Filamin-A
Inhibition of Filamin-A Reduces Cancer Metastatic Potential
... of filamin-A in the cells (Figs 1 and ...of filamin-A in cell mobility[32-41]. To evaluate the impact of filamin-A status in cancer prognosis, Ai et ...identified filamin-A as a potential ...
11
Filamin A phosphorylation by Akt promotes cell migration in response to arsenic
... For regular Western blotting, the cell lysates were prepared by RIPA cell lysis buffer (Cell Signaling, Danvers, MA) followed by ultrasonication and centrifugation. The supernatants were aspirated and proteins were ...
11
Lung disease associated with filamin A gene mutation: a case report
... In this case report, we describe another confirmatory mutation in the gene encoding filamin A (FLNA) in a fe- male child with lung disease. Our patient was a female child who was confirmed to have a pathogenic ...
5
Complex roles of filamin-A mediated cytoskeleton network in cancer progression
... addition, Filamin-A acts as a scaffold for signaling molecules that mediate intracellular protein ...eton. Filamin-A regulates matrix–cytoskeleton signaling by virtue of binding to both actin networks and ...
12
Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
... Filamin A interacting protein 1-like (FILIP1L) expression, which is decreased in various cancers, may inhibit carcinogenesis. In this study, we evaluated the effects of FILIP1L on oncogenic behavior and prognosis ...
13
Ureaplasma parvum infection alters filamin a dynamics in host cells
... of filamin A that was detected in the iTRAQ ...of filamin A that was noted in ...lated filamin A at serine 2152 worked in rat bladder tis- sues so we could not determine if this also occurred in ...
13
Filamin A and formin 2 dependent endocytosis regulates proliferation via the canonical Wnt pathway
... Fig. 1. Filamin A (FlnA) interacts and overlaps with formin 2 (Fmn2) in developing mouse brain and neural cells. (A) FlnA directly interacts with Fmn2, as assessed by yeast two-hybrid assay. Filter assay ...
12
Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review
... encoding filamin A (at chromosomal locus Xq28) have been reported to cause a wide range of human diseases, such as cerebral periventricular nodular heteroto- pia (PVNH), cardiac valvular disease and skeletal ...
10
How does the interaction between the Filamin A repeat 10 domain and F actin lead to severe OPD skeletal disorders? : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand
... in Filamin A (FLNA) have been identified to cause distinctly different human diseases affecting the central nervous system, vascular system, or skeletal muscles; however, the molecular mechanisms of FLNA leading ...
18
A structural and functional investigation into the filamin A G2593E mutation : implications for neurological disease : a thesis presented in partial fulfillment of a Master of Philosophy (Science) (Biochemistry) at the Institute of Molecular BioSciences, Massey University, Palmerston North
... human filamin a (hsFLNa) is an actin binding protein, which modulates the properties of the actin cytoskeleton and plays a major role in maintaining the integrity of plasma membrane associated actin, the ...
10
Expression and purification of CFM2 and filamin A repeat 10 domain : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Manawatu, New Zealand
... Dictyostelium Filamin(ddfilamin) ...of Filamin is 250kDa and forms a V shaped elongated structure [16, ...of Filamin A (aa 1-264) contains an ABD, this domain consists of two calponin homology ...
134
Normal X inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice a model of human Filamin A (FLNA) diseases
... Filamin A is a cytoskeleton protein with multiple roles that binds to actin and other proteins in many cell types. It is encoded by an X-linked gene, designated FLNA in humans and Flna in mice; mutations in human ...
7
Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer’s disease
... interaction to a femtomolar affinity and enables the signaling. ERK1 and JNK kinases are activated to hyperphosphorylate tau. Hyperphosphorylated tau loses its function of stabilizing microtubules and dissociates from ...
9
Binding of pro prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer
... The cellular prion protein (PrP) is a highly conserved, widely expressed, glycosylphosphatidylinositol- anchored (GPI-anchored) cell surface glycoprotein. Since its discovery, most studies on PrP have focused on its role ...
13
Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy
... in filamin-A deficient ...[31-33]. Filamin-A has been reported to play a role in intracellular trafficking and redistribution of some proteins, such as epidermal growth factor receptors (EGFR) and furin ...
9
RNase L Interacts with Filamin A To Regulate Actin Dynamics and Barrier Function for Viral Entry
... lacking Filamin A and A7 cells derived from M2 cells by stably ex- pressing Filamin A (provided by ...MA), Filamin A (monoclonal) was from Neomarkers (Fremont, CA), and polyclonal antibody was from ...
14
Filamin : a family of mechanosensory scaffold proteins
... introduction filamin A is composed of an ABD followed by 24 Ig- like ...human filamin A Ig-like domains (Figure ...homologous filamin domains in the protein data bank (PDB) ...each filamin A ...
125
The filamin A actin binding domain structure and function: implications for a gain of function mechanism for the otopalatodigital syndrome: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand
... of filamin A, but still be associated with PVNH (Figure ...of filamin A (Andrew Sutherland-Smith, ...monomeric filamin A is not ...where filamin A null mouse embryonic fibroblasts are able to ...
170
How does the interaction between the Filamin A repeat 10 domain and F actin lead to severe OPD skeletal disorders? : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand
... the filamin monomer with a conserved structure as for other actin filament binding proteins such as; α-actinin, β-spectrin, fimbrin and utrophin (Gorlin ...
141
Kircher, Philipp (2016): Filamin A interacts with the co-activator MKL1 to promote the activity of transcription factor SRF and cell migration. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the filamin rod during stressful cytoskeletal situations might work as a method to protect the structure from being damaged or leading to prevention from fatal breaking issues (Popowicz ...
148