flk-1
Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases
... All tissues were examined by two blinded observers using a 40× objective lens of a light microscope (Nikon, Tokyo, Japan) connected to a digital camera (Coolpix 990; Nikon). Ten fields of an immunostained section (von ...
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Expression Patterns of VEGF and Flk-1 in Human Endometrium during the Menstrual Cycle
... of Flk-1 in different compartments dur- ing menstrual cycle may reflect the balance of steroid hormone’s effect in the dynamic changes of the ...and Flk-1 expression in the human endo- metrial ...
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Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi’s Sarcoma Cells
... the Flk-1/KDR recep- tor (VEGFR-2) for ...the Flk-1 receptor through its basic domain, since HIV Tat has recently been reported to bind to this receptor in endothelial cells ...
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Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells
... and Flk-1/KDR [24]. While the ligands for Tie-1 and Tie-2 have not yet been identified, Flk-1 and Flt-1 are receptors for VEGF [1,2], an endothelial cell-specific mitogen whose ...
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Original Article Flk-1 Sca-1 mesenchymal stem cells: functional characteristics in vitro and regenerative capacity in vivo
... Despite tremendous advances in the manage- ment of ED in the past decade [25], DM- associated ED remains difficult to treat. To overcome this obstacle, one of the proposed therapeutic strategies is stem cell therapy, ...
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Wiegand, Ulrich (2009): Antiangiogenetische Therapie des humanen Pankreaskarzinoms durch ZD6474, ein neuartiger Inhibitor des vaskulären endothelialen Wachstumsfaktorrezeptor VEGF-R2 (KDR/FLK-1) Tyrosinkinase, nach orthotoper Implantation in die Nacktmaus. Dissertation, LMU München: Medizinische Fakultät
... Um das Wachstum von humanen Pankreaskarzinomen zu induzieren, wurde die humane Pankreaskarzinomzelllinie L3.6pl aus subkonfluenten Zellkulturflaschen herausgelöst. Den Kulturen wurde 4 ml einer Lösung mit 0,25%igem ...
88
Pro-angiogenic therapeutics for preeclampsia
... pro-angiogenic Flk-1. VEGF binding to Flt-1, on the other hand, is considered mildly anti-angiogenic [39]; this is because the angiogenic actions of Flt-1 are not as powerful as those of ...
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VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
... VEGF is mitogenic, angiogenic, and a potent mediator of vascular permeability. VEGF causes extravasation of plasma protein in skin bioassays and increases hydraulic conductivity in isolated perfused microvessels. Reduced ...
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Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor alpha in cultured human vascular endothelial cells
... In light of the foregoing observations, our finding that AP-1 and NFkB activities are not likely to mediate the regulatory ef- fects of TNF-a on KDR/flk-1 mRNA expression suggests that novel ...
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Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
... inhibitor treatment past the 9-hour time point. We also determined that treatment with NRP-1 inhibitor did not alter viral loads when compared to treatment with PBS using quantitative real time (RT)-PCR to detect ...
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Original Article Administration of LXW7 following transient cerebral ischemic stroke confers neuroprotection in rats
... as 1 h after ischemia, and its expression, together with that of some other integrins such as α5β1 and α2β1, contributes to various complex pathophysiological process- es that occur following cerebral stroke ...
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Hypoxia promotes differentiation of adipose-derived stem cells into endothelial cells through demethylation of ephrinB2
... Given that hASCs adopted a differentiation pathway to- wards the endothelial cell merely under hypoxia condition, we next evaluated at what degree did hypoxia affect EC differentiation by hASCs. As determined by ...
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Analysis of the VEGFr1 (Flt-1) isoforms in vascular development
... through flk-1 promotes the migration of endothelial cells by the regulation of focal adhesion kinase (FAK) and Src, which stimulate focal adhesion formation and turnover (Abedi and Zachary, 1995; Chou et ...
165
Vascular-targeted therapies for Duchenne muscular dystrophy
... The central paradigm behind the previously discussed PDE5 and ACEI therapies for DMD was that increasing the vasorelaxation capacity of the vasculature would be able to increase perfusion, diminish the effects from ...
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Hydrogen Sulfide Mitigates Cardiac Remodeling During Myocardial Infarction via Improvement of Angiogenesis
... VEGF, flk-1 and flt-1, endostatin, angiostatin and ...VEGF, flk-1 and flt-1 were significantly increased in treated mice while the level of endostatin, angiostatin and parstatin ...
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1 Benzylimidazolium hexafluorophosphate–1 benzylimidazole (1/1)
... structure, there are head-to-tail – stacking interactions between imidazole rings; the interplanar separation is 3.295 (1) A ˚ and the centroid–centroid separation is 3.448 (3) A ˚ . In the centrosymmetric anion, ...
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Propulsion in hexapod locomotion: how do desert ants traverse slopes?
... The employment of an alternating tripod gait to traverse uneven terrains is a common characteristic shared among many Hexapoda. Because this could be one specific cause for their ecological success, we examined the ...
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Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus.
... Virus was harvested from Step 2 clones and was used to infect fresh FLK cells, which were then placed under G418 selection in the presence of os-BLV antiserum Step 3 cells.. Alternativel[r] ...
6
Parsing Dependency Grammar using ALE
... coling02 dvi ????????? ??? ??????? ????? ???????????????????????? ??! ?"$# %?&('*),+ '/ 0)0'21?3 46587*9; <5>=(?@ A46?@B,C?DE9GFH9;IJ?@7?FLK?MNIJ7?O@D?IJP 9;IJQ8P6R6SUT VWT MN58DEX@587 Y KJI Z<[?5\R^][.] ...
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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
... preformed Flk-cadherin-catenin complex, which loosens EC-cell con- tacts and permits extravasation of serum and blood ...the Flk-cadherin-catenin complex and preserve endothelial barrier integrity, thereby ...
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