Frontotemporal Dementia
Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease
... Frontotemporal dementia (FTD, OMIM: 600274) is a neurodegenerative disease characterized by abnormalities in personality, behaviour and language with relative early preservation of episodic memory ...
7
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
... This research was funded by National Institute on Aging grants (K23AG055688; to R.M.T.), (K23AG045289; to D.C.P.), (K08AG052648; to S.S.), (K24AG053435; to L.T.G.), (P01 AG019724; to W.W.S), (U01 AG052943; to M.GT.), ...
18
Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia
... Genetic Frontotemporal dementia Initiative (GENFI) consortium revealed hippocampal atrophy in presymptomatic MAPT from 15 years before estimated symptom onset [10], and as this medial temporal structure is ...
12
Impaired self-other differentiation in frontotemporal dementia due to the C9ORF72 expansion
... van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, ...
6
Alteration of white matter MR signal intensity in frontotemporal dementia
... In terms of signal acquisition technique, sev- eral possibilities exist for improving the modest sensitivity of frontotemporal signal changes in detecting frontotemporal dementia. Motion arti- facts ...
12
Cardiovascular risk factors and frontotemporal dementia: a case–control study
... of frontotemporal dementia are the tauopathies, and thyroid hormone level abnormalities in frontotemporal dementia were found to be frequent (38%) in a previous study ...
6
Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes
... Progress has been made in understanding the genetics and molecular biology of frontotemporal dementia (FTD). Targets for intervention have been identified, therapies are being developed, and clinical trials ...
9
The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer’s disease
... variant frontotemporal dementia (bvFTD) and Alzheimer ’ s disease (AD), with degeneration of the anterior cingulate region increasingly recognized as a strong predictor of ...
6
Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini review
... Frontotemporal lobar degeneration (FTLD) represents a group of clinically, neuropathologically and genetically heterogeneous disorders with plenty of overlaps between the neurodegenerative mechanism and the ...
9
Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging
... Recent findings have led to a renewed interest and support for an active role of inflammation in neurodegenerative dementias and related neurologic disorders. Detection of neuroinflammation in vivo throughout the course ...
7
Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review
... “frontotemporal dementia and slowly progressive,” “fron- totemporal dementia and phenocopy,” “frontotemporal dementia and non-progressive,” “frontotemporal dementia and ...
15
Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia
... Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the degradation of misfolded and redundant proteins through the ubiquitin-proteasome system and macroautophagy. UBQLN2 received much ...
11
Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions
... Frontotemporal dementia (FTD) is characterised by early behavioural change and progressive erosion of social cog- nition associated with frontotemporal lobar degeneration ...
10
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
... Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder, which has three cardinal features: behavioral and personality changes, ...
9
Frontotemporal dementia and amyotrophic lateral sclerosis proteins in neurite health and dysfunction
... A number of proteins have been identified which are pathologically and/or genetically associated with both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). A hexanucleotide repeat ...
219
Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy
... Loss of insight is one of the core features of frontal/behavioural variant frontotemporal dementia (FTD). FTD shares many clinical and pathological features with corticobasal degeneration (CBD) and ...
12
Dyslexia susceptibility genes influence brain atrophy in frontotemporal dementia
... of frontotemporal dementia; DHPLC 5 denaturing high performance liquid chromatography; DSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders, 4th edition; FOV 5 field of view; FTD 5 ...
9
Late life bipolar disorder evolving into frontotemporal dementia mimic
... Objectives: Although bipolar disorder has been understood classically as a cyclic disease with full recovery between mood episodes, in the last decade, evidence has accumulated supporting progressive features. The ...
6
Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia
... It has been challenging to identify clinical cognitive markers that can differentiate patients with AD from those with behavioral variant frontotemporal dementia (bvFTD). There is considerable overlap in ...
18
Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia
... Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral ...
7