forkhead box
Forkhead box transcription factor FOXO3a suppresses estrogen dependent breast cancer cell proliferation and tumorigenesis
... GST-forkhead box class O (FOXO)3a (GST-FO [amino acids 1 to 300] and GST-FO [amino acids 301 to 673]) fusion proteins as indicated and GST alone (negative control), and analyzed by SDS-PAGE and immunob- ...
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Forkhead Box Transcription Factor Regulation and Lipid Accumulation by Hepatitis C Virus
... forkhead box transcription factors play a role in modulating ex- pression of lipid droplets. For this, Huh7.5 cells were infected with HCV 2a and transfected after 1 day with siRNA for specific inhi- bition ...
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Forkhead box K2 inhibits the proliferation, migration, and invasion of human glioma cells and predicts a favorable prognosis
... Purpose: Forkhead box K2 (FOXK2) is a member of the forkhead box family of transcription factors. Recently, researchers discovered that overexpression of FOXK2 inhibits the proliferation and ...
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Immune Reconstitution and Recovery of FOXP3 (Forkhead Box P3)-Expressing T Cells After Transplantation for IPEX (Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked) Syndrome
... Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a rare X-linked disorder that usually presents in early childhood with immune enteropathy, diabetes mellitus, and other autoimmune ...
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20 hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting
... Insulin inhibits transcription factor Forkhead box O (FoxO) activity, and the steroid hormone 20-hydroxyecdysone (20E) activates FoxO; however, the mechanism is unclear. We hypothesized that 20E upregulates ...
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MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
... Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyper- glycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show that MAPK phosphatase–3 ...
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Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer
... Abstract: Previous studies have demonstrated the cancer-type specific role of forkhead box protein A1 (FOXA1) in human malignancies. However, the clinical significance of FOXA1 and its biological function ...
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Original Article MicroRNA-223 inhibits hepatic gluconeogenesis by targeting forkhead box O1
... found Forkhead Box O1 (FOXO1) was a target of miR-223 and the subsequent functional analysis of FOXO1 verified the regulatory ef- fect of miR-223 on ...
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Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression
... Forkhead box C1 (FOXC1) is a member of the forkhead family of transcription factors that are characterized by a DNA-binding forkhead ...
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Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation
... identified forkhead box a1 (Foxa1) as a key transcriptional component that interacts with AR on multiple prostatic enhancers and controls androgen- induced activation of both human and rodent ...
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Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
... DCM: diabetic cardiomyopathy; FOXO: forkhead box (other) transcriptional factor; PTM: posttranslational modifications; NFκB: nuclear factor κB; PEPCK: phosphoenolpyruvate carboxykinase[r] ...
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Analysis of Forkhead Box Protein 3 (Foxp3) in Allergic Rhinitis Patients
... Background: A new concept in understanding allergic diseases is regulatory T cells (Tregs), which control the immune reaction caused by Th2 cytokine production. Forkhead Box Protein 3 (FoxP3) is a marker ...
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Update of human and mouse forkhead box (FOX) gene families
... The forkhead box (FOX) proteins are transcription factors that play complex and important roles in processes from development and organogenesis to regulation of metabolism and the immune ...the ...
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miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1
... FOXO1 which is a member of the forkhead transcrip- tional factor family, functions as a tumor suppressor in various carcinomas. For example, breast, prostate, cervi- cal, gastric and endometrial cancer, its ...
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Genetic variants in Forkhead box O1 associated with predisposition to sepsis in a Chinese Han population
... First, ten sepsis patients and eight normal controls were selected for the initial screening of SNPs or indel sites using whole-exome sequencing, and sepsis-related SNPs and indel sites [r] ...
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Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR
... Transwell assays revealed that EGFR upregulation rescued the decreased migration and invasion abilities induced by FOXK2 knockdown, while EGFR downregulation significantly suppressed[r] ...
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Genome-wide identification of long noncoding RNAs and their competing endogenous RNA networks involved in the odontogenic differentiation of human dental pulp stem cells
... Methods: hDPSCs were induced to differentiate into odontoblasts in vitro, and the expression profiles of lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) in differentiated and undifferentiated cells were obtained ...
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Leucine rich alpha 2 glycoprotein promotes Th17 differentiation and collagen induced arthritis in mice through enhancement of TGF β Smad2 signaling in naïve helper T cells
... Abbreviations CIA: Collagen induced arthritis; DMEM: Dulbecco’s modified Eagle’s medium; ELISA: Enzyme-linked immunosorbent assay; Foxp3: Forkhead box p3; GAPDH: Glyceraldehyde-3-phospha[r] ...
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Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?
... CCR = CC-family chemokine receptor; DARC = Duffy antigen receptor for chemokines; EAE = experimental allergic encephalomyelitis; Foxp3 = forkhead box p3; IFN = interferon; IL = interleuk[r] ...
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CD163+ M2c like macrophages predominate in renal biopsies from patients with lupus nephritis
... The number of forkhead box protein P3 FoxP3 + regulatory T cells was analyzed in International Society of Nephrology/Renal Pathology Society ISN/RPS lupus classes and correlation tested [r] ...
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