblast-like synoviocytes derived from patients with rheumatoid arthritis.[r] ...
9
PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis
... It has been proposed that fibroblast-like synoviocytes (FLS) are actively involved in chronic inflammatory reactions. The molecular mechanisms of their sus- tained activation might be contributed to ...
13
Expression of interleukin 18 receptor in fibroblast like synoviocytes
... An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined ...
8
MLN51and GM CSF involvement in the proliferation of fibroblast like synoviocytes in the pathogenesis of rheumatoid arthritis
... RA FLSs with SFs containing anti-GM- CSF mAb significantly impaired the SF-mediated proliferation efficacy of FLSs (Figure ...RA FLSs, further supporting the results ...RA FLSs (2–14) in ...
11
In Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
... Synovial fluid samples were aspirated with syringes containing sodium heparin (Heparodic, Caspiantamin, Gilan, Iran) from metacarpophalangeal joints using aseptic techniques from six skeletally mature (4-7 years old) ...
7
The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro
... Second, the effect of PFD on SpA FLS expression of membrane molecules and secretion of cytokines and chemokines was studied. Previously, PFD has been shown to inhibit MHC-II molecules in animal models of transplantation ...
9
Extracellular heat shock protein 70 inhibits tumour necrosis factor α induced proinflammatory mediator production in fibroblast like synoviocytes
... RA FLSs in response to TNF-α and IL-1 ...RA FLSs, and activate intracellular anti-inflammatory signal transduction pathways such as JAK2-STAT3-SOCS3, which can inhibit the TNF-α induced degradation of IκB ...
11
Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... RA FLSs and chemerin itself activate FLSs to enhance the production of IL-6 and ...RA FLSs, leading to persistent amplification of inflammation in the RA synovium, possibly in an auto- crine or ...
14
Innate immunity triggers IL 32 expression by fibroblast like synoviocytes in rheumatoid arthritis
... that FLSs, which constitute the synovial lining, are key actors in pannus formation and the subsequent destruction of cartilage and bone in the joint ...of FLSs may be linked either to the cytokine ...
11
Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... arthritis fibroblast-like synoviocytes (RA FLSs). (a) FLSs were stimulated for 2 hours with celecoxib at indicated concentrations or for 4 hours with tumor necrosis factor-related ...
11
Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
... damage. Like MSCs, fibroblast-like synoviocytes (FLSs) are part of the stroma of the synovial ...RA, FLSs undergo proliferation and contribute to the formation of the deleterious ...
9
promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and this is
... Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLSs) and synovial macrophages (SMs), are crucial for the progression of rheumatoid arthritis (RA) as they form ...
15