Filaggrin Gene
Loss of function variants in the filaggrin gene are a significant risk factor for peanut allergy
... Trust. Filaggrin research in the McLean laboratory is supported by grants from the British Skin Foundation, National Eczema Society, Medical Research Council (ref G0700314), the Wellcome Trust (ref 090066/B/09/Z ...
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Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population
... the filaggrin gene in asthma and potential importance of atopy in this ...FLG gene and asthma [10, 14, 17, 20], but interestingly in our study the association seems to be with non-allergic asthma ...
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Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status
... Recently, our research team found a strong and significant association between loss-of-function (LOF) mutations in filaggrin (FLG), a gene that encodes a skin barrier protein, in European and Canadian ...
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Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E
... of filaggrin gene mutations has previously been detected in AD, AR and BA, but the significance of serum levels of filaggrin protein in the initiation and development explaining the mechanism of ...
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Filaggrin Mutation in Korean Patients with Atopic Dermatitis
... Purpose: Atopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between ...
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Real time PCR quantification of the canine filaggrin orthologue in the skin of atopic and non atopic dogs: a pilot study
... investigating filaggrin mRNA expression in an experimental model of canine AD reported significant differences between atopic and non- atopic Beagles, with atopic animals showing less filaggrin mRNA ...
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Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort
... The filaggrin gene (FLG) in humans encodes a polyprotein precursor (profilaggrin) which, after post-transla- tional processing, results in several individual filaggrin polypep- tides ...[3]. ...
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Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis
... of filaggrin represent us a major advance in the understanding of defec- tive barrier ...the filaggrin gene ( FLG ) can not only cause ichthyosis vulgaris, the most common disorder of keratinization, ...
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South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss of function mutations in filaggrin
... Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are the strongest known genetic risk factors for atopic dermatitis (AD). The genetic architecture of FLG mutations is well estab- lished in ...
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The effect of Psoroptes ovis infestation on ovine epidermal barrier function
... both filaggrin and lori- crin protein in the stratum corneum by 24 hpi demonstra- ting the involvement of these integral constituents of the cornified envelope in the pathology of sheep ...of gene ...
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Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
... mouse filaggrin [with a probability based Mowse score of 177; this is the 2 10 log(P ), where P is the probability that the observed match is a random event; protein scores greater than 75 are considered ...
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Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?
... The FLG gene involves at least ten highly homolog repeat sequences. The primer sequences or primer design for detection of FLG mutations was based on the report of Sandilands et al. [32]. In total we selected 13 ...
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Chitosan-based nanoformulated (–)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis
... Figure 6 effect of topically applied free egcg and nanoegcg on expression of epidermal differentiation markers and JunB in IMQ-treated mouse skin. (A–P) Photomicrographs showing expression of various epidermal ...
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The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus
... Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. Extensive recent studies have shed ...
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Filaggrin stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis
... The second major finding of this global transcriptomic analysis is the dysregulation of lipid metabolic pathways both in the unstratified case-control comparison (see Fig E4, A) and in the FLG wild-type case-control ...
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Normal Human Epidermal Keratinocytes Express In Vitro Specific Molecular Forms of (Pro)Filaggrin Recognized by Rheumatoid Arthritis-Associated Antifilaggrin Autoantibodies
... One-dimensional immunoblotting reactivity of MAbs, RA sera, and control sera to proteins extracted with low-salt buffer or with urea from cultured keratinocytes and normal human epidermi[r] ...
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Towards gene network estimation with structure learning
... comparison, it is categorised into one of the three categories. The control value was set as the average expression level of the gene across experiments. To discretize the data, a threshold was set to the ratio ...
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Strüver, Kay (2018): Development and characterization of in-vitro models for filaggrin associated skin diseases. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... proteins filaggrin and its precursor profilaggrin play a major role in skin ...similar filaggrin monomers in the middle of the polyprotein, and a specific C-terminal domain ...protein filaggrin is ...
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Intracellular functions and interactions of age-related macular degeneration-associated variant B cystatin C.
... The gene coding for the protein, designated CST3, was found to be located in chromosome 20 in 1989 (Abrahamson et ...the gene completely described a year later (Abrahamson et ...
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