Formyl peptide receptor 1
Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
... Increased formyl peptide receptors and RAGE expression in glial cells in an APP/PS1 transgenic mouse model In a first set of experiments we investigated the expres- sion and localisation of the mouse ...
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Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion
... built with 37 EOC tissue samples. IHC highlighted vari- able expression of FPR1 both in the cytoplasm and on the plasma membrane of tumor cells (Fig. 7). FPR1 ex- pression levels were evaluated by assessing either the ...
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Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells
... with receptor activation and subsequent cell migration [22, 31, 32]; ìì) uPAR binds to FPR1 through its Ser 88 -Arg-Ser-Arg-Tyr 92 sequence, thus promoting FPR1 internalization which is essential for cell ...
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Exocytosis of Neutrophil Formyl Peptide Receptor-Like 1 (fPRL1) Results in Downregulation of Cytoplasmic fPRL1 in Patients with Purulent Dermatitis
... The upregulation of fPRL1 on neutrophil membranes, regarded as the activation of neutrophils, is induced by preincubation with bacterial LPS and/or cytokines but is hardly induced without this priming condition ...
7
The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA
... N-formyl peptide receptors (FPRs) are a family of G-protein-coupled receptors that were initially identified in phagocytic leukocytes, however subsequent reports have demonstrated FPRs to be expressed in ...
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LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells
... the formyl peptide receptor-like 1 (FPRL1) [28], purinergic receptor P2X7 (P2X7) [29], and epidermal growth factor receptor (EGFR) ...
11
Interleukin-18 Primes the Oxidative Burst of Neutrophils in Response to Formyl-Peptides: Role of Cytochrome b558 Translocation and N-Formyl Peptide Receptor Endocytosis
... observed with granulocyte colony-stimulating factor and IL-1, which also have modest priming effects on the PMN oxidative burst in response to fMLP (10, 28). However, we found here that some of the mechanisms ...
11
Characterization of the murine n-formyl peptide chemotactic receptor
... concentrations of IL-3 the cells continue to grow but do not react to the presence of other growth factors such as G-CSF and GM-CSF. This suggests that IL-3 modulates the receptors for other growth factors. Therefore ...
260
Cyclic Nucleotide induced Maturation of Human Promyelocytic Leukemia Cells
... morphologically. Formyl-peptide receptor expression was the earliest marker of these modified programs of ...The receptor appeared within 2 h after treatment and increased linearly for 72 ...
13
The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
... Coronary brain sections (10 μ m) from rats were cut on a cryostat, collected on Superfrost Slides (Merck, Braunschweig, Germany), air dried for 24 h and stored at − 80°C. For immunofluorescence staining, sections were ...
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An angiogenic role for the human peptide antibiotic LL 37/hCAP 18
... active peptide and is referred to as ...The peptide is induced by inflammatory or infectious stimuli and displays direct antimicrobial activity by interaction with the cell membranes of microorganisms ...
9
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
... The intestinal epithelium forms a selective barrier that separates luminal contents from underlying tissue compartments, thereby playing a pivotal role in regulating exposure of the mucosal immune system to luminal ...
13
Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
... When compared with nondiabetic controls, T2D patients have a several-fold increased risk of developing cardiovascu- lar disease (CVD) [1]. At least, 68% of people >65 years of age with diabetes die of some form ...
11
Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist
... This peptide effect was accompanied by an increase in the plasma levels of the anti-inflammatory cytokine IL-10 in LPS-treated ...the peptide derived from fibroblast growth factor receptor ...
18
Past and current perspective on new therapeutic targets for Type-II diabetes
... Alarming increase in the incidence of diabetes demands for successful therapies. American biopharmaceutical research organizations are engaged in the development of about 180 new medicines for diabetes and related ...
17
TRPA1 and other TRP channels in migraine
... neuropathic pain. Mechanical hyperalgesia [52] and ongoing neuronal discharge [53,54] evoked by complete Freund’s adjuvant (CFA) and tumour necrosis factor-α (TNFα), and mechanical hyperalgesia induced by low doses of ...
8
Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... Natural insulin (Lilly, Indianapolis, IN, USA), four insulin analogs (insulin aspart [Novo Nordisk, Bagsværd, Denmark], insulin lispro [Lilly, Indianapolis, IN, USA], insulin detemir [Novo Nordisk, Bagsværd, Denmark], ...
11
Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients
... Total RNA was isolated from the harvested synovial tissue using TRIzol reagent (Invitrogen, Carlsbad, CA) following the manufacturer’s protocol. The extracted RNA was used as template for first-strand cDNA synthe- sis of ...
7
Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... functional receptor for GLP-1 [34]. However this receptor could be different from the cAMP-linked GLP-1r expressed in the pancreas, but its existence implies that a direct skeletal action of ...
24
Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... activation of the GLP-1R and then the cAMP-dependent PKA pathway. Activation of the PKA pathway is widely recognized as a key intracellular signaling mechanism in ischemic and pharmacological preconditioning. Subse- ...
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