focal cerebral ischemia
Bone marrow stromal cells can promote the neurogenesis in subventricular zone in the rat with focal cerebral ischemia
... Methods: The rats were induced to permanent focal cerebral ischemia models with middle cerebral artery occlusion (MCA0). Test groups consisted of three groups: MCAO alone, intravenous infusion ...
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Focal cerebral ischemia in the TNFalpha-transgenic rat
... The suture-occlusion model of focal cerebral ischemia is feasible in the TNFα-Tg rat and produces a larger mean volume of infarction than in non-Tg littermates. We spec- ulate that the greater ...
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Original Article Activation of STAT3 is involved in neuronal apoptosis in focal cerebral ischemia/reperfusion rats via Bcl 2/Fas pathway
... sient focal cerebral ischemia [9, ...in focal cerebral ischemia/reperfusion rats remains ...in focal cerebral ischemia ...
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Expression of MICU1 after experimental focal cerebral ischemia in adult rats
... middle cerebral artery occlusion (MCAO) to create the standard focal cerebral ischemia ...of cerebral infarcts using triphenyltetrazolium chloride staining, as well as Western blot, ...
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CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia
... myocardial ischemia/reperfusion injury, multiple sclerosis, and experimental autoimmune en- cephalomyelitis ...after focal cerebral ischemia ...to focal cerebral ...
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VEGF induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
... that focal cerebral ischemia itself induces neuroproliferation in SVZ and SGZ ...of ischemia itself in the ischemic ...following ischemia, even the delayed effects of VEGF must have ...
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Original Article Bumetanide protects focal cerebral ischemia-reperfusion injury in rat
... The major findings of the present study are as follows. Firstly, bumetanide reduces brain edema after focal cerebral ischemia. Secondly, Figure 4. Bumetanide down-regulates the NKCC1 protein ...
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The assessment of behavioural deficits following focal cerebral ischemia
... of focal cerebral ischemia and the neural basis to covert attention and motivation in the ...middle cerebral artery, proving to be an adaptable technique across different strains of rat and ...
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receptor antagonist, on chronic brain injury after focal cerebral ischemia in rats
... The rats were anaesthetized with an intraperi- toneal injection of chloral hydrate (400 mg/kg). Transient focal cerebral ischemia was induced by a modified method of MCAO per a previously reported ...
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Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
... For cerebral transient focal ischemic induction, MCA was blocked by MCAO, as follows: The rats anesthetized by 4% isoflurane were placed in supine position and their shaved neck area was cleaned and ...
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The role of rutin in focal cerebral ischemia: oxidative stress factors and rotarod test
... during cerebral ischemia and reperfusion, which plays a major role in the pathophysiology of ischemic stroke or cerebral ischemia-reperfusion related injury (15, ...ischemic cerebral ...
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Neuroprotective effects of curdione against focal cerebral ischemia reperfusion injury in rats
... Materials and methods: Adult male Sprague Dawley rats were subjected to middle cerebral artery occlusion (MCAO) surgery for 2 h, followed by reperfusion stage. All animals received treatment once a day for 7 days ...
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Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats
... Notes: (A) representative magnetic resonance scans of rat brains from the bovine serum albumin-treated control group and the hsp70-treated experimental groups treated with protein concentrations of 0.5, 1.0, 2.5, and 5.0 ...
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Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice
... of ischemia the animals were re-anaesthetized and the filament was removed to permit ...and ischemia, body temperature was controlled by a temperature feedback controlled heating plate and maintained ...
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Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation
... during focal cerebral ischemia was able to maintain penumbral interstitial pO 2 close to the pre-ischemic values, whereas NBO delivery during reperfusion still doubled penumbral pO 2 that was ...
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Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats
... after focal cerebral ischemia, the most common cause of stroke, develops from a series of patho- logical processes, including excitotoxicity, inflammation, and ...in ischemia via NMDA ...
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Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury
... middle cerebral artery. The middle cerebral artery was loosely encircled with an 8-O suture for later occlu- ...A focal cerebral ischemia was induced by occlu- sion of the right common ...
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Rro/antioxidant activity of a new pir-10 substance (pyrimidine derivative) under experimentally simulated focal cerebral iscemia in rats
... after ischemia had been simulated and fur- ther on during 3 days. Focal cerebral ischemia was simulated by left-side occlusion of the mesencephalic artery (via its ...exploration. ...
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Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice
... experimental focal cerebral ischemia, and in FP-TBI within 96 hours, iNOS-derived NO is acutely detrimental (28), possibly because of toxic effects of NO metabolites such as ...after cerebral ...
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Original Article Up-regulated phospho-STAT3 in ischemia reperfusion rat model and oxygen and glucose deprivation cell model
... the ischemia stroke, ischemia-reperfusion inju- ry of neurons is a complex pathophysiological process ...a focal cerebral ischemia reperfusion rat model and an OGD cell model to mimic ...
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