Foam cell formation
CXCL5 limits macrophage foam cell formation in atherosclerosis
... The ELR + -CXCL chemokines have been described typically as potent chemoattractants and activators of neutrophils during the acute phase of inflammation. Their role in atherosclerosis, a chronic inflammatory vascular ...
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Insulin and glucose play a role in foam cell formation and function
... the formation of oxidized LDL or foam cells, exacerbate the existing state of insulin ...on foam cell formation and cytokine produc- tion by ...that foam cell ...
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An In Vitro Coculture Model of Transmigrant Monocytes and Foam Cell Formation
... and foam cell formation in a matrix layer underneath a rabbit AEC ...well-executed cell trans- ...The cell exhibits abundant veillike projections (lamellipodia) (original magnification ...
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Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
... seen if bridging were the dominant mechanism. There- fore, the observation that the mean lesion area in the LPL +/– →C57BL/6 mice was not significantly different than in the LPL +/+ →C57BL/6 mice is of interest, as it ...
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Role of interleukin 1 beta in foam cell formation of THP 1 macrophages
... cholesterol, foam cell formation _____________________________________________________________________________________________ INTRODUCTION Macrophage-derived foam cells are the key cellular ...
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Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation
... ALDH2 SNP rs671, the inactive ALDH2*2 variant (E487K), affects around 40% of East Asians. This ALDH2 SNP has been associated with increased CVDs, such as heart failure and stroke (38), and gastrointestinal cancers (39). ...
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Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice
... form foam cells by ox-LDL in vitro. To explore whether MED affected foam cell formation, ...the foam cell forma- tion in a dose-dependent manner ...
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Differential inhibition of macrophage foam cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
... and foam-cell ...same cell type, exemplified by the macrophage foam-cell, each receptor also regulates dis- tinct programs of gene ...
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Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation
... the cell is via scavenger receptor-mediated uptake and inhibition of CD36 and SRA-1 scavenger receptor expression has been shown to limit foam cell formation ...of foam cell ...
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Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein
... inhibits foam cell formation and protects against atherosclerosis development ...macrophage foam cell, suggesting that ADRP may play an important role in autophagy ...
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Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis
... RAW264.7 cell line was established from the ascites of a tumour that was induced in a male mouse by the intraperitoneal injection of Abselon Leukaemia Virus (ATCC Number: ...of foam cell ...
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Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways
... plaque formation and to decrease the expression of MCP1, ICAM-1, and VCAM-1 in the aortic tissue in an LDL − / − mice model ...THP1-derived foam cell formation and ...
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Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis
... macrophage foam cells upon oxLDL or acLDL stimulation ...macrophage foam cell formation probably due to Ppar- g / d ...macrophage foam cell formation, thereby in fl uencing ...
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Original Article Sodium paeonolsilate inhibits ox-LDL induced macrophage foam cell formation and inflammation in atherosclerosis
... China. * Equal contributors. Received July 24, 2015; Accepted December 6, 2015; Epub February 15, 2016; Published February 29, 2016 Abstract: Atherosclerosis, formerly considered as a bland arterial collection of ...
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Apo A I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
... Therefore, it is likely that HDL particles exert their antiatherogenic effects in this model by blocking 1 or more steps leading to foam cell formation. Pathological studies have demonstrated the ...
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Biological Characteristics of Foam Cell Formation in Smooth Muscle Cells Derived from Bone Marrow Stem Cells
... the cell differentiation of smooth muscle lineage among ...These cell types are involved in the development of vascular systems, including an- giogenic sprouting and vessel ...of foam cell ...
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Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36
... became foam cells based on morphological (Oil Red O staining) and biochemical (5 times increase in cellular triglyceride) ...and foam cell ...
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Original Article Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARγ-ABCA1 pathway
... cess via upregulating the cholesterol transport- er ABCA1 and transcriptional activator PPARγ expression. This effect of quercetin results in decreased foam cell formation to alleviate ath- ...
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Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity
... 12,18–20 , which may be due to a lack of consistency with the models used and end points measured. Notably, the majority of these mechanistic studies are performed exclusively on young mice, primary cells from young mice ...
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Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation
... and foam cell ...the cell sur- face/in the cell membrane in some parts within the shoul- der regions of atherosclerotic lesions of ApoE −/− mice, indicating possible inflammatory processes in ...
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