Fosfomycin-resistance
The N Acetylmuramic Acid 6 Phosphate Phosphatase MupP Completes the Pseudomonas Peptidoglycan Recycling Pathway Leading to Intrinsic Fosfomycin Resistance
... intrinsic fosfomycin resistance (Fig. 1). We used fosfomycin sensitivity testing in combination with multigenome homology analyses for the identification of mupP of ...Since fosfomycin ...
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<p>Identification of <em>fosA10</em>, a Novel Plasmid-Mediated Fosfomycin Resistance Gene of <em>Klebsiella pneumoniae</em> Origin, in <em>Escherichia coli</em></p>
... Results: A novel fosA gene with signi fi cant homology (>98%) with fosA6 and fosA5 genes was identi fi ed by WGS and was named fosA10. FosA10 shared 56.1% to 98.6% amino acid sequence identity with other reported ...
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Frequency of colistin and fosfomycin resistance in carbapenem-resistant Enterobacteriaceae from a tertiary care hospital in Karachi
... 12.3% fosfomycin resistance among CREs. Both colistin and fosfomycin are salvage antibiotics for treating MDR and XDR ...emerging resistance against these agents significantly reduces ...
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Widespread Fosfomycin Resistance in Gram Negative Bacteria Attributable to the Chromosomal fosA Gene
... fomycin resistance in Gram-negative bacteria by conjugation of glutathione to the anti- ...in fosfomycin-resistant Escherichia coli ...high-level fosfomycin resis- tance when expressed in ...
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Molecular Monitoring of Fosfomycin Resistance in Escherichia coli Strains Isolated from Patients with Urinary Catheters in north-east of Iran
... of resistance to fosfomycin in Escherichia coli isolates originated from patients hospitalized with urinary tract infection in the intensive care unit (ICU) and coronary care unit ...to fosfomycin ...
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Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study
... in fosfomycin treatment episodes over the course of the study ...as fosfomycin resistant in cases of relapse following ...prolonged fosfomycin. Among all urinary isolates collected over a year, ...
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The susceptibility to fosfomycin of Gram-negative bacteria isolates from urinary tract infection in the Czech Republic: data from a unicentric study
... showed fosfomycin trometamol as a prom- ising antibiotic for urinary tract infection in our ...of fosfomycin worldwide has led to increased levels of resistance in ...of fosfomycin ...
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Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli
... Fosfomycin resistance due to defective UhpT or GlpT is reported to confer high fitness cost, and strains with such resistance are known to be outcompeted by strains that are susceptible to ...
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Activity of Fosfomycin in Extended Spectrum Beta Lactamases Producing Klebsiella pneumonae from Hospital Acquired Urinary Tract Infections
... is; fosfomycin which is available as oral and IV ...of fosfomycin for treatment of UTIs has been increased due to increased rate of resistance to other agents, good safety, resistance of ...
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Fosfomycin Susceptibility in Carbapenem Resistant Enterobacteriaceae from Germany
... the fosfomycin inhibition zone are due to resistance-conferring mu- tations and the location of colonies within the inhibition zone is mainly determined by chance, this reading guide would lead to ...
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A Retrospective Study of Extended Spectrum Beta- Lactamases (ESBL) Urinary Tract Infections Treated with Fosfomycin and in vitro Susceptibility of 102 Isolates to Fosfomycin
... low, fosfomycin resistance has been documented in the literature ...a fosfomycin-modifying enzyme (FosA) has been found in Pseudomonas aeruginosa ...the fosfomycin resistant uropathogens have ...
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The Role of fosA in Challenges with Fosfomycin Susceptibility Testing of Multispecies Klebsiella pneumoniae Carbapenemase Producing Clinical Isolates
... impacts fosfomycin activity and limits convenient diffusion-based susceptibility ...of fosfomycin resistance, such as trans- porter mutations or MurA ...with fosfomycin against fosA-positive ...
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<p>Synergistic Effects from Combination of Cryptotanshinone and Fosfomycin Against Fosfomycin-Susceptible and Fosfomycin-Resistant <em>Staphylococcus aureus</em></p>
... chromosomal resistance gene MurA, GlpT and UhpT, there are four mutations in 7 strains of fosfomycin- resistant strains, namely G790A mutation on MurA, C299T mutation and G248 deletion on GlpT, and G1044T ...
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THE INTERACTION OF MECILLINAM AND FOSFOMYCIN INTO MULTI DRUG RESISTANT ESCHERICHIA COLI FROM URINE PATIENTS
... Urinary Tract Infection is one of the most common diseases that is very difficult to cure because of the presence of multi-Drug resistant pathogens. The cure is usually to prescribed antibiotics, however, there is a gap ...
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A study on combination of daptomycin with selected antimicrobial agents: in vitro synergistic effect of MIC value of 1 mg/L against MRSA strains
... The development of optimal therapeutic strategies for serious MRSA infections remains of great interest be- cause glycopeptide monotherapy has multiple disadvan- tages, including varied tissue penetration, slow bacterial ...
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Case Report Treatment for severe infections due to carbapenem-resistant Klebsiella pneumoniae in pediatric patients: combination of fosfomycin with carbapenems
... was 14.69 ng/mL, and the percentage of neu- trophils was 90.4%. Slight elevation was noted in the value of transaminase and total bilirubin. Mild abnormality was found in the function of coagulation. Subsequently, ...
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Extensively drug-resistant Acinetobacter baumannii in a Thai hospital: a molecular epidemiologic analysis and identification of bactericidal Polymyxin B-based combinations
... In our study, we also observed that antimicrobial monotherapies had little or no bactericidal activity, with the exception of PB which retained bactericidal activity in the majority of the isolates. However, when PB ...
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<p>Pharmacodynamics Of Linezolid-Plus-Fosfomycin Against Vancomycin-Susceptible And -Resistant Enterococci In Vitro And In Vivo Of A <em>Galleria mellonella</em> Larval Infection Model</p>
... and fosfomycin were calculated according to the doses administered in the human ...(ii) fosfomycin alone (200 mg/kg), (iii) linezolid (10 mg/kg) and fosfomycin (200 mg/kg) in combination, (iv) ...
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In vitro antibacterial effect of fosfomycin combination therapy against colistin-resistant <em>Klebsiella pneumoniae</em>
... Conjoint analysis of PK/PD could help to maximize treatment efficacy, decrease adverse effects, and minimize resistance rate, especially for the optimized use of antimicro- bial agents with different routes of ...
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Fosfomycin Suppresses Chemokine Induction in Airway Epithelial Cells Infected with Respiratory Syncytial Virus
... Respiratory syncytial virus (RSV) infects airway epithelial cells, causing bronchiolitis and pneumonia. Inflammation is mediated by various cytokines secreted from RSV-infected airway epithelial cells, and it promotes ...
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