focal adhesion kinase 1
Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1
... competition binding approaches to assess inhibitor selectivity/potency have identified crizotinib as a potent inhibitor of FAK1 ([22] and HMS Library of Integrated Network-based Cellular Signatures PF02341066 KINOMEscan ...
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The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
... through the cell membrane, thereby inhibiting the prolif- eration and spread of cancer cells [117]. Therefore, the research on FAK inhibitors is very promising. The phar- macodynamic activities of FAK inhibitors that ...
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A role for focal adhesion kinase in vascular smooth muscle cell proliferation, migration and differentiation
... We previously reported that overexpression of GFP-FRNK in cultured aortic SMCs by adenoviral gene transfer resulted in a modest increase in FRNK protein effectively inducing an exogenous FRNK to endogenous FAK ratio of ...
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Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)
... mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal ...examined focal adhesion protein homologs in ...
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Focal adhesion kinase overexpression and its impact on human osteosarcoma
... tyrosine kinase inhibitor, which is used to treat patients with chronic myelogenous leukemia (CML) [70–71] or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) ...
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The incredible ULKs
... the focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP200) both as an Ulk1-interacting protein and as an essential factor for the initial steps of autop- hagosome generation ...
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Focal adhesion kinase is not required for integrin function or viability in Drosophila
... While Fak56 protein appears to be ubiquitously expressed (Fox et al., 1999; Fujimoto et al., 1999; Palmer et al., 1999), phospho-Fak56 is strongly localized at muscle attachment sites. This implies that Fak56 is not only ...
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Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis
... We also found that FAK inhibitors reduced synovial fibro- blast migration, but that FAK protein itself did not appear to be required. This is surprising because FAK is required for migration in other cell types, such as ...
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Studies on Focal Adhesion Kinase in Human Breast Cancer Tissue
... Our present study involves 37 breast cancer female pa- tients. They were referred to Chittaranjan National Can- cer Institute, India because of clinical breast lump, suspi- cious mammographic finding or a breast symptom ...
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Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells
... tyrosine kinase receptor expressed by endo- thelial cells ...extracellular-signal-regulated kinase (Erk) pathway, focal adhesion kinase (FAK), c-Src family and paxillin [9, ...
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Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
... cell adhesion and migration into the RA synovial tissue (ST) may ameliorate ...ST. Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (Pyk)2 are two members of a family of ...
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Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk
... dependent on the axons from larval photoreceptor cells (Steller et al., 1987). However, our data demonstrate that SG cells in Drosophila form the optic stalk independently of R axons. First, SG cells proliferate before R ...
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Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol
... The method was used to determine the fluorescence when solution 5 (VB-48 PI-AO; ChemoMetec, Allerod, Denmark) was added to label thiol groups. Human skin fibroblasts were incubated for 24 hours with different ...
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Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells
... SCs were grown on FN-coated plates and then fixed with 4% PFA for 15 min, followed by permeabilization with 0.1% Triton-X-100 in PBS for 10 min. After the cells were blocked with 1% BSA plus 10% normal serum for ...
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The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
... FAK: focal adhesion kinase; FAP: fibroblast activation protein; FSP1: fibroblast specific protein 1; GAL3: galectin 3; HA: hyaluronan; HGF: hepatocyte growth factor; HR: hazard ratio; hStCs: ...
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Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
... FAK, focal adhesion kinase; GM-CSF, granulocyte macrophage-colony stimulating factor; IL, interleukin; IFN, interferon; JAK, Janus kinase; STAT, signal transducer and activator of ...
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Requirement of focal adhesion kinase in branching tubulogenesis
... The method to determine the fibronectin matrix assembly [16] was modified. To detect the amount of assembled fibronectin in cells cultured on dish, MDCK cells were cul- tured in the culture medium for 24 hrs then rinsed ...
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Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi’s Sarcoma Cells
... Kaposi’s sarcoma (KS) spindle cell growth and spread have been reported to be modulated by various cytokines as well as the human immunodeficiency virus (HIV) gene product Tat. Recently, HIV-1 Tat has been shown ...
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Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone
... Immunohistochemistry was performed as previously described [12]. Surgical specimens were initially decalci- fied for two weeks in an EDTA-containing buffer and embedded in paraffin. The endogenous peroxidase activ- ity ...
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Integrins and their ligands in rheumatoid arthritis
... are increased in the synovial lining layer [5]. Lymphocytes have been shown to attach to other synovial cells by binding to the fi bronectin coating on their cell surface by α4β1 and α5β1 and to some extent by ανβ3 ...
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