first intron
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
... the first intron from 0 to 100% independently of the expression level could be linked to the more variable and larger length of the intron and suggestive of a more complex role of this ...the ...
17
CTCF Binding to the First Intron of the Major Immediate Early (MIE) Gene of Human Cytomegalovirus (HCMV) Negatively Regulates MIE Gene Expression and HCMV Replication
... the first intron (intron A) of the MIE gene that interacts directly with ...the first intron to affect RNA polymerase II function during the early stages of viral ...(MCMV) ...
13
P Elements Inserted in the Vicinity of or Within the Drosophila snRNP SmD3 Gene Nested in the First Intron of the Ornithine Decarboxylase Antizyme Gene Affect Only the Expression of SmD3
... the first step in the synthesis of ...the first intron short first open reading frame 1 (ORF1) and a longer of the AZ (CG16747) gene (Ivanov et ...
10
Association study of TAAAA polymorphism in the first intron of p53 gene with risk of colorectal cancer in Iranian population
... Nowadays, in cancer therapy, researchers consider pro- cedures and molecular mechanisms related to carcino- genesis [10]. p53, as a tumor suppressor gene, have significant roles in many cellular processes including ...
5
Replication-dependent activation of the adenovirus major late promoter is mediated by the increased binding of a transcription factor to sequences in the first intron.
... The major late promoter MLP of human adenovirus type 2 or type 5 is typical of many cellular promoters in possessing two essential elements located 5' to the start site, the so-called up[r] ...
9
TWIST Represses Estrogen Receptor-alpha Expression by Recruiting the NuRD Protein Complex in Breast Cancer Cells
... the first intron amplified by primers P1 and P2 and the other in a 3’ non-coding region amplified by primers P5 and P6 ...the intron 7 of the human ESR1 gene ...
11
The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese
... Background: Genome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein ( ADT[r] ...
6
A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally parasitised population of Soay sheep
... Free-living Soay sheep (Ovis aries) on the island of Hirta, St Kilda, Scotland, are naturally parasitized by gastrointestinal nematodes, predominantly Teladorsagia circumcincta. In this paper we show that reduced faecal ...
12
Signatures of Selection in Natural Populations Exposed to Chronic Pollution.
... the first intron of the phase I xenobiotic metabolizing enzyme ...the first intron of CYP1A affects transcription or is linked to SNPs affecting ...
247
A Novel Chimeric Gene, siren, With Retroposed Promoter Sequence in the Drosophila bipectinata Complex
... In the case of siren, none of these characteristics were recognized for retroposition of CG11779. Especially, it is quite unlikely that the nonexon sequences (the 5 9 - untranscribed region and the first ...
9
Conserved Arrangement of Nested Genes at the Drosophila Gart Locus
... As all of the conserved regions that lie within the Gart purine gene first intron are no more than 5 kb downstream of the start of transcription, they are candidates [r] ...
15
CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum
... conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epigenetic mechanisms, includ- ing interaction with the var promoter, production of ...
13
Diverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attB
... an intron of the target gene; we found that this 40 bp insertion is well-tolerated as it does not ad- versely affect either intron splicing or subsequent trans- lation and function of the encoded ...to ...
8
Population Genomic Analysis Reveals No Evidence for GC-Biased Gene Conversion in Drosophila melanogaster.
... As our first test of whether gene conversion is GC-biased in D. melanogaster, we examined counts of AT ! GC versus GC!AT polymorphisms. Assuming base composition is at equilibrium, the null expectation is that ...
31
Detailed structure of the Drosophila melanogaster stellate genes and their transcripts.
... This indicates that the RNA start and the processing of the first Stellate intron is the same for the marked Stellate gene and the endogenous Stellate genes, at lea[r] ...
14
Abstract
... PEG− INTRON at a dose of ...c) Intron A at a dose 3 × 3 million units/week combined with ribavirin at a dose of 800 mg/day; 3) the costs of treatment with compa− rable therapeutic options (for a period of ...
10
The Association of Nucleobindin 2 Gene (NUCB2) Variants with Type 2 Diabetes Mellitus Among Iranian Azeri-Turkish Population
... Nesfatin-1, which is derived from the NEFA/nucleobindin 2 (NUCB2) precursor, is a satiety factor secreted by several tissues, including the hypothalamus. NUCB2 gene expression positively correlates with insulin secretory ...
8
Evolutionary significance and diversification of the phosphoglucose isomerase genes in vertebrates
... The first and/ or second flanking gene(s) was lost in some of the spe- ...two first adjacent upstream flanking genes: MPHOSPH6: (UFG1) and HSD17B2 (UFG2) of PGI1 isoform were ...three first adjacent ...
16
Trichinella pseudospiralis vs T spiralis thymidylate synthase gene structure and T pseudospiralis thymidylate synthase retrogene sequence
... an intron located 12 nt downstream, and ...Trichinella intron 3, animal (with the excep- tion of ...conserved intron, corresponding to Trichinella intron ...homologous intron, ...
10
Identifying the mechanisms of intron gain: progress and trends
... in intron gain when researchers identified short direct repeats flanking 43% of gained introns in Daphnia ...gained intron that was homologous to the mitochondrial 16S ribosomal subunit ...
10