Filamin A
A structural and functional investigation into the filamin A G2593E mutation : implications for neurological disease : a thesis presented in partial fulfillment of a Master of Philosophy (Science) (Biochemistry) at the Institute of Molecular BioSciences, Massey University, Palmerston North
... human filamin a (hsFLNa) is an actin binding protein, which modulates the properties of the actin cytoskeleton and plays a major role in maintaining the integrity of plasma membrane associated actin, the ...
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The filamin A actin binding domain structure and function: implications for a gain of function mechanism for the otopalatodigital syndrome: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand
... The filamin family act as scaffolding proteins associating with actin filaments, acting through a highly conserved actin binding domain ...the filamin A gene cause a wide range of disease symptoms in humans ...
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Lung disease associated with filamin A gene mutation: a case report
... gration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, trans- membrane receptor complexes, and second ...
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Ureaplasma parvum infection alters filamin a dynamics in host cells
... of filamin A that was detected in the iTRAQ ...of filamin A that was noted in ...lated filamin A at serine 2152 worked in rat bladder tis- sues so we could not determine if this also occurred in ...
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RNase L Interacts with Filamin A To Regulate Actin Dynamics and Barrier Function for Viral Entry
... lacking Filamin A and A7 cells derived from M2 cells by stably ex- pressing Filamin A (provided by ...MA), Filamin A (monoclonal) was from Neomarkers (Fremont, CA), and polyclonal antibody was from ...
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Normal X inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice a model of human Filamin A (FLNA) diseases
... X-linked, filamin A gene (FLNA) mutations, display a range of disorders and X-inactivation mosaicism is sometimes quantitatively ...X-linked filamin A (Flna) nonsense mutation have variable eye, skeletal ...
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Expression and purification of CFM2 and filamin A repeat 10 domain : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Manawatu, New Zealand
... Dictyostelium Filamin(ddfilamin) ...of Filamin is 250kDa and forms a V shaped elongated structure [16, ...of Filamin A (aa 1-264) contains an ABD, this domain consists of two calponin homology ...
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Binding of pro prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer
... diseases, whereas its function outside the nervous system remains unclear. Here, we report that human pancreatic ductal adenocarcinoma (PDAC) cell lines expressed PrP. However, the PrP was neither glycosylated nor ...
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Filamin A phosphorylation by Akt promotes cell migration in response to arsenic
... of filamin A predicts poorer overall survival of the patients who were never-smoked ...of filamin A appeared to be no effect on the overall survival among those patients who were current or former smokers ...
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Filamin A and formin 2 dependent endocytosis regulates proliferation via the canonical Wnt pathway
... Actin-associated proteins regulate multiple cellular processes, including proliferation and differentiation, but the molecular mechanisms underlying these processes are unclear. Here, we report that the actin-binding ...
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Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
... Filamin A interacting protein 1-like (FILIP1L) expression, which is decreased in various cancers, may inhibit carcinogenesis. In this study, we evaluated the effects of FILIP1L on oncogenic behavior and prognosis ...
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Cell type specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning
... several filamin repeats. Each filamin repeat is ~100 amino acids long and contains an immunoglobulin fold (Noegel et ...with filamin A (FLNA) being the most widely ...alter filamin function ...
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Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells
... of filamin C was commonly detected in various types of human cancers by analyzing the microarray datasets in Oncomine ...The filamin C mRNA level was significantly reduced in GC tissues based on the Cui ...
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A search for doxycycline dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctlgenes
... both filamin and fwd are involved in the function of ring canals, which are membrane-associated actin cytoskeletal structures that create intercellular bridges between germline cells during early mitotic divisions ...
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Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis
... cess that ensures efficient protein biosynthesis and minimizes the formation of misfolded states. However, the complexity of this process makes it extremely challenging to obtain structural char- acterizations of CTF ...
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