Folate Receptors
Effect of perturbation of specific folate receptors during in vitro erythropoiesis
... of folate receptors in normal human ...placental folate receptor serum and preimmune serum to determine the role of such a receptor in erythroid ...intracellular folate deficiency with a 70% ...
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Functional coating of liposomes using a folate–polymer conjugate to target folate receptors
... Abstract: Folate-polymer-coated liposomes were developed for targeted chemotherapy using doxorubicin (DXR) as a model ...drug. Folate-poly(L-lysine) (F–PLL) conjugates with a folate modification ...
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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
... A number of presentations covered various aspects of the physiology and pathophysiology of FR and facilitative transporters. Professor Satyajit Mayor (National Centre for Biological Sciences, Bangalore, India) opened ...
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Expression of folate receptors alpha and beta in normal and cancerous gynecologic tissues: correlation of expression of the beta isoform with macrophage markers
... that folate receptor beta may indeed be a marker of this cell ...Since folate receptor alpha is expressed exclusively by the epithelial cells themselves in these tumors, we can now link the expression of ...
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Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors
... at folate receptors (FRs) for precise delivery of therapeutic cargo to the nuclei of FR-positive cells and to evaluate its potential, particularly for delivery of therapeutic agents (eg, the Auger electron ...
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Translational upregulation of folate receptors is mediated by homocysteine via RNA heterogeneous nuclear ribonucleoprotein E1 interactions
... cellular folate concentration is ...during folate deficiency is sufficient to trigger the inter- action of the trans-factor/hnRNP-E1 with the 18-base cis-element within the 5′-UTR of FR mRNA to result in ...
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Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review
... capture folate from outside the cell; FR-bound folate is then transported intracellularly by FR-mediated endocy- tosis, by engulfing it within a vesicle called the ...
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Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine
... detect folate receptor expression in tissue samples and cell lines of head and neck squamous carcinoma, including 20 tissue samples of nasopharyngeal carcinoma, 16 tissue samples of laryngeal carcinoma, and HNE-1, ...
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Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies
... for folate receptors. Folate-PEG-PEI has been demonstrated to be a potentially safe and efficient gene vector, particularly for folate receptor-positive cell gene ...that ...
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Lack of Association between Folate Receptor Autoantibodies and Neural Tube Defects
... cow’s-milk folate receptors and human placental folate receptors and from stored and fresh samples and show that sample degrada- tion during storage was ...that folate intake was higher ...
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Multifunctional Biocompatible Fluorescent Carboxymethyl Cellulose Nanoparticles
... of folate conjugated Carboxymethyl cellulose with QDs and the cytotoxicity of drug-loaded folate conjugated Carboxymethyl cellulose was studied with MCF7 and L929 cell lines by Alamar blue ...of ...
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Release of Ca2+ from the Endoplasmic Reticulum Contributes to Ca2+ Signaling in Dictyostelium discoideum
... bradykinin receptors of fibroblasts are improperly folded in the absence of calreticulin, so that Ca 2⫹ responses to bradykinin are dramatically reduced in calreticulin-deficient cells (18, ...and folate ...
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SYNTHESIS AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES (MSN) LOADED COX II INHIBITOR – MELOXICAM FOR TARGETED COLORECTAL CANCER TREATMENT
... Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles MSN were used as folate marker and polyethyleneimine was used t[r] ...
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Cryptophane Derivatives as Gas Sensors and Hyperpolarized Xenon-129 Biosensors
... For cancer detection by hyperpolarized 129 Xe MRI, a new folate-conjugated cryptophane biosensor was developed that targets folate receptors (FR) overexpressed in a majority of cancer cells. The ...
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Determining bioavailability of food folates in a controlled intervention study
... predetermined folate con- tent, allowed several potential confounding effects to be over- come, including poor subject compliance and displacement of the usual dietary folate intake with intervention foods ...
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Cancer chemotherapy: targeting folic acid synthesis
... in folate metabolism, namely DHFR, β -glycinamide ribonucleotide transformylase (GARFT), 5 ′ -amino-4 ′ -imidazolecarboxamide ribonucleotide transformylase (AICARFT), and thymidylate synthetase ...
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Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation
... between folate intake and placental weight; our data did not show significantly elevated pla- cental weight in treatment groups compared to placebo groups ...therefore folate supplementation may have no ...
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Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-<em>O</em>-carboxymethylated chitosan–folic acid micelles
... To deeply understand the mechanism of micelle endocytosis via MCF-7 cells, the cellular uptake study was conducted at different conditions; MCF-7 cells were incubated with rhodamine B-loaded micelles in the presence or ...
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Cassinelli, Valentina (2017): Click chemistry as powerful bioconjugation tool applied to DNA nanotechnology and cytogenetic analysis. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 37 cytoplasm the disulphide linker is hydrolyzed and the siRNA is free to trigger RNA interference. Triantennary GalNac-siRNAs are other conjugates composed by siRNA connected with three ligand moieties by mean of a ...
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Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation
... of folate to the surface of the ...with folate, maintained sustained release, and a faster release of CM was more visibly observed than the unconjugated ...
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