Folate Metabolism
SPINA BIFIDA, FOLATE METABOLISM, AND DIETARY FOLATE INTAKE IN A NORTHERN CANADIAN ABORIGINAL POPULATION
... periconceptional folate. In studies of al- terations in folate metabolism and neural tube defects, only 10-20% of affected mothers and cases have shown definitive evidence of ab- normalities, such as ...
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Quantification of folate metabolism using transient metabolic flux analysis
... All metabolic flux analysis methodologies, including our tMFA implementation, are limited to the biochemical pathways build in into the calculations. To quantify con- tributions not accounted by the model, we made a bal- ...
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Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics
... that folate metabolism could be involved with the formation of ...the folate enzyme gene fau seems to reduce the incidence of persisters to ...antibiotics. Folate impaired bacteria had a lower ...
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Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population
... in folate metabolism through affecting global DNA methylation, which is essential for embryonic development and the for- mation of the cardiovascular system [22], it has attracted the most attention as an ...
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Computational Modelling Folate Metabolism and DNA Methylation: Implications for Understanding Health and Ageing
... intracellular folate metabolism was developed in the 1970s and had a strong pharmacological theme ...the folate cycle, was developed by Nijhout et ...the folate cycle, model simulations were ...
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In silico experimentation with a model of hepatic mitochondrial folate metabolism
... poses many challenges. Measuring concentrations and especially reaction velocities is not easy in living cells, and these measurements become particularly difficult when substrates and some reactions are sequestered into ...
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Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study
... tested differences between two groups by Student t test, and the differences between more than two groups were estimated by ANOVA. p values \ 0.05 were considered significant. We used ANOVA post hoc Bonferroni test for ...
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Original Article Relationship of folate metabolism related enzymes MTHFR and MTRR gene polymorphisms with unexplained recurrent spontaneous abortion
... cell folate and plasma folate levels lower than control group (P < ...serum folate and red cell folate, homocysteine homocysteine levels does not exist significant difference (P > ...
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PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case–control study in a population with relatively low folate intake
... plasma folate levels and/or elevated homocysteine (Hcy) levels are considered to be risk factors for ...low folate intake. Maternal plasma folate and Hcy levels were also measured, and the ...
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Evaluation of Folate Metabolism in patients with Idiopathic Non-cirrhotic Intra-hepatic Portal Hypertension.
... or folate cause elevation in serum homocysteine levels and most of the patients had been to various hospitals before coming to liver clinic and had been on vitamin ...
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Neuronal injury: folate to the rescue?
... of folate in the regeneration of afferent spinal neurons after ...in folate metabolism, from cellular entry to DNA methylation, the authors show that axonal regeneration relies upon the integrity of ...
5
Folate Content of Asian Vegetables
... found folate levels in spinach significantly declined by 47 % after 8 days of storage at 4 ...in folate of only 26 % after 7 days was reported (Chen et ...in folate concentration (Figure ...
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Prevalence of Neural Tube Defects, Folate Status, and Folate Fortification of Enriched Cereal-Grain Products in the United States
... with folate metabolism, other known risk fac- tors, and folate status of women with or without NTD- affected ...on folate status from women who have had NTD-affected pregnancies are correlated ...
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GNMT Expression Increases Hepatic Folate Contents and Folate-Dependent Methionine Synthase-Mediated Homocysteine Remethylation
... hepatic folate binding protein that binds to, and, subsequently, may be inhibited by ...cellular folate metabolism, in tumorigenesis and antifolate ther- apies, is not understood ...growth, ...
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Neuronal injury: folate to the rescue?
... bon metabolism has detrimental effects for proper CNS ...for folate supplementation in the treatment and prevention of neurodegenerative and neuropsychiatric disorders remains to be estab- ...of ...
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Iron and Folate Contents of Tajik Legumes
... In our study, legumes were soaked overnight for 16 h. Soaking legumes for some period of time is one of the common practices of Tajik households. Soaking im- proves iron absorption, which degrades the phytate [20]. ...
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Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine
... detect folate receptor expression in tissue samples and cell lines of head and neck squamous carcinoma, including 20 tissue samples of nasopharyngeal carcinoma, 16 tissue samples of laryngeal carcinoma, and HNE-1, ...
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MUTANTS OF PARAMECIUM DEFECTIVE IN CHEMOKINESIS TO FOLATE
... These double mutants were crossed to other fol- mutants with normal body morphology and scored in the F1 for body and behavior for complementation of the two fol- [r] ...
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Kinetics of the Normal Folate Enterohepatic Cycle
... in folate homeostasis. Three isotopes of folate were employed in a rat model to study several parameters: (a) intestinal transport; (b) variation in hepatic uptake after different routes of administration; ...
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The mechanism of folate transport in rabbit reticulocytes
... Folate transport in phenylhydrazine-induced rabbit reticulocytes was studied with the non- metabolized folate-analog, methotrexate. The time-course of methotrexate uptake into a mixed population of ...
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