Frontotemporal dementia (FTD)
Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
... Frontotemporal dementia (FTD) is a heterogeneous disease encompassing behavioral variant FTD (bvFTD) and the primary progressive aphasias (PPAs): the semantic variant (svPPA), the nonfluent ...
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Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
... Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative conditions affecting the frontal and temporal lobes and, to a varying degree, the subcortical grey ...document, FTD ...
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Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort
... In this study, we respectively identified two novel muta- tions c.1959_1960insGT, p.E653fs and c.2063_2064delTT, p.L688Rfs*14 in a sporadic case with FTD-ALS and in an ALS-FTD family (Fig.1a and b). These ...
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CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia
... Most work so far in synaptic biomarkers has focused on cerebrospinal fluid (CSF) where increased protein concentrations are thought to reflect degeneration of functional synapses [2]. In Alzheimer’s disease (AD), the ...
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Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
... total FTD groups and in each clinical subgroup are shown in table ...total FTD group vs controls (mean ...tinguishing FTD from controls, a cutoff of 33 pg/mL gave a sensitivity of 84% and specificity ...
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CSF and blood biomarkers in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis
... factor; FTD: Frontotemporal dementia; GFAP: Glial fibrillary acidic protein; LMN: Lower motor neuron; MCP-1: Monocyte chemoattractant protein-1; MND: Motor neuron disease; PGRN: Progranulin; ...
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Frontotemporal lobar degeneration: current perspectives
... atypical frontotemporal lobar degeneration with ubiquitinated inclusions; AGD, argyrophilic grain disease; ALS, amyotrophic lateral sclerosis; BiBD, basophilic inclusion body disease; bvFTD, behavioral-variant ...
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Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
... familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor Neurone Disease ...with Frontotemporal dementia (FTD), 6 with FTD + MND and 7 with MND alone (all 21 patients ...
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Trigeminal neuralgia due to pontine infarction
... the frontotemporal lobar degenerations (FTLDs), progressive supranuclear palsy (PSP), and corticobasal degeneration ...variant frontotemporal dementia (FTD), 13 as progressive non-fluent ...
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Applied multimodal diagnostics in a case of presenile dementia
... presenile dementia are dementia with Lewy bodies (DLB), frontotemporal dementia with memory impairment (FTD) and chronic traumatic encephalopathy ...variant frontotemporal ...
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Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study
... with dementia and the ...with dementia and carers. Dementia diagno- ses were obtained from medical records of the partici- pants and classified in seven groups: Alzheimer’s disease (AD), vascular ...
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FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases
... (FTD): Frontotemporal dementia; (FTLD-TDP): Frontotemporal lobar degeneration with ubiquitin and TDP-43 positive neuronal inclusions; (FTLD- MND): Frontotemporal lobar degeneration ...
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Frontotemporal Dementias: A Review
... loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to describe the spectrum of non-Alzheimers dementias characterized by focal atrophy of the frontal and anterior ...
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Prevalence of cerebrospinal fluid Alzheimer disease like pattern in atypical dementias
... between Frontotemporal Dementia (FTD), Corticobasal Syndrome (CBS), Progressive Supranuclear Pal- sy Syndrome (PSP), FTD with motor neuron di- sease (FTD-MND) is often challenging, ...
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The role of progranulin in diabetes and kidney disease
... 3-kinase; FTD: frontotemporal dementia; TNFR: tumor necrosis factor receptor; TNFα: tumor necrosis factor-α; BMI: body mass index; MCP-1: monocyte chemoattractant protein-1; CRP: C-reactive protein; ...
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Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
... frontotemporal dementia (FTD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) [18–23]. TREM2 is a type 1 transmembrane protein, and its ectodomain is shed at the plasma membrane by ...
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Cognitive and behavioral features of c9FTD/ALS
... Familial frontotemporal dementia (FTD) with or without parkinsonism has been associated with mutations in genes encoding microtubule-asso ciated protein tau (MAPT), progranulin (PGRN), and less ...
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Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
... for frontotemporal dementia (FTD), other disorders of movement and cognition, and early ...for dementia, Parkinson disease and related disorders, MND, adult neurology, medicine for the ...
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Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies
... We conducted systematic literature searches of the asso- ciation between neurodegeneration and TBI in the Med- ical Literature Analysis and Retrieval System Online (MEDLINE®)/PubMed (US National Library of Medicine, ...
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Cardiovascular medication burden in dementia disorders: a nationwide study of 19,743 dementia patients in the Swedish Dementia Registry
... different dementia disorders. Methods: We obtained information about dementia patients from the Swedish Dementia ...these dementia disorders: Alzheimer ’ s disease (n = 8,139), mixed ...
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